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MSH2 — RELA

Text-mined interactions from Literome

Ichiyama et al., Brain Res 1999 (Brain Diseases...) : The effects of alpha-MSH on NF-kappaB and IkappaBalpha were paralleled by pretreatment with alpha-MSH11-13
Ichiyama et al., J Neuroimmunol 1999 (Acute Disease...) : Electrophoretic mobility shift assays of nuclear extracts from the murine foot pad injected with TNF-alpha demonstrated that centrally administered alpha-MSH does inhibit NF-kappaB activation ... Centrally administered alpha-MSH inhibited peripheral NF-kappaB activation and IkappaBalpha degradation even in mice with nonfunctional melanocortin 1 receptors (MC1R) ... These findings indicate that alpha-MSH can act centrally to inhibit NF-kappaB activation in peripheral acute inflammation via a descending neural pathway
Brzoska et al., Ann N Y Acad Sci 1999 : Furthermore, we determined the effect of alpha-MSH on the IL-1 beta induced activation of the nuclear factor kappa B (NF kappa B) -- a major transcription factor for chemokine genes
Böhm et al., Ann N Y Acad Sci 1999 : alpha-MSH also induces activation of NF-kappa B but does not modulate DNA binding on costimulation with IL-1 beta
Gupta et al., Kidney Int 2000 : To test the hypothesis that alpha-MSH inhibits the expression of inducible trans activating factors involved in NOS2 regulation, we used RAW 264.7 macrophage cells to examine the effects of alpha-MSH on the activation of nuclear factor-kappaB (NF-kappaB) and CCAAT/enhancer binding protein-beta ( C/EBPbeta ), trans acting factors known to be involved in LPS + interferon (IFN)-gamma induction of the NOS2 gene ... Gel shift assays were performed to identify NF-kappaB and C/EBP DNA binding activities in LPS + IFN-gamma treated RAW 264.7 cells in the presence and absence of alpha-MSH
Mandrika et al., Biochem Pharmacol 2001 : We investigated the effects of alpha-MSH, alpha-MSH ( 1-10 ), and alpha-MSH ( 11-13 ) on NO production and nuclear factor-kappaB (NF-kappaB) translocation in RAW 264.7 macrophages
Catania et al., Ann N Y Acad Sci 2000 : At the molecular level, alpha-MSH inhibited activation of the transcription factor NF-kappa B known to enhance HIV expression
Moustafa et al., J Invest Dermatol 2002 : We have previously shown that alpha-MSH can inhibit tumor necrosis factor-alpha stimulated intercellular adhesion molecule 1 upregulation and nuclear factor kappaB (NFkappaB) transcription factor activation in melanocyte and melanoma cells ... alpha-MSH , L-Lys-L-Pro-L-Val, and L-Lys-L-Pro-D-Val all significantly inhibited tumor necrosis factor alpha stimulated NFkappaB activation, whereas ACTH 1-17 and 1-39 did not, in the HaCaT keratinocytes
Teare et al., Neuroreport 2003 : We investigated the ability of alpha-MSH to inhibit the activation of NF-kappaB in cultured rat primary olfactory ensheathing cells stimulated with tumour necrosis factor-alpha or gamma-interferon
Hill et al., Peptides 2006 : The present study confirms MC1R expression in cultured human dermal fibroblasts and reports that the MSH peptides alpha-MSH and KP ( -D- ) V inhibit TNF-alpha stimulated NF-kappaB activity and ICAM-1 upregulation, consistent with an anti-inflammatory role