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CDC73 — MAPK3

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Weng et al., Eur J Pharmacol 2000 : Platelet activating factor (PAF) , tumor necrosis factor-alpha (TNF-alpha), and insulin-like growth factor-1 (IGF-1) had little effect on MAPK activation
Ciesla et al., Shock 2000 (MAP Kinase Signaling System) : Platelet activating factor (PAF) has been implicated as a key inflammatory mediator in postinjury neutrophil priming and requires p38 MAPK signaling to produce its biologic effects ... Receptor dependent ( fMLP ), N-formyl-methionyl-leucyl-phenylalanine, fMLP ) and receptor independent ( PMA ) O2- production was measured by reduction of cytochrome c in resting and PAF primed PMNs. Total p38 MAPK protein PAF mediated p38 MAPK activation was assessed by western blot of PMN lysates ... Clinically relevant levels of HTS alone did not activate p38 MAPK but inhibited PAF mediated p38 MAPK activation
Bernatchez et al., Br J Pharmacol 2001 : 3. Moreover, we demonstrate that VEGF mediated PAF synthesis requires the activation of p38 MAPK , likely by directing the conversion of lyso-PAF to PAF
Wang et al., Oncogene 2003 (Carcinoma...) : PAF activated three prominent mitogen activated protein kinase modules ( ERK, p38MAPK and Jun N-terminal kinases ) in these cells, inhibited proliferation and induced differentiation ( measured by the induction of Waf1/p21 and the induction of the differentiation related marker CEA )
Owen et al., Biochim Biophys Acta 2005 : These data are consistent with a model in which stress induced PAF accumulation is regulated positively by p38 MAPK and negatively by ERK-1/2 ... These data are consistent with a model in which stress induced PAF accumulation is regulated positively by p38 MAPK and negatively by ERK-1/2
Wu et al., Biochem J 2006 : The PAF induced MAPK ( mitogen activated protein kinase ) activation and IL-8 ( interleukin 8 ) release in HT-29 cells, and chemotaxis in leucocytes were abolished by alk-SMase treatment
Si et al., Am J Physiol Gastrointest Liver Physiol 2008 (Adenocarcinoma...) : PAF significantly increased the phosphorylation of ERK1/2 MAPK , cPLA(2), and STAT5
Tobe et al., Cell division 2009 : It was found that Swe1 mediated inhibitory tyrosine phosphorylation of Cdc28 during filamentous growth is in part mediated by Ras2 activation of PKA, but not Kss1-MAPK , signaling
Franklin et al., J Immunol 1993 : Taken together, the results suggest that PAF stimulation of B cells induces the tyrosine phosphorylation and activation of microtubule associated protein-2 kinase
Ferby et al., J Biol Chem 1994 : Stimulation of guinea pig neutrophils with platelet activating factor (PAF) caused a rapid and transient activation of mitogen activated protein kinase ( MAPK ) ... Wortmannin, an inhibitor of phosphatidylinositol 3-kinase, partially ( approximately 50 % ) inhibited PAF induced MAPK activation
Bonaccorsi et al., Biochim Biophys Acta 1997 (Adenocarcinoma) : In particular, we studied the effect of PAF on protein tyrosine phosphorylation and mitogen activated protein kinase ( MAPK ) activity, as well as the effect of protein tyrosine kinase ( PTK ) and protein kinase C ( PKC ) inhibition on PAF induced increase of c-fos gene expression and thymidine incorporation in HEC-1A cells ... We also found that PAF increased tyrosine phosphorylation and activity of p42 MAPK , suggesting the involvement of this important intermediary enzyme in the proliferative effect of PAF
Nick et al., J Clin Invest 1997 : Neither FMLP nor PAF activated c-jun NH2-terminal MAPk ( JNKs )
Ferby et al., Adv Exp Med Biol 1996 : PAF induced MAPK activation is inhibited by wortmannin in neutrophils and macrophages ... In the present study we examined the mechanism by which PAF activates MAPK in native cells such as guinea-pig neutrophils and P388D1 macrophage-like cells ... Using molecular biological methods we are presently examining whether hetrodimeric ( p85/p110 ) type PI 3-kinase is the actual target of wortmannin involved in PAF mediated activation of MAPK