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FGF8 — MAPK3

Pathways - manually collected, often from reviews:

• Reactome Reaction: FGF8 → MAPK3 (reaction) Lax et al., Mol Cell 2002, Wu et al., Biol Chem 2003, Gotoh et al., Cancer Sci 2008, Zhou et al., Cell Res 2009

Text-mined interactions from Literome

Viñals et al., Mol Cell Biol 1999 : p42/p44 MAPK activation by fetal calf serum or fibroblast growth factor was restrained in confluent cells in comparison with the activity found in sparse cells
Klingenberg et al., J Biol Chem 1999 : The results indicate that while the mutations strongly affect the ability of the growth factor to bind to heparin, they do not affect much the binding to the specific FGF receptors, activation of mitogen activated protein kinase or transport of the growth factor to the nucleus
Fabbro et al., Pharmacol Ther 1999 : CGP 41251 inhibits reversibly intracellular PKC activity, induction of c-fos and the corresponding activation of the mitogen activated protein kinase induced by either tumor promoting phorbol esters, platelet derived growth factor, or basic fibroblast growth factor , but not by the epidermal growth factor
O'Reilly et al., Mol Cell Biol 2000 : Previously, using a dominant negative mutant approach, we showed that the protein-tyrosine phosphatase SHP-2 is necessary for FGF induced MAPK activation , mesoderm induction, and elongation of animal caps
Wu et al., J Biol Chem 2000 : MAPK/ERK kinase inhibition diminished VEGF-, FGF- , and EGF promoted thymidine incorporation into DNA
Wang et al., Oncogene 2000 (Bone Neoplasms...) : Specific inhibition of FGF induced MAPK activation by the receptor-like protein tyrosine phosphatase LAR ... We found that although both EGF and FGF induce activation of mitogen activated protein kinase ( MAPK ), LAR only inhibits FGF induced MAPK activation ... The specific effect of LAR on FGF induced MAPK activation appeared to be mediated by specific inhibition of the phosphorylation of two signal transducers that act downstream of the FGF receptor, FRS2 and a 180 kDa protein, and by prevention of their interaction with the adaptor protein GRB2
Cohen et al., J Neurosci Res 2000 : Further, FGF-9 stimulated mitogen associated protein kinase ( MAPK ) phosphorylation
Curran et al., Dev Biol 2000 : Activation of MAPK in young embryos is abolished by injection of a dominant negative FGF receptor ( XFD ) RNA, suggesting that MAPK is activated primarily by FGF in this context ... Inhibition of FGF signaling does not block posterior neural gene expression ( HoxB9 ) or activation of MAPK ; however, inhibition of FGF signaling does cause a statistically significant decrease in the level of activated MAPK
Kamimura et al., J Biol Chem 2001 : We also show that FGF dependent mitogen activated protein kinase activation is significantly reduced in dHS6ST double stranded RNA injected embryos
Hadari et al., Proc Natl Acad Sci U S A 2001 : Experiments with FRS2 alpha-deficient fibroblasts demonstrate that FRS2 alpha plays a critical role in FGF induced mitogen activated protein ( MAP ) kinase stimulation, phosphatidylinositol-3 (PI-3) kinase activation, chemotactic response, and cell proliferation
Mehta et al., Oncogene 2001 (Prostatic Neoplasms) : In vitro expression of the transcription factors Elk-1 and MEF2A ( substrates for ERK1/2 and p38, respectively ) for functional quantification, confirmed the pattern of FGF induced MAPK activations in COS-7 cells
Fürthauer et al., Nat Cell Biol 2002 (MAP Kinase Signaling System) : Sef is a feedback induced antagonist of Ras/MAPK mediated FGF signalling ... Here we show that in zebrafish, Sef functions as a feedback induced antagonist of Ras/Raf/MEK/MAPK mediated FGF signalling
Maher et al., Oncogene 2002 (MAP Kinase Signaling System) : TPA treatment has little or no effect on FGF receptor activation but specifically inhibits the activation of p38 MAPK but not other downstream signaling pathways implicated in cell proliferation
Park et al., Mol Cell Biol 2002 : Moreover, FGF induced activation of mitogen activated protein ( MAP ) kinase is also inhibited by XLPTP1 morpholino antisense oligonucleotides ; however, introduction of RNA encoding XLPTP1 is able to rescue morphological and biochemical effects of antisense inhibition
Stevens et al., Mol Endocrinol 2003 : Fibroblast growth factor 2 (FGF2) stimulated MAPK in osteoblasts, and pretreatment with T3 for 6 h induced a more rapid response to FGF that was increased in magnitude by 2- to 3-fold
Jackson et al., Mol Endocrinol 2003 (MAP Kinase Signaling System...) : FGF induction of rPRL transcription is independent of Ras, but mediated by a protein kinase C-delta (PKCdelta) dependent activation of MAPK ( ERK )
Bansal et al., J Neurosci Res 2003 : Specific inhibitor of FGF receptor signaling : FGF-2 mediated effects on proliferation, differentiation, and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells
Lai et al., Oncogene 2004 (Carcinoma, Squamous Cell...) : Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of ERK/mitogen activated protein kinase ( MAPK ) signaling mediated by fibroblast growth factor ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF)
Mason et al., Mol Biol Cell 2004 : Sprouty2 efficiently inhibited FGF induced phosphorylation of extracellular signal regulated kinase 1/2 in c-Cbl-null fibroblasts, thus indicating that the FGF dependent binding of c-Cbl to Sprouty2 was dispensable for its inhibitory activity
Sun et al., Cancer Res 2004 (Lung Neoplasms...) : Furthermore, epidermal growth factor, platelet derived growth factor, and fibroblast growth factor dependent stimulation of Erk1/2 phosphorylation are not affected at concentrations as high as 10 microM
De Robertis et al., Annu Rev Cell Dev Biol 2004 : Neural induction by anti-BMPs such as Chordin requires mitogen activated protein kinase ( MAPK ) activation mediated by FGF and IGF
Ishibe et al., Clin Cancer Res 2005 (Sarcoma, Synovial) : FGF signals in synovial sarcoma induced the phosphorylation of extracellular signal regulated kinase ( ERK1/2 ) and p38MAPK but not c-Jun NH2-terminal kinase
Shimada et al., Clin Cancer Res 2005 (Mammary Neoplasms, Animal) : Neutralizing activity of KM1334 was confirmed by both blocking of FGF8b binding to its three receptors ( FGFR2IIIc, FGFR3IIIc, and FGFR4 ) and FGF8b induced phosphorylation of FGFR substrate 2alpha and extracellular signal regulated kinase 1/2 in SC-3 cells
Ishikawa et al., Oncogene 2005 (Multiple Myeloma...) : In KMS-11, IL-6 activated signal transducer and activator of transcription 3 ( STAT 3 ) while FGF activated extracellular signal regulated kinase 1/2 ( ERK 1/2 ) and phosphatidylinositol (PI)-3 kinase ... Furthermore, the FGF induced activation of ERK 1/2 contributed to the serine phosphorylation of STAT 3, suggesting that the signaling crosstalk between the cytokine receptor, IL-6 receptor alpha/gp 130 and the growth factor receptor tyrosine kinase, FGFR 3
Hoch et al., Development 2006 (Embryo Loss...) : However, the mutant receptor is able to drive Fgfr1 functions during gastrulation and somitogenesis, and drives normal MAPK responses to Fgf
Cuevas et al., J Cell Mol Med 2006 (Glioma) : Accordingly, it should be expected this new synthetic FGF inhibitor to affect the activation levels of MAPK
Easton et al., J Neurochem 2006 (Neuroblastoma) : In addition to Shc, fibroblast growth factor receptor substrate 2 (FRS2) is required for the BDNF induced activation of MAPK
Estes et al., Oncol Rep 2006 (Adrenal Cortex Neoplasms...) : However, this inhibition is independent of ERK1/2 activation as levels of FGF induced phospho-ERK 1/2 remain unchanged upon knockdown of either FGFR1 or FGFR3
Antoine et al., Biochem Biophys Res Commun 2006 : Interestingly, FGF2 , which is mitogenic on endothelial cells and hepatocytes stimulates a sustained MAPK activation in both cell types, while FGF18 causes a short transient activation of the MAPK pathway in endothelial cells but a sustained activation in hepatocytes
Smith et al., FEBS Lett 2006 (MAP Kinase Signaling System) : Negative feedback predominates over cross-regulation to control ERK MAPK activity in response to FGF signalling in embryos
Stavridis et al., Development 2007 : A discrete period of FGF induced Erk1/2 signalling is required for vertebrate neural specification
Lin et al., Am J Physiol Endocrinol Metab 2009 : FGF-8a induced the phosphorylation of p42/p44 mitogen activated protein kinase ( MAPK ) in osteoblastic cells ; however, its mitogenic actions were not blocked by either the MAPK kinase ( MEK ) inhibitor U-0126 or the PI 3-kinase (PI3K) inhibitor LY-294002
Eiselleova et al., Stem Cells 2009 : In addition, FGF-2 signaling via FGFR2 activated MAPK kinase/extracellular signal regulated kinase and AKT kinases, protected hESC from stress induced cell death, and increased hESC adhesion and cloning efficiency
Miyagawa et al., Development 2009 : Fgf8 induces phosphorylation of Erk1/2 and cell proliferation in the GT mesenchyme in vitro, yet Fgf4/8 compound-mutant phenotypes indicate dispensable functions of Fgf4/8 and the possibility of redundancy among multiple Fgfs in GT development
Canalejo et al., J Am Soc Nephrol 2010 (Disease Models, Animal...) : Furthermore, FGF23 induced phosphorylation of extracellular signal regulated kinase 1/2 , which mediates the action of FGF23
Zhu et al., Cell communication and signaling : CCS 2010 : We have previously shown in rat mammary fibroblasts that in cells deficient in sulfation, and so in HS co-receptor, FGF-2 can only stimulate a transient phosphorylation of p42/44 MAPK and so can not stimulate DNA synthesis
Dai et al., Clinical lymphoma, myeloma & leukemia 2011 (MAP Kinase Signaling System...) : Overexpression of MPS-1 resulted in decreased fibroblast growth factor ( FGF2 ) receptor 3 and impaired endogenous MAPK/ErK signaling
Yoo et al., Stem Cells 2011 (MAP Kinase Signaling System) : Under a chemically defined medium, FGF inhibition blocked phosphorylation of extracellular signal regulated kinase 1/2 ( ERK 1/2 ) with a significant reduction of PAX6 expressing neuroepithelia, indicating that FGF regulates neural induction through ERK1/2 activation
Hwangpo et al., J Biol Chem 2012 (MAP Kinase Signaling System) : Overexpression of GRIN potentiated FGF activation of MAPK and decreased tyrosine phosphorylation of Sprouty2 ... Decreased expression of GRIN both diminished FGF activation of MAPK and blocked CB1R attenuation of MAPK activation
Harding et al., Development 2012 : We demonstrate that activation of Fgf receptor ( Fgfr ) induces intracellular Ras-MAPK , which is required for apical constriction and rosette formation in the pLLp
Watt et al., Arthritis Rheum 2013 : In contrast, FGF signaling blockade with PD173074 reduced all MAPK and IKK activation by ~50 % and inhibited a different subset of genes but had no effect on Src-like signaling
Lorget et al., Am J Hum Genet 2012 (Achondroplasia...) : In ACH human growth-plate chondrocytes, we demonstrated a decrease in the phosphorylation of extracellular-signal regulated kinases 1 and 2, confirming that this CNP analog inhibits fibroblast-growth-factor mediated MAPK activation
Tang et al., Cell 1995 : In ectodermal explants, delta P blocks fibroblast growth factor ( FGF ) - and activin mediated induction of mesoderm and FGF induced mitogen activated protein ( MAP ) kinase activation
Chabre et al., Endocrinology 1995 : Indeed, ACTH completely blocks ( IC50 = 0.01 nM ) the stimulation of MAPK by AII, fibroblast growth factor-2 , or TPA
Hartley et al., Dev Biol 1994 : MAP kinase ( MAPK ) is activated in animal cap explants from Xenopus embryos in response to mesoderm induction by FGF ... However, activin can potentiate the activation of MAPK by FGF as early as 1 min after administration
Vouret-Craviari et al., Biochem J 1993 : We found that : ( i ) both thrombin and TMP rapidly activate p44mapk in a dose dependent manner with maximum activation at around 5 min, ( ii ) after the initial burst of activation, a second and long lasting wave of activation is observed in response to thrombin ( 10-100 nM ) but not to TMP ( up to 300 microM ), ( iii ) FGF alone ( 25 ng/ml ), like thrombin, rapidly and persistently activates p44mapk ( 20-fold at 5 min and about 3-fold after 2 h ), ( iv ) TMP added together with FGF strongly potentiates the second and sustained phase of p44mapk activation
Kornmann et al., J Clin Invest 1998 (Pancreatic Neoplasms) : EGF, FGF-2 , and IGF-I enhanced mitogen activated protein kinase activity in antisense expressing clones, but failed to stimulate their proliferation
Mehta et al., J Biol Chem 1998 : Incubation of the NR cells with either form of FGF-1 resulted in its binding to cell-surface FGF receptors, activation of mitogen activated protein ( MAP ) kinase , and induction of c-fos and c-myc
Padua et al., J Mol Cell Cardiol 1998 (Reperfusion Injury) : Finally, FGF-2 induced increased active MAPK at sarcolemmal as well as cytosolic sites