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Takeuchi et al., Cytokine 1999
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However, IL-1alphaenhanced the ability of megakaryocytes to produce IL-8 and growth regulating oncogene-alpha ( GRO-alpha ) in the presence of TPO Ashizawa et al., Acta Endocrinol (Copenh) 1989
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Both interleukin 1 alpha and beta inhibited TSH induced thyroid peroxidase mRNA in a dose responsive manner ; 10 ( 3 ) U/1 interleukin 1 caused maximal suppression of TSH induced thyroid peroxidase mRNA level to nearly basal levels ... These results demonstrate that interleukin 1 directly inhibits TSH induced thyroid peroxidase gene expression and provide further evidence for a paracrine role of interleukin 1 as a local inhibitor of thyroid hormone synthesis
Higuchi et al., Br J Haematol 1997
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These results suggest that TPO stimulates not only the proliferation and differentiation of the progenitors capable of megakaryocytic lineage expression but also IL-8 release by the megakaryocytic cells with the aid of IL-1