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IL8 — MMP2

Text-mined interactions from Literome

Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Huang et al., Am J Pathol 2002 (Melanoma...) : IL-8 blockade by ABX-IL8 significantly inhibited the promoter activity and the collagenase activity of matrix metalloproteinase-2 in human melanoma cells, resulting in decreased invasion through reconstituted basement membrane in vitro
Watanabe et al., Oral Oncol 2002 (Carcinoma, Squamous Cell...) : Second, we thus also investigated the effect of IL-8 on MMP release in OSCC cells
Mian et al., Clin Cancer Res 2003 (Carcinoma, Transitional Cell...) : IL-8 blockade by ABX-IL8 significantly inhibited the expression, activity, and transcription of MMP-2 and MMP-9, resulting in decreased invasion through reconstituted basement membrane in vitro
Sun et al., Connect Tissue Res 2003 (Arthritis, Rheumatoid) : Furthermore, the induction of the MMP expression and activities by interleukin-1 was suppressed by the oscillatory shear
Mulayim et al., Fertil Steril 2004 : To evaluate the effect of interleukin-8 (IL-8) on endometrial stromal cell metalloproteinase ( MMP ) activity and invasiveness ... IL-8 increases MMP activity and invasive capability of endometrial stromal cells in culture ; IL-8 may be involved in the pathogenesis of endometriosis and menstrual physiology
So et al., Gynecol Oncol 2004 (Neoplasm Invasiveness...) : IL-8 did not affect cellular migration, MMP2 activation, or uPA expression
Li et al., Angiogenesis 2005 : Autocrine role of interleukin-8 in induction of endothelial cell proliferation, survival, migration and MMP-2 production and angiogenesis
Thirumangalakudi et al., J Alzheimers Dis 2007 : Gelatin zymography demonstrated IL-8 induced MMP-2 and MMP-9 activity
Hanrahan et al., J Clin Oncol 2010 (Lung Neoplasms) : For example, increases in IL-8 with VCP, MMP-9 with CP, and VEGF with vandetanib monotherapy were associated with increased progression risk, and increase in intercellular adhesion molecule 1 with vandetanib was associated with decreased risk
Jovanović et al., Reproduction 2010 : Exogenous IL8/CXCL8 increased trophoblast cell migration and invasion, which may be partly attributable to stimulation of MMP2 and MMP9 levels and an increase in integrins
De Oliveira et al., Placenta 2010 : IL-8 increased levels of secreted MMP-2 , but did not alter any of the other proteases or protease inhibitors tested
Tanabe et al., Molecules (Basel, Switzerland) 2011 : This concentration of AC-PACs also significantly increased the secretion of IL-8 ( 6-fold ) and inhibited the secretion of both MMP-2 and MMP-9
Hoffmann et al., Biochem Pharmacol 2011 (Adenocarcinoma...) : Proinflammatory IL-6 and PGHS-2 as well as proangiogenic IL-8 and VEGF were induced by IL-1, whereas the secretion of invasion promoting MMP-2 remained unaffected
Thirkettle et al., J Biol Chem 2013 (Breast Neoplasms) : In particular, MMP-8 proteolytically activates IL-8 and, thereby, regulates neutrophil chemotaxis in vivo
Salamonsen et al., Hum Reprod 1996 : Progesterone withdrawal from stromal cell cultures ( for the final 4 days of a 10 day culture ) increased the release of all four enzymes : all but MMP-2 were also stimulated by interleukin-1 or tumour necrosis factor alpha added to short-term stromal cultures
Luca et al., Am J Pathol 1997 (Lung Neoplasms...) : Moreover, when the MMP-2 promoter was linked upstream of the chloramphenicol acetyltransferase (CAT) reporter gene, CAT activity was up-regulated in IL-8 but not in control transfected cells, suggesting that IL-8 is involved in MMP-2 gene transcription
Bar-Eli et al., Pathobiology 1999 (Disease Progression...) : Activation of MMP-2 by IL-8 can enhance the invasion of host stroma by the tumor cells and increase angiogenesis and, hence, metastasis