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MAPK3 — PRL

Text-mined interactions from Literome

Kanasaki et al., Biol Reprod 1999 (Pituitary Neoplasms...) : We examined whether mitogen activated protein ( MAP ) kinase is activated by thyrotropin releasing hormone (TRH) in GH3 cells, and whether MAP kinase activation is involved in secretion of prolactin from these cells
Wang et al., Mol Endocrinol 1999 (Pituitary Neoplasms) : A role for the mitogen activated protein kinase in mediating the ability of thyrotropin releasing hormone to stimulate the prolactin promoter ... Treatment with the MAPKK inhibitor, PD98059, blocked TRH induced activation of MAPK and also reduced TRH induction of a PRL-luciferase reporter gene, confirming that MAPK activation is necessary for TRH effects on PRL gene expression
Barash et al., Mol Cell Endocrinol 1999 : However, a line of evidence suggested that although this kinase phosphorylates PHAS-I in vitro, it does not actively participate in its phosphorylation in vivo : ( a ) the level of insulin needed to enable PRL induced ERK-1/ERK-2 activation was one order of magnitude higher than that needed for PHAS-I phosphorylation ; and ( b ) PD 098059, a MEK-1 inhibitor, completely inhibited insulin dependent, PRL induced ERK-1/ERK-2 activation but had no effect on the PRL induced PHAS-I phosphorylation
Goupille et al., Mol Cell Endocrinol 2000 : Effect of PRL on MAPK activation : negative regulatory role of the C-terminal part of the PRL receptor ... The aim of the present study was to delineate the functional domains of the PRL receptor involved in PRL induced MAPK regulation ... Using various PRL-R mutants of the cytoplasmic domain we found, that the membrane proximal domain is necessary for PRL induced MAPK activation and that the C-terminal part of the receptor exerts a negative regulatory role ... A pharmacological approach, using different types of inhibitors, provided evidence that PRL induced MAPK activation requires both a MEK dependent pathway and a PI3K dependent pathway
Watters et al., Mol Endocrinol 2000 (MAP Kinase Signaling System) : We report here that estrogeninduced PRL expression requires an intact mitogen activated protein kinase ( MAPK ) signal transduction pathway in cultured rat pituitary cells ( PR1 lactotroph and GH3 somatolactotroph cell lines )
Kievit et al., Mol Endocrinol 2001 (Pituitary Neoplasms) : Analysis of the role of the mitogen activated protein kinase in mediating cyclic-adenosine 3',5'-monophosphate effects on prolactin promoter activity ... Treatment of GH ( 3 ) cells with PD98059, an inhibitor of the MAPK pathway, reduced the ability of forskolin to activate a PRL reporter gene, providing evidence that MAPK contributes to cAMP mediated effects on the PRL promoter
Fruchtman et al., Comp Biochem Physiol B Biochem Mol Biol 2001 : The specific MAPK inhibitor, PD98059, blocked IGF-I evoked PRL release as well as GH release inhibition over an 18-20-h incubation
Ezzat et al., Biochem Biophys Res Commun 2001 (Breast Neoplasms) : This soluble FGFR4 isoform ( sFGFR4 ) abrogates the effect of FGF-1 induced MAPK phosphorylation and PRL gene activation
Dogusan et al., J Neuroimmunol 2001 (Autoimmune Diseases...) : p38 MAPK ( but not p42/p44 MAPK ) was activated by PRL in both leukocyte populations
Acosta et al., Mol Endocrinol 2003 : We initially observed that PRL dependent activation of focal adhesion kinase ( Fak ), Erk1/2 , and cell proliferation was mediated by c-Src in T47D cells, because expression of a dominant negative form of c-Src ( SrcDM, K295A/Y527F ) blocked the PRL dependent effects ... Expression of Fak mutant Y397F abrogated PRL dependent activation of Fak, Erk1/2 , and thymidine incorporation, but had no effect on p70S6K and Akt kinases ... MAPK kinase 1/2 ( Mek1/2 ) inhibitor PD184352 blocked PRL induced stimulation of Erk1/2 and cell proliferation ; however, p70S6K and Akt activation were unaffected ... The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 abolished cell proliferation and activation of p70S6K and Akt ; however, PRL dependent activation of Erk1/2 was not modified
Amaral et al., Horm Metab Res 2003 : PRL also induced JAK2, SHC, ERK1 and ERK2 phosphorylation in neonatal islets, demonstrating that PRL can activate MAPK
Domínguez-Cáceres et al., Oncogene 2004 : Stimulation of W53 cell proliferation by PRL required activation of MAPK , as the Mek1/2 inhibitor PD184352 eliminated Erk1/2 stimulation, cell proliferation, and expression of c-Fos mRNA ... However, it reinforced PRL activation of Erk1/2
Lee et al., Cancer Res 2005 (MAP Kinase Signaling System) : 16-kDa PRL effectively inhibited IL-1beta-inducible p38 MAPK phosphorylation, resulting in blocking Stat1 serine phosphorylation, its subsequent nuclear translocation and activation of the Stat1 target gene IRF-1
Huang et al., Oncogene 2006 (Breast Neoplasms) : Both PRL and EGF caused robust signaling in T47D cells ; PRL acutely activated JAK2, signal transducer and activator of transcription-5 ( STAT5 ), and extracellular signal regulated kinase-1 and -2 ( ERK1 and ERK2 ), whereas EGF caused EGFR activation and consequent src homology collagen (SHC) activation and ERK activation
Kanda et al., Endocrinology 2007 (MAP Kinase Signaling System...) : Inhibitors of Janus kinase ( JAK ), p38 MAPK, and MAPK/ERK kinase (MEK) suppressed prolactin- plus IFN-gamma induced CXCL9, CXCL10, and CXCL11 production and NF-kappaB, STAT1, and IRF-1 activities ... Prolactin induced phosphorylation of JAK2 and ERK, whereas IFN-gamma induced phosphorylation of JAK1, JAK2, and p38 MAPK
Blume et al., Endocrinology 2009 : Prolactin activates mitogen activated protein kinase signaling and corticotropin releasing hormone transcription in rat hypothalamic neurons
Wagner et al., Cell Physiol Biochem 2009 (MAP Kinase Signaling System) : Prolactin induces MAPK signaling in neural progenitors without alleviating glucocorticoid induced inhibition of in vitro neurogenesis
Matzkin et al., Mol Cell Endocrinol 2012 (MAP Kinase Signaling System) : Our studies suggest that PRL induces COX2/PGs in hamster Leydig cells through IL-1ß and activation of P38-MAPK and JAK2
Piccoletti et al., Biochem J 1994 : Rapid stimulation of mitogen activated protein kinase of rat liver by prolactin
Carey et al., Arch Biochem Biophys 1995 (Lymphoma) : Inasmuch as lactogen signaling may involve sequential activation of protein kinases, the effect of Prl on the well characterized mitogen activated protein kinase ( MAPK ) and S6 kinase ( S6K ), the enzyme responsible for S6 phosphorylation in vivo, and their relationship to Nb2 macromolecular biosynthesis and mitogenesis were investigated
Johnson et al., J Biol Chem 1996 : Prolactin inhibits epidermal growth factor induced Ras-MAPK signaling in mammary epithelial cells ... To determine the effects of PRL on EGF induced MAPK activation and phosphorylation, MAPK or phosphotyrosine ( Tyr ( P ) ) was immunoprecipitated from normal murine mammary epithelial ( NMuMG ) cells treated with PRL ( 100 ng/ml ) and/or EGF ( 10 ng/ml ) for 10-min periods ... The studies demonstrate that PRL either directly or indirectly inhibits the ability of EGF to induce EGF-R association with Grb2, to activate Ras, and to activate and phosphorylate MAPK
Rao et al., Cell Growth Differ 1995 (Lymphoma, T-Cell) : Rapid activation of mitogen activated protein kinase and p21ras by prolactin and interleukin 2 in rat Nb2 node lymphoma cells
Mitev et al., Biochem Pharmacol 1996 : From these data, it can be concluded that ( 1 ) the stimulation of CKII by prolactin in Nb2 cells is concomitant with cell multiplication : ( 2 ) MAPK stimulation is not necessary for prolactin to induce Nb2 cell multiplication ; and ( 3 ) PKC is stimulated in mammary and Nb2 cells, but this stimulation is not required for prolactin to stimulate casein, c-myc, beta-actin and stathmin gene expression and Nb2 cell division
Nohara et al., Biochem Biophys Res Commun 1997 (Leiomyoma...) : Prolactin stimulates mitogen activated protein kinase in human leiomyoma cells ... Moreover, the regulation of mitogen activated protein ( MAP ) kinase by PRL in leiomyoma derived SMC was investigated