◀ Back to LEP

LEP — MUC22

Text-mined interactions from Literome

Plaisancie et al., Am J Physiol Gastrointest Liver Physiol 2006 : Here, we studied the effects of leptin on colonic mucus secretion and rat mucin 2 ( rMuc2 ) expression ... The effects of leptin alone or in association with protein kinase C ( PKC ) and phosphatidylinositol 3-kinase (PI3K) inhibitors on mucin secreted by human mucus secreting HT29-MTX cells were determined ... In human colonic goblet-like HT29-MTX cells expressing leptin receptors, leptin increased mucin secretion by activating PKC- and PI3K dependent pathways
Slomiany et al., J Physiol Pharmacol 2007 : Moreover, potentiation in the effect of leptin on the LPS induced decrease in mucin synthesis was attained with cPLA(2) inhibitor, MAFP as well as PAF receptor antagonist, BN52020
El Homsi et al., Am J Physiol Gastrointest Liver Physiol 2007 (MAP Kinase Signaling System) : We recently showed that luminal leptin strongly stimulated mucin secretion in vivo in rat colon ... Finally, pathway inhibition experiments suggest that leptin increased mucin expression by activating PKC-, phosphatidyl inositol 3-kinase-, and MAPK dependent pathways but not the JAK/STAT pathway
Motawi et al., J Biomed Sci 2008 : Leptin significantly increased mucin and tissue NO, restored GR and SOD activities and up-regulated GPx activity
Song et al., Laryngoscope 2010 (Nasal Polyps) : We aimed to demonstrate the differential expression of leptin receptors in normal human nasal mucosa and nasal polyps, and to elucidate the effects of leptin on mucin gene expression in human nasal polyp epithelial cells ... Leptin induced mucin expression was inhibited by the leptin receptor antagonist
Woo et al., Exp Lung Res 2010 (MAP Kinase Signaling System) : We investigated the effects of leptin on mucin expression in human airway epithelial cells and the signaling pathways