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FGF3 — IGF1
Text-mined interactions from Literome
Cao et al., Zhonghua Yan Ke Za Zhi 1997
:
( 1 ) EGF,
b-FGF ,
IGF-I significantly
increased the DNA 6.6-12.2 times in human RPE cells in comparison with the control, the rank order of potency of the factors being EGF > b-FGF > IGF-I
Rosenthal et al., Mol Endocrinol 1991
:
Concomitantly,
FGF resulted in a 60-70 % increase in
IGF-I binding compared to that in control myoblasts ... Scatchard analyses and studies of gene expression demonstrated that the increased
IGF-I binding
induced by
FGF reflected parallel increases in IGF-I receptor content and mRNA abundance
Kalluri et al., Eur J Neurosci 2007
:
However,
FGF-2 ( ERK activator ) in the
presence of
IGF-I ( Akt activator ) increased the proliferation of cells
Jeschke et al., Gene Ther 2007
:
IGF-I , KGF and their combination cDNA treatment significantly ( P < 0.05 ) accelerated re-epithelization,
increased IGF-I, KGF,
FGF , VEGF and collagen type IV expression, while it had no effect on collagen type I and III expression
Fazeli et al., J Clin Endocrinol Metab 2010
:
In a transgenic mouse model,
FGF-21 reduces
IGF-I levels by inhibiting signal transducer and activator of transcription-5, a mediator of the intracellular effects of GH
Naville et al., Mol Cell Endocrinol 1990
:
Human chorionic gonadotropin ( hCG ) and basic
fibroblast growth factor (FGF) stimulate in a dose dependent manner
IGF-I production by Leydig cells ... The secretion of
IGF-I by Sertoli cells was
stimulated by FSH and
FGF
Kralisch et al., J Endocrinol 2013
(Insulin Resistance) :
Notably,
FGF21 significantly
inhibited IGF1 secretion into HepG2 cell culture supernatants in preliminary in vitro experiments
Penhoat et al., J Biol Chem 1989
:
The basal secretion of
IGF-I ( 6 +/- 1 ng/48 h/10 ( 6 ) cells ) was
stimulated 3-, 4.5-, and 9.5-fold by
fibroblast growth factor , angiotensin II ( A-II ), and ACTH, respectively, but not by growth hormone
Wilkie et al., Growth Regul 1995
:
This study describes the
effect of acidic and basic
fibroblast growth factor (FGF) on DNA synthesis in chick satellite cells in vitro and interactions with
insulin-like growth factor-I (IGF-I) and exogenous heparin
Ververis et al., Circ Res 1993
:
PDGF and
FGF but not Ang II
regulate vascular
IGF I receptors through a PKC dependent pathway
Scheinowitz et al., Int J Cardiol 1997
(Disease Models, Animal...) :
IGF has been found to promote physiological forms of cardiac hypertrophy, and
FGF induces neovascularization