◀ Back to IGF1

IGF1 — IL6

Text-mined interactions from Literome

Tu et al., Pediatr Res 1999 : IGF-I increases interferon-gamma and IL-6 mRNA expression and protein production in neonatal mononuclear cells ... IGF-I alone induced a high level of IL-6 mRNA expression and protein production in neonatal MNC ... IGF-I significantly increased mRNA expression and protein production of both IL-6 and interferon-y but had no influence on that of IL-2 and IL-4 in PHA stimulated neonatal MNC
Tu et al., Cancer Res 2000 (MAP Kinase Signaling System...) : IGF-I also successfully activated PI 3-K in four of four MM patient specimens, and IL-6 activated PI 3-K in three of four specimens ... In correlation with activation of PI 3-K, IGF-I also effectively activated the AKT kinase in 8226 and OCI-My5 cells, and IL-6 activated AKT in AF-10 and MH.60 cells
Vermes et al., J Bone Joint Surg Am 2001 (Osteolysis) : Exogenous tumor necrosis factor-alpha also enhanced the release of interleukin-6 ( p < 0.01 ) and transforming growth factor-beta1 ( p < 0.05 ), whereas the secretion of transforming growth factor-beta1 was increased by insulin-like growth factor-I and prostaglandin E2 as well
Ben et al., Zhonghua Shao Shang Za Zhi 2001 : Additionally, rhGH ( at 40 ng/ml ) and IGF-1 ( at all tested concentrations ) could activate the secretion of TNF and IL-6 from cultured mice Mphi in vitro
Anwar et al., Circulation 2002 (Arteriosclerosis) : IL-1beta, IL-6 , and IFN-gamma did not regulate IGF-1 , IGF-1 receptor (R), or IGF binding proteins ( IGFBPs ) ... IL-1beta, IL-6 , and IFN-gamma did not regulate IGF-1, IGF-1 receptor (R), or IGF binding proteins ( IGFBPs )
De Benedetti et al., Horm Res 2002 (Growth Disorders) : However, IL-6 does not directly affect IGF-I production both in vitro and in vivo
Barbieri et al., Am J Physiol Endocrinol Metab 2003 (Chronic Disease...) : In vitro studies demonstrated that IL-6 inhibits the secretion of insulin-like growth factor I (IGF-I) and its biological activity, suggesting that the negative effect of IL-6 on muscle function might be mediated through IGF-I
Perrier d'Hauterive et al., Journal de gynécologie, obstétrique et biologie de la reproduction 2004 : The molecular basis of the implantation window remains to be defined In the present study, we investigated the role of hCG, TGFbeta1, IGF1 and IGF2 in the secretion of leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) by human epithelial endometrial cells in culture
Gao et al., Zhonghua Shao Shang Za Zhi 2004 (Burns) : The plasma levels of PGE2, TXB2, TNF-alpha and IL-6 significantly decreased and insulin, rhGH and IGF-1 obviously increased when compared with those in group B
de Jong et al., Scand J Gastroenterol 2004 (Colorectal Neoplasms...) : PH is associated with a lower acute-phase and total IGF-I response and a higher HGF and IL-6 response compared with laparotomy
Méndez-Dávila et al., J Endocrinol Invest 2004 (Osteoporosis) : We investigated the effects of 17betaestradiol and two selective estrogen receptor modulators, tamoxifen and raloxifene, on the expression and release of constitutive and interleukin-1 stimulated interleukin (IL)-6, transforming growth factor-beta1 ( TGF-beta1 ) and insulin-like growth factor-1 by osteoblasts in primary culture from trabecular bone of healthy post-menopausal women
Sawczenko et al., Proc Natl Acad Sci U S A 2005 (Colitis...) : We hypothesized that IL-6 , induced by intestinal inflammation, suppresses growth and inhibits IGF-I expression
Nemet et al., Am J Physiol Regul Integr Comp Physiol 2006 : The results suggest that IL-6 plays a role in the GH -- > IGF-I response to intense exercise
Ahmad et al., J Pediatr Endocrinol 2007 (Birth Weight) : Growth in preterm infants is characterized by increases in IGF-I and GHBP with simultaneous decreases in IL-6 and IL-1ra
Kooijman et al., Growth Horm IGF Res 2007 (Inflammation...) : Since serum IGF-I levels are related to risks of prostate cancer and cytokines like interleukin (IL)-6 and IL-8 have been implicated in prostate cancer progression, we investigated the effects of IGF-I on IL-6 and IL-8 expression in the prostate cancer cell
Iwasaki et al., J Dent Res 2008 (MAP Kinase Signaling System) : We conclude that IL-6/sIL-6R increases ascorbic-acid induced alkaline phosphatase activity through IGF-I production, implying that IL-6 acts not only as an osteolytic factor, but also as a mediator of osteoblastic differentiation in periodontal ligament cells
Rojas et al., Oncogene 2011 (Cell Transformation, Neoplastic...) : Moreover, we find that paracrine IL-6 stimulates the autocrine IL-6 loop and autocrine activation of insulin-like type I growth factor receptor ( IGF-IR ) to confer the tumorigenic property and also that activation of signal transducer and activator of transcription 3 ( STAT3 ) is critical in these processes ... Inhibition of STAT3 activation suppresses IL-6 induced upregulation of IGF-IR and its ligands, namely IGF-I and IGF-II
Al-Shanti et al., J Cell Biochem 2012 : Inhibitory effects of IL-6 on IGF-1 activity in skeletal myoblasts could be mediated by the activation of SOCS-3
Lazarus et al., Lymphokine Cytokine Res 1993 : Insulin-like growth factor-1 activity is inhibited by interleukin-1 alpha, tumor necrosis factor-alpha, and interleukin-6
Nishiyama et al., Biochem Biophys Res Commun 1993 : When cells were incubated with IL-6 in the presence or absence of IGF-I , cell proliferation was not observed
Thissen et al., Endocrinology 1997 : To determine whether cytokines can directly inhibit the production of IGF-I by the liver, we investigated the regulation of IGF-I gene expression by interleukin (IL)-1 beta, IL-6 , and tumor necrosis factor (TNF)-alpha ( 10 ng/ml ) in a model of rat primary cultured hepatocytes ... Moreover, IL-1 beta abolished the IL-6 induced IGF-I mRNA response ... In contrast, IL-6 did not impair the IGF-I mRNA response to GH
Jelinek et al., J Immunol 1997 (Multiple Myeloma) : The specificity of the IGF response was confirmed using an IGF-I receptor Ab, and additional studies demonstrated that IGF responsiveness did not result from induction of autocrine IL-6 expression
Franchimont et al., Endocrinology 1997 : Interleukin-6 with its soluble receptor enhances the expression of insulin-like growth factor-I in osteoblasts ... We tested the effects of IL-6 and its soluble receptor (IL-6sR) on the expression of insulin-like growth factor (IGF)-I and IGF-II in cultured osteoblast enriched cells from fetal rat calvariae ( Ob cells ) ... IL-6 did not modify IGF-I messenger RNA ( mRNA ) levels, but when tested in the presence of IL-6sR, IL-6 at 1 to 100 ng/ml increased IGF-I transcripts by up to 3.2-fold after 24 h. IL-6sR caused a small increase in IGF-I mRNA levels when tested alone ... IL-6 and IL-6sR increased immunoreactive IGF-I levels by 2.4-fold after 24 h and 6.4-fold after 48 h. Cycloheximide prevented, and indomethacin markedly decreased, the effect of IL-6 and IL-6sR on IGF-I mRNA levels, but hydroxyurea did not ... In conclusion, IL-6 , in the presence of IL-6sR, increases IGF-I synthesis in Ob cells ; this effect may lead to a secondary increase in bone formation
Glazebrook et al., J Vasc Res 1998 : Regulation of insulin-like growth factor-1 expression in vascular endothelial cells by the inflammatory cytokine interleukin-1