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HBEGF — MAPK3

Text-mined interactions from Literome

Bulus et al., Biochem Biophys Res Commun 1999 : HB-EGF also rapidly activated MAPK and induced cyclin D1 in mid-G1 with kinetics similar to TGFalpha
Ellis et al., Biochem J 2001 (MAP Kinase Signaling System...) : Both p42 MAPK activation and HB-EGF mRNA induction were inhibited by genistein, indicating a requirement for an upstream tyrosine kinase activity
Reynolds et al., Hypertension 2002 : HB-EGF induced a time- and concentration dependent phosphorylation of mitogen activated protein kinase ( MAPK ; p42/44 MAPK, extracellular signal regulating kinase [ ERK ] 1/2 )
Kim et al., Cancer Res 2002 (MAP Kinase Signaling System...) : HB-EGF induction of NE differentiation was mediated by a mitogen activated protein kinase ( MAPK ) kinase dependent mechanism, and this process was blocked by p38 MAPK signaling
Mukai et al., Atherosclerosis 2004 : HB-EGF induced phosphorylation of ERK, p38 MAPK and Akt, which were suppressed by ZD1839
Mehta et al., Growth Factors 2007 (MAP Kinase Signaling System) : HB-EGF- and EGF induced HUVEC migration and capillary tube formation were dependent upon activation of PI3K, MAPK and eNOS
Yagi et al., Int J Cancer 2009 (Ovarian Neoplasms) : In addition, the overexpression of HB-EGF in paclitaxel treated SKOV3 cells resulted in modulation of paclitaxel evoked MAPK signaling, including marked activation of ERK and Akt, and minimized activation of JNK and p38 MAPK, indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel
Nakai et al., J Dermatol Sci 2009 : HB-EGF induced phosphorylation of p42/p44 MAPK in a few minutes
Nash et al., Growth Factors 2009 : Western blot analysis showed HB-EGF prevents ethanol from altering MAPK phosphorylation
Sloss et al., Oncogene 2010 (Adenocarcinoma...) : Furthermore, we discover that induction of HB-EGF is dependent on reactive oxygen species and p38-MAPK signaling but not ERK and that the transcription factor SP-1 is involved in NPI-0052 induced HB-EGF transcription
Wright et al., Biol Reprod 2010 : Moreover, HBEGF induced a stronger and more sustained activation of both the mitogen activated protein kinase and phosphoinositol 3 kinase ( PIK3 ) signaling pathways
Kumasawa et al., Asian Pac J Allergy Immunol 2013 : Mitogen activated protein kinase ( MAPK ) regulates leukotriene D4-induced HB-EGF and ADAM12 expression in human airway smooth muscle cells