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IGF1 — LGALS1
Text-mined interactions from Literome
Bhaumick et al., J Clin Endocrinol Metab 1992
:
The augmented stimulatory effect of EGF on
hPL secretion by all cells in the
presence of
IGF-I was decreased ( P less than 0.05 ) when expressed per number of human chorionic gonadotropin ( BhCG ) -positive cells ... The dose-response curves of hPL stimulation by IGF-I in the presence of EGF revealed that the decreased
effect of
IGF-I on
hPL secretion by BhCG-positive staining cells was due to the difference in magnitude ( approximately 1.5 times ) of stimulation of BhCG staining of and hPL secretion by the cells
Briese et al., Zentralbl Gynakol 1989
(Fetal Growth Retardation) :
The
IGF-synthesis is
dependent on the
human placental lactogen (HPL) , i.e. IGF-II is mainly responsible for fetal development the estimation of the production of IGFs by the fetus supports investigations about fetal somatomedins to clear fetal growth retardations and diabetic macrosomia respectively
Nakago et al., Nihon Naibunpi Gakkai Zasshi 1995
:
To elucidate the
effects of growth hormone (GH), prolactin (PRL), and
human placental lactogen (hPL) on the regulation of
insulin-like growth factor ( IGF-1 ), we compared plasma IGF-1 levels, the pattern of circulating IGF-1-IGF binding protein complexes ( IGF-1 complexes ), and unsaturated binding protein ( USBP ) levels among 1 ) naturally growing Wistar rats at several developmental stages, 2 ) rats subcutaneously administered GH, and 3 ) hypophysectomized rats treated with each of the three hormones
Maruo et al., Early Pregnancy 1995
:
By contrast, in 6-12-week placentae,
IGF-I and IGF-I receptor were localized in both cytotrophoblasts and syncytiotrophoblasts and IGF-I
stimulated the secretion of hCG and
hPL following the enhancement of the proliferative activity of trophoblasts