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MAPK3 — PTPN1
Text-mined interactions from Literome
Egawa et al., J Biol Chem 2001
(Carcinoma, Hepatocellular...) :
In both cells,
PTP1B overexpression blocked insulin stimulated tyrosine phosphorylation of the insulin receptor and IRS-1 by more than 70 % and
resulted in a significant inhibition of the association between IRS-1 and the p85 subunit of phosphatidylinositol 3-kinase and Akt phosphorylation as well as
mitogen activated protein kinase phosphorylation
Shimizu et al., Endocrinology 2002
:
Mechanism for differential
effect of
protein-tyrosine phosphatase 1B on Akt versus
mitogen activated protein kinase in 3T3-L1 adipocytes ... Overexpression of a wild-type
PTP1B in L1 adipocytes as well as in L6 myocytes,
led to a profound decrease in insulin stimulated phosphorylation of
MAPK
Nakamura et al., Circ Res 2008
(Disease Models, Animal...) :
In ECs, overexpression of PTP1B, but not catalytically inactive mutant
PTP1B-C/S ,
inhibits VEGF induced phosphorylation of VEGFR2 and
extracellular signal regulated kinase 1/2 , as well as EC proliferation, whereas knockdown of PTP1B by small interfering RNA enhances these responses, suggesting that PTP1B negatively regulates VEGFR2 signaling in ECs ... VEGF induced p38
mitogen activated protein kinase phosphorylation and EC migration are not
affected by
PTP1B overexpression or knockdown
Venkatesan et al., FASEB J 2008
:
Interestingly, resveratrol
increased the activity of protein tyrosine phosphatase
PTP1B , which dephosphorylates PDGF stimulated phosphorylation at tyrosine-751 and tyrosine-716 on PDGFR with concomitant reduction in Akt and
Erk1/2 kinase activity
Wang et al., Med Oncol 2012
(Disease Progression...) :
Overexpression of
PTP1B promoted the proliferation and in vivo tumorigenesis of MKN45 cells and also
increased the phosphorylation levels of Akt,
Erk1/2 , and FAK and the activity of Src
Liu et al., Mol Cell Biol 1998
(Cell Transformation, Neoplastic) :
Expression of
WT-PTP1B reduces formation of p130Cas-Crk complexes and
inhibits mitogen activated protein kinase activation by Src and Crk