Gene interactions and pathways from curated databases and text-mining

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IGF1 — REN

Text-mined interactions from Literome

Marsh et al., J Physiol 2001 : Insulin-like growth factor I alters renal function and stimulates renin secretion in late gestation fetal sheep
Liu et al., Arch Physiol Biochem 2003 : Effects of insulin and insulin-like growth factor-I on renin gene expression in the renal cortical cells of ovine fetuses ... In order to determine whether there are direct effects of IGFI or insulin on renin gene expression in the kidneys of ovine fetuses, we treated the renal cortical cells of ovine fetuses with IGFI or insulin ... It is possible that IGFI and insulin stimulate renin mRNA expression by increasing cAMP concentration in the cells
Jaffa et al., Diabetes 1997 (Diabetes Mellitus, Experimental) : These data suggest that 1 ) diabetes suppresses kallikrein and renin gene expression, and these abnormalities are reversed by insulin or IGF-I ; and 2 ) the diabetic state produces resistance to IGF-I induction of kallikrein and renin gene expression