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CD40LG — MAPK11
Pathways - manually collected, often from reviews:
-
NCI Pathway Database CD40/CD40L signaling:
p38alpha-beta (MAPK14/MAPK11)
→
CD40/CD40L (trimer)/TRAF6 complex (CD40LG-CD40-TRAF6)
(modification, collaborate)
Pullen et al., J Biol Chem 1999, Davies et al., Mol Cell Biol 2005
Evidence: mutant phenotype, assay
-
NCI Pathway Database CD40/CD40L signaling:
CD40/CD40L (trimer)/TRAF2 (trimer)/MEKK1 complex (CD40LG-CD40-TRAF2-MAP3K1)
→
p38alpha-beta-active (MAPK14/MAPK11)
(modification, activates)
Haxhinasto et al., J Immunol 2002, Jabara et al., Immunity 2002, Gallagher et al., Nat Immunol 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database CD40/CD40L signaling:
CD40/CD40L (trimer)/TRAF2 (trimer)/MEKK1 complex (CD40LG-CD40-TRAF2-MAP3K1)
→
p38alpha-beta (MAPK14/MAPK11)
(modification, activates)
Haxhinasto et al., J Immunol 2002, Jabara et al., Immunity 2002, Gallagher et al., Nat Immunol 2007
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Chakrabarti et al., J Biol Chem 2007
(Inflammation) :
These data support a mechanism whereby redox-sensitive
CD40-CD40L interactions
induce activation of Akt and p38
MAPK , leading to stimulation of NFkappaB and enhanced synthesis of CD40L and MCP1
Zhao et al., Invest Ophthalmol Vis Sci 2010
(Graves Ophthalmopathy...) :
CD40L induced the phosphorylation of p38
MAPK , extracellular regulated kinase1/2 ( ERK1/2 ), c-Jun NH2-terminal kinase (JNK), and IkappaB and the activation of NF-kappaB
Jiang et al., Circ Res 1996
:
Thrombin and
TRAP also
activate mitogen activated protein kinase ( MAPK ) in cultured neonatal rat ventricular myocytes ... Pretreatment with phorbol 12-myristate 13-acetate ( PMA ) to downregulate protein kinase C ( PKC ) attenuates thrombin- and
TRAP dependent activation of
MAPK , although small and equivalent effects of thrombin and TRAP to stimulate MAPK persist in PMA pretreated cells