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MAPK11 — PDGFA
Text-mined interactions from Literome
Hanada et al., Biol Pharm Bull 1999
:
PDGF-AB stimulated
mitogen activated protein ( MAP ) kinases , and PDGF induced MAP kinase activation was inhibited by genistein
Ricono et al., American journal of physiology. Renal physiology 2002
(MAP Kinase Signaling System) :
PDGF AA and PDGF BB significantly
increased the activities of phosphatidylinositol 3-kinase (PI 3-K) and mitogen activated protein kinase (
MAPK ) ... Although
PDGF AA stimulates PI 3-K and
MAPK activity, it is not mitogenic and only modestly chemotactic
Liu et al., Surgery 2002
:
In contrast, C3 did not significantly affect DNA synthesis in
response to
PDGF-AB or activation of
mitogen activated protein kinase , a signaling mediator of PDGF stimulated proliferation
Oak et al., Arterioscler Thromb Vasc Biol 2003
(MAP Kinase Signaling System) :
Short-term and long-term treatment of VSMCs with RWPCs markedly reduced
PDGFAB induced production of reactive oxygen species and phosphorylation of p38
MAPK
Lubinus et al., J Biol Chem 1994
:
We investigated the
effects of
platelet derived growth factor (PDGF) AA and PDGF BB on activation of
MAPK in human dermal fibroblasts, and asked whether its activation correlates with proliferative responses of human fibroblasts to PDGF AA and PDGF BB ... Thus both
PDGF AA and PDGF BB are potent
activators of
MAPK in human dermal fibroblasts
Karenberg et al., Exp Cell Res 1994
:
Whereas PDGF-BB effectively stimulated all three events,
PDGF-AA failed to stimulate the phosphatidylinositol-3 kinase activity, but
stimulated the
mitogen activated protein kinase to a maximum extent