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IGF1 — REN
Text-mined interactions from Literome
Marsh et al., J Physiol 2001
:
Insulin-like growth factor I alters renal function and
stimulates renin secretion in late gestation fetal sheep
Liu et al., Arch Physiol Biochem 2003
:
Effects of insulin and
insulin-like growth factor-I on
renin gene expression in the renal cortical cells of ovine fetuses ... In order to determine whether there are direct
effects of
IGFI or insulin on
renin gene expression in the kidneys of ovine fetuses, we treated the renal cortical cells of ovine fetuses with IGFI or insulin ... It is possible that
IGFI and insulin
stimulate renin mRNA expression by increasing cAMP concentration in the cells
Jaffa et al., Diabetes 1997
(Diabetes Mellitus, Experimental) :
These data suggest that 1 ) diabetes suppresses kallikrein and renin gene expression, and these abnormalities are reversed by insulin or IGF-I ; and 2 ) the diabetic state produces resistance to
IGF-I induction of kallikrein and
renin gene expression