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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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ANAPC4 — PCNA

Text-mined interactions from Literome

Zachariae et al., Curr Opin Cell Biol 1999 : Progression through mitosis is controlled by cyclin dependent kinases, which drive cells into metaphase, and by the anaphase promoting complex/cyclosome , a ubiquitin ligase that triggers sister chromatid separation and exit from mitosis
Tyson et al., J Theor Biol 2001 : First, we present a simple model of the antagonistic interactions between cyclin dependent kinases and the anaphase promoting complex , which shows how progress through the cell cycle can be thought of as irreversible transitions ( Start and Finish ) between two stable states ( G1 and S-G2-M ) of the regulatory system
Irniger et al., FEBS Lett 2002 : Cyclin proteolysis is triggered by the anaphase promoting complex/cyclosome ( APC/C ), a multi-subunit complex which contains ubiquitin ligase activity
Guardavaccaro et al., Dev Cell 2003 (Infertility, Male) : Furthermore, cyclin A, cyclin B, and Emi1, an inhibitor of the anaphase promoting complex , are stabilized in mitotic beta-Trcp1 ( -/- ) MEFs
Margottin-Goguet et al., Dev Cell 2003 : Progression through mitosis occurs because cyclin B/Cdc2 activation induces the anaphase promoting complex (APC) to cause cyclin B destruction and mitotic exit
Archambault et al., Expert Rev Proteomics 2005 : In the past 5 years, developments in mass spectrometry based proteomics have been applied to the study of protein interactions and post-translational modifications involving key cell cycle regulators such as cyclin dependent kinases and the anaphase promoting complex , as well as effectors such as centrosomes, the kinetochore and DNA replication forks
Ban et al., Dev Cell 2007 : Cyclin dependent kinase 1 (Cdk1) initiates mitosis and later activates the anaphase promoting complex/cyclosome ( APC/C ) to destroy cyclins
Kang et al., Hum Pathol 2009 (Breast Neoplasms...) : Cyclin B proteolysis is triggered by the anaphase promoting complex
Wijnker et al., Plant reproduction 2013 : Progression through meiosis relies on many of the same, or at least homologous, cell cycle regulators that act in mitosis, e.g., cyclin dependent kinases and the anaphase promoting complex/cyclosome