◀ Back to MAPK3
MAPK3 — RHOA
Pathways - manually collected, often from reviews:
-
BioCarta trefoil factors initiate mucosal healing:
RhoA (RHOA)
→
ERK1 (MAPK3)
(modification, activates)
-
NCI Pathway Database S1P2 pathway:
Erk1-2 (MAPK3/MAPK1)
→
RhoA (RHOA)
(modification, collaborate)
An et al., J Biol Chem 2000, Arikawa et al., J Biol Chem 2003, Gonda et al., Biochem J 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL2-mediated signaling events:
Erk1-2-active (MAPK3/MAPK1)
→
RHOA/GTP complex (RHOA)
(transcription, activates)
Satoh et al., J Biol Chem 1992, Arnaud et al., Biochem J 2004, Shibuya et al., Cell 1992*, Kawahara et al., Proc Natl Acad Sci U S A 1995*
Evidence: mutant phenotype, reporter gene, other species
Text-mined interactions from Literome
Vial et al., Cancer Cell 2003
(Colonic Neoplasms...) :
ERK-MAPK signaling coordinately
regulates activity of Rac1 and
RhoA for tumor cell motility
Calleros et al., Apoptosis 2006
:
Finally, overexpression of the dominant negative
N19RhoA inhibited p38
MAPK phosphorylation and apoptosis induced by low cholesterol levels
Khwaja et al., Kidney Int 2006
:
GGTI 298 increased cytosolic expression of RhoA, prevented
RhoA activation, and
inhibited the activation of
Erk1/2 and the survival protein Akt
Chapados et al., Circ Res 2006
(Disease Progression...) :
Indeed, SMCs on denatured collagen possessed higher levels of RhoA activity than those on native collagen, and blocking
RhoA or ROCK activities
attenuated SMC spreading,
ERK1/2 activity, and TN-C expression in SMCs on denatured collagen
Horowitz et al., Am J Physiol Gastrointest Liver Physiol 2007
(Crohn Disease...) :
The
RhoA inhibitor C3 exoenzyme and the ROCK inhibitor Y-27632 both
attenuated TNF-alpha/lipopolysaccharide induced
MAPK activation and blocked AR expression in HIMEC
Yano et al., Circ Res 2007
(Inflammation) :
However,
DN-RhoA and DN-Cdc42
activated p38
MAPK , but not ERK1/2
Zeidan et al., Cardiovasc Res 2008
(Cardiomegaly) :
Leptin induced cardiomyocyte hypertrophy involves selective caveolae and
RhoA/ROCK dependent p38
MAPK translocation to nuclei
Spindler et al., J Immunol 2010
(Disease Models, Animal...) :
Several intracellular signaling pathways, such as
p38MAPK activation and
RhoA inhibition , have been demonstrated to be altered following autoantibody binding and to be causally involved in loss of keratinocyte cohesion
Shatanawi et al., Am J Physiol Cell Physiol 2011
:
ANG II also elevates active
RhoA levels and
induces phosphorylation of p38
MAPK
Moey et al., J Pharmacol Exp Ther 2011
(Cardiomegaly) :
These results demonstrate a potent inhibitory effect of ginseng against leptin induced cardiac hypertrophy, an effect associated with prevention of
p115RhoGEF-RhoA/ROCK dependent p38
MAPK activation
Yang et al., PloS one 2012
(MAP Kinase Signaling System) :
The results revealed that Zol markedly down-regulated active
RhoA stimulated by Ang II and
inhibited the phosphorylation of
Erk1/2 and JNK
Li et al., Cell death & disease 2013
:
The inhibited
RhoA/ROCK1 signalling
enhanced the phosphorylation of
Erk1/2 in a Mek1/2 independent manner