UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	CBP6	YBR120C	427	n/a	chrII 480,679	Mitochondrial protein required for translation of the COB mRNA forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
2	SIR1	YKR101W	427	n/a	chrXI 641,522	Protein involved in repression of transcription at the silent mating-type loci HML and HMR recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain binds to centromeric chromatin
3	NPR1	YNL183C	427	n/a	chrXIV 294,323	Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation phosphorylates Aly2p
4	YCR007C	YCR007C	427	n/a	chrIII 126,370	Putative integral membrane protein, member of DUP240 gene family YCR007C is not an essential gene
5	TRX3	YCR083W	427	n/a	chrIII 259,769	Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p
6	PEX3	YDR329C	427	n/a	chrIV 1,126,932	Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs anchors peroxisome retention factor Inp1p at the peroxisomal membrane interacts with Pex19p
7	SKN1	YGR143W	427	n/a	chrVII 776,350	Protein involved in sphingolipid biosynthesis type II membrane protein with similarity to Kre6p
8	YBR225W	YBR225W	427	n/a	chrII 671,978	Putative protein of unknown function non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components
9	ECM34	YHL043W	427	n/a	chrVIII 15,157	Putative protein of unknown function member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
10	YHR054C	YHR054C	427	n/a	chrVIII 213,717	Putative protein of unknown function
11	YHR080C	YHR080C	427	n/a	chrVIII 264,819	Protein of unknown function that may interact with ribosomes, based on co-purification experiments the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
12	YHR202W	YHR202W	427	n/a	chrVIII 503,292	Putative protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
13	CYC2	YOR037W	427	n/a	chrXV 402,105	Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space exhibits redox activity in vitro likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
14	YJL206C	YJL206C	427	n/a	chrX 48,797	Putative protein of unknown function similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family mRNA is weakly cell cycle regulated, peaking in S phase induced rapidly upon MMS treatment
15	AST2	YER101C	427	n/a	chrV 361,148	Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions
16	UBP9	YER098W	427	n/a	chrV 356,598	Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
17	FMP10	YER182W	427	n/a	chrV 552,892	Putative protein of unknown function the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
18	PCL7	YIL050W	427	n/a	chrIX 259,341	Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p involved in glycogen metabolism, expression is cell-cycle regulated
19	IMA4	YJL221C	427	n/a	chrX 17,651	Alpha-glucosidase with broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides member of IMA isomaltase family not required for isomaltose utilization, but Ima4p overexpression allows the ima1 null mutant to grow on isomaltose
20	IMA3	YIL172C	427	n/a	chrIX 17,668	Alpha-glucosidase with broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides member of IMA isomaltase family not required for isomaltose utilization, but Ima3p overexpression allows the ima1 null mutant to grow on isomaltose
21	POG1	YIL122W	427	n/a	chrIX 131,137	Nuclear chromatin-associated protein of unknown function overexpression promotes recovery from pheromone induced arrest and suppresses the stress sensitivity caused by a mutation in the E3 ubiquitin ligase Rsp5p binds upstream of BAR1 and cell cycle-related genes potential Cdc28p substrate SBF regulated
22	PCI8	YIL071C	427	n/a	chrIX 229,327	Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain
23	PAU15	YIR041W	427	n/a	chrIX 434,116	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
24	AZF1	YOR113W	427	n/a	chrXV 535,447	Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance
25	LSB6	YJL100W	427	n/a	chrX 238,174	Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
26	SNO3	YFL060C	427	n/a	chrVI 10,635	Protein of unknown function, nearly identical to Sno2p expression is induced before the diauxic shift and also in the absence of thiamin
27	YJR107W	YJR107W	427	n/a	chrX 627,833	Putative protein of unknown function has sequence or structural similarity to lipases
28	JHD2	YJR119C	427	n/a	chrX 645,397	JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4) removes methyl groups specifically added by Set1p methyltransferase protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation
29	STR2	YJR130C	427	n/a	chrX 666,177	Cystathionine gamma-synthase, converts cysteine into cystathionine
30	HXT16	YJR158W	427	n/a	chrX 733,291	Protein of unknown function with similarity to hexose transporter family members, expression is repressed by high levels of glucose
31	YDL183C	YDL183C	427	n/a	chrIV 131,352	Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system non-essential gene
32	KEL2	YGR238C	427	n/a	chrVII 967,363	Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p localizes to regions of polarized growth potential Cdc28p substrate
33	PCL10	YGL134W	427	n/a	chrVII 256,313	Pho85p cyclin recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
34	YGL081W	YGL081W	427	n/a	chrVII 357,858	Putative protein of unknown function non-essential gene interacts genetically with CHS5, a gene involved in chitin biosynthesis
35	TAM41	YGR046W	427	n/a	chrVII 585,473	Mitochondrial protein involved in protein import into the mitochondrial matrix maintains the functional integrity of the TIM23 protein translocator complex viability of null mutant is strain-dependent mRNA is targeted to the bud
36	SPO1	YNL012W	427	n/a	chrXIV 610,675	Meiosis-specific prospore protein required for meiotic spindle pole body duplication and separation required to produce bending force necessary for proper prospore membrane assembly during sporulation has similarity to phospholipase B
37	ATG4	YNL223W	427	0	chrXIV 228,112	Conserved cysteine protease required for autophagy cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation
38	HXT15	YDL245C	427	n/a	chrIV 12,508	Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
39	MFM1	YPL060W	427	n/a	chrXVI 435,143	Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential indirectly affects splicing of group II introns functionally and structurally related to Mrs2p
40	YPL109C	YPL109C	427	n/a	chrXVI 346,326	Putative protein of unknown function the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
41	MTG1	YMR097C	427	n/a	chrXIII 459,975	Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
42	TPP1	YMR156C	427	n/a	chrXIII 570,658	DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks has similarity to the l-2-haloacid dehalogenase superfamily
43	ATG16	YMR159C	427	n/a	chrXIII 574,702	Conserved protein that interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy
44	YDR124W	YDR124W	427	n/a	chrIV 700,802	Putative protein of unknown function non-essential gene expression is strongly induced by alpha factor
45	ECM18	YDR125C	427	n/a	chrIV 702,077	Protein of unknown function, similar to Rlp24p
46	YMR034C	YMR034C	427	n/a	chrXIII 340,070	Putative transporter, member of the SLC10 carrier family identified in a transposon mutagenesis screen as a gene involved in azole resistance YMR034C is not an essential gene
47	YDR282C	YDR282C	427	n/a	chrIV 1,024,133	Putative protein of unknown function
48	UPS1	YLR193C	427	n/a	chrXII 540,272	Mitochondrial intermembrane space protein that regulates mitochondrial cardiolipin levels, null has defects in Mgm1p processing, integrity of mitochondrial inner membrane complexes, and mitochondrial morphology ortholog of human PRELI
49	YLR271W	YLR271W	427	n/a	chrXII 683,149	Putative protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
50	PUS5	YLR165C	427	n/a	chrXII 494,876	Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA not essential for viability