ID:MRP1_HUMAN DESCRIPTION: RecName: Full=Multidrug resistance-associated protein 1; AltName: Full=ATP-binding cassette sub-family C member 1; AltName: Full=Leukotriene C(4) transporter; Short=LTC4 transporter; FUNCTION: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Lung, testis and peripheral blood mononuclear cells. SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. SIMILARITY: Contains 2 ABC transmembrane type-1 domains. SIMILARITY: Contains 2 ABC transporter domains. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MRPID106.html"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/abcc1/"; WEB RESOURCE: Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=P33527";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P33527
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_mrpPathway - Multi-Drug Resistance Factors
Reactome (by CSHL, EBI, and GO)
Protein P33527 (Reactome details) participates in the following event(s):
R-HSA-266070 LTC4 is exported from the cytosol by ABCC1 R-HSA-3095901 ABCC1 transports cytosolic Cbl to extracellular region R-HSA-1454916 The ABCC family mediates organic anion transport R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-382556 ABC-family proteins mediated transport R-HSA-2142753 Arachidonic acid metabolism R-HSA-196849 Metabolism of water-soluble vitamins and cofactors R-HSA-382551 Transport of small molecules R-HSA-8978868 Fatty acid metabolism R-HSA-196854 Metabolism of vitamins and cofactors R-HSA-556833 Metabolism of lipids R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
