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MAPK3 — TPO

Text-mined interactions from Literome

Gaur et al., Blood 2001 : By using avian retroviruses to express wild-type or mutant Mpl on the surfaces of primary megakaryocyte-lineage cells, it was demonstrated that ( 1 ) the 10 membrane-proximal, cytoplasmic amino acids of Mpl are required for TPO induced proliferation ; ( 2 ) Y582F mutation confers a proliferative advantage over wild-type Mpl and imparts a constitutive anti-apoptotic signal ; ( 3 ) truncating the 50 C-terminal Mpl amino acids reduces but does not eliminate TPO induced mitogen activated protein kinase activation, yet it does not alter the synergistic effect of stem cell factor on TPO induced proliferation ; and ( 4 ) TPO induced proliferation of early, primary megakaryocyte-lineage cells does not require Stat-5 phosphorylation
Sauer et al., Cytokine 2001 (Leukemia, Megakaryoblastic, Acute) : We investigated the effect of TPO on activation of cAMP dependent protein kinase (PKA) and its involvement in MAPK signalling in human megakaryoblastic leukaemia CMK cells ... The activation of TPO induced MAPK activation and the effect of the PKA inhibitor H-89 was measured using immunoblotting with a monoclonal anti-pERK antibody ... In addition, H-89 partly blocked TPO induced MAPK activation in CMK cells ... This signal transduction route seems to be involved in TPO induced MAPK signaling
Tong et al., J Exp Med 2004 : The absence of Lnk caused enhanced and prolonged Tpo induction of STAT3, STAT5, Akt, and MAPK signaling pathways in CD41+ megakaryocytes
Baker et al., Cardiovasc Res 2008 (Myocardial Infarction...) : Tpo activated JAK-2 ( Janus kinase-2 ) and p44 MAPK ( mitogen activated protein kinase ) during reperfusion but not prior to ischaemia
Takizawa et al., Exp Hematol 2008 (MAP Kinase Signaling System) : Erk1/2 phosphorylation induced by TPO was augmented and prolonged in Lnk ( -/- ) MKs while activation of signal transducers and activators of transcription ( Stat ) 3, Stat5, and Akt was normal
Tashiro et al., Stem Cells Dev 2012 : Furthermore, Lnk inhibition by the overexpression of the DN-Lnk gene augmented the TPO induced phosphorylation of Erk1/2 and Akt, indicating the enhanced sensitivity to TPO
Dorsch et al., J Exp Med 1997 : This mutant still mediates TPO induced phosphorylation of Shc, Vav, mitogen activated protein kinase ( MAPK ) and Raf-1 as well as induction of c-fos and c-myc, although at somewhat reduced levels