Human Gene ABCC5 (ENST00000334444.11_7) from GENCODE V47lift37

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Description: ATP binding cassette subfamily C member 5, transcript variant 1 (from RefSeq NM_005688.4)
Gencode Transcript: ENST00000334444.11_7
Gencode Gene: ENSG00000114770.17_13
Transcript (Including UTRs)
Position: hg19 chr3:183,637,722-183,735,672 Size: 97,951 Total Exon Count: 30 Strand: -
Coding Region
Position: hg19 chr3:183,639,088-183,732,180 Size: 93,093 Coding Exon Count: 29

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:183,637,722-183,735,672)			mRNA (may differ from genome)		Protein (1437 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: MRP5_HUMAN DESCRIPTION: RecName: Full=Multidrug resistance-associated protein 5; AltName: Full=ATP-binding cassette sub-family C member 5; AltName: Full=Multi-specific organic anion transporter C; Short=MOAT-C; AltName: Full=SMRP; AltName: Full=pABC11; FUNCTION: Acts as a multispecific organic anion pump which can transport nucleotide analogs. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: All isoforms are equally expressed in retina. SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. SIMILARITY: Contains 2 ABC transmembrane type-1 domains. SIMILARITY: Contains 2 ABC transporter domains. WEB RESOURCE: Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=O15440";

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ABCC5 Diseases sorted by gene-association score: lymphoblastic leukemia (4)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin C023035 3,4,5,3',4'-pentachlorobiphenyl D000082 Acetaminophen D001564 Benzo(a)pyrene D003300 Copper D003993 Dibutyl Phthalate D004997 Ethinyl Estradiol D005978 Glutathione D015215 Zidovudine D015655 1-Methyl-4-phenylpyridinium more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 37.09 RPKM in Brain - Cerebellum Total median expression: 503.64 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-32.00	110	-0.291	Picture	PostScript	Text
3' UTR	-421.90	1366	-0.309	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR003593 - AAA+_ATPase
IPR003439 - ABC_transporter-like
IPR017871 - ABC_transporter_CS
IPR017940 - ABC_transporter_type1
IPR001140 - ABC_transptr_TM_dom
IPR011527 - ABC_transptrTM_dom_typ1

Pfam Domains:
PF00005 - ABC transporter
PF00664 - ABC transporter transmembrane region

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases
53795 - PEP carboxykinase-like
90123 - ABC transporter transmembrane region

ModBase Predicted Comparative 3D Structure on O15440


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details			Gene Details
Gene Sorter	Gene Sorter			Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0008514 organic anion transmembrane transporter activity GO:0016887 ATPase activity GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0043225 ATPase-coupled anion transmembrane transporter activity Biological Process: GO:0015711 organic anion transport GO:0030213 hyaluronan biosynthetic process GO:0055085 transmembrane transport GO:0099133 ATP hydrolysis coupled anion transmembrane transport Cellular Component: GO:0005886 plasma membrane GO:0005887 integral component of plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	AF146074 - Homo sapiens ABC protein mRNA, complete cds. U83661 - Homo sapiens multidrug resistance protein 5 (MRP5) mRNA, complete cds. AF104942 - Homo sapiens ABC transporter MOAT-C (MOAT-C) mRNA, complete cds. U66687 - Homo sapiens clone EST277145 mRNA sequence. AB209103 - Homo sapiens mRNA for ATP-binding cassette C5 splicing variant A variant protein. AB209454 - Homo sapiens mRNA for Multidrug resistance-associated protein 5 variant protein. BX647245 - Homo sapiens mRNA; cDNA DKFZp686C1782 (from clone DKFZp686C1782). AB005659 - Homo sapiens SMRP mRNA, complete cds. AB019002 - Homo sapiens MRP5 mRNA, complete cds. JD358562 - Sequence 339586 from Patent EP1572962. JD561555 - Sequence 542579 from Patent EP1572962. JD284653 - Sequence 265677 from Patent EP1572962. JD155516 - Sequence 136540 from Patent EP1572962. JD544896 - Sequence 525920 from Patent EP1572962. JD137115 - Sequence 118139 from Patent EP1572962. JD534282 - Sequence 515306 from Patent EP1572962. JD098082 - Sequence 79106 from Patent EP1572962. JD146830 - Sequence 127854 from Patent EP1572962. JD459128 - Sequence 440152 from Patent EP1572962. BC140771 - Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 5, mRNA (cDNA clone MGC:176448 IMAGE:9021639), complete cds. BC144495 - Homo sapiens cDNA clone IMAGE:9053022, containing frame-shift errors. JD524872 - Sequence 505896 from Patent EP1572962. JD535146 - Sequence 516170 from Patent EP1572962. JD441803 - Sequence 422827 from Patent EP1572962. JD455662 - Sequence 436686 from Patent EP1572962. DQ601269 - Homo sapiens piRNA piR-39335, complete sequence. LF338669 - JP 2014500723-A/146172: Polycomb-Associated Non-Coding RNAs. JD066442 - Sequence 47466 from Patent EP1572962. JD298399 - Sequence 279423 from Patent EP1572962. LF338670 - JP 2014500723-A/146173: Polycomb-Associated Non-Coding RNAs. AY196484 - Homo sapiens ATP-binding cassette C5 splicing variant A (ABCC5) mRNA, complete cds; alternatively spliced. JD555084 - Sequence 536108 from Patent EP1572962. JD064936 - Sequence 45960 from Patent EP1572962. LF338671 - JP 2014500723-A/146174: Polycomb-Associated Non-Coding RNAs. LF338672 - JP 2014500723-A/146175: Polycomb-Associated Non-Coding RNAs. LF338674 - JP 2014500723-A/146177: Polycomb-Associated Non-Coding RNAs. LF338677 - JP 2014500723-A/146180: Polycomb-Associated Non-Coding RNAs. LF338679 - JP 2014500723-A/146182: Polycomb-Associated Non-Coding RNAs. LF338680 - JP 2014500723-A/146183: Polycomb-Associated Non-Coding RNAs. LF338681 - JP 2014500723-A/146184: Polycomb-Associated Non-Coding RNAs. LF338682 - JP 2014500723-A/146185: Polycomb-Associated Non-Coding RNAs. LF338683 - JP 2014500723-A/146186: Polycomb-Associated Non-Coding RNAs. LF338685 - JP 2014500723-A/146188: Polycomb-Associated Non-Coding RNAs. LF338688 - JP 2014500723-A/146191: Polycomb-Associated Non-Coding RNAs. LF338691 - JP 2014500723-A/146194: Polycomb-Associated Non-Coding RNAs. LF338692 - JP 2014500723-A/146195: Polycomb-Associated Non-Coding RNAs. LF338693 - JP 2014500723-A/146196: Polycomb-Associated Non-Coding RNAs. LF338696 - JP 2014500723-A/146199: Polycomb-Associated Non-Coding RNAs. BC050744 - Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 5, mRNA (cDNA clone IMAGE:6091533), complete cds. BC142670 - Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 5, mRNA (cDNA clone IMAGE:40148179), complete cds. BC142719 - Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 5, mRNA (cDNA clone IMAGE:40148870), complete cds. AY754874 - Homo sapiens ABCC5 variant 2 (ABCC5) mRNA, complete cds, alternatively spliced. AY754875 - Homo sapiens ABCC5 variant 3 (ABCC5) mRNA, complete cds, alternatively spliced. AY754876 - Homo sapiens ABCC5 variant 4 (ABCC5) mRNA, complete cds, alternatively spliced. LF385114 - JP 2014500723-A/192617: Polycomb-Associated Non-Coding RNAs. LF338708 - JP 2014500723-A/146211: Polycomb-Associated Non-Coding RNAs. LF338709 - JP 2014500723-A/146212: Polycomb-Associated Non-Coding RNAs. BC015334 - Homo sapiens, clone IMAGE:4391654, mRNA, partial cds. BC051358 - Homo sapiens cDNA clone IMAGE:6645354, partial cds. DL492066 - Novel nucleic acids. LF338717 - JP 2014500723-A/146220: Polycomb-Associated Non-Coding RNAs. DL490615 - Novel nucleic acids. LF338718 - JP 2014500723-A/146221: Polycomb-Associated Non-Coding RNAs. JD532379 - Sequence 513403 from Patent EP1572962. JD400531 - Sequence 381555 from Patent EP1572962. MA620691 - JP 2018138019-A/192617: Polycomb-Associated Non-Coding RNAs. MA574246 - JP 2018138019-A/146172: Polycomb-Associated Non-Coding RNAs. MA574247 - JP 2018138019-A/146173: Polycomb-Associated Non-Coding RNAs. MA574248 - JP 2018138019-A/146174: Polycomb-Associated Non-Coding RNAs. MA574249 - JP 2018138019-A/146175: Polycomb-Associated Non-Coding RNAs. MA574251 - JP 2018138019-A/146177: Polycomb-Associated Non-Coding RNAs. MA574254 - JP 2018138019-A/146180: Polycomb-Associated Non-Coding RNAs. MA574256 - JP 2018138019-A/146182: Polycomb-Associated Non-Coding RNAs. MA574257 - JP 2018138019-A/146183: Polycomb-Associated Non-Coding RNAs. MA574258 - JP 2018138019-A/146184: Polycomb-Associated Non-Coding RNAs. MA574259 - JP 2018138019-A/146185: Polycomb-Associated Non-Coding RNAs. MA574260 - JP 2018138019-A/146186: Polycomb-Associated Non-Coding RNAs. MA574262 - JP 2018138019-A/146188: Polycomb-Associated Non-Coding RNAs. MA574265 - JP 2018138019-A/146191: Polycomb-Associated Non-Coding RNAs. MA574268 - JP 2018138019-A/146194: Polycomb-Associated Non-Coding RNAs. MA574269 - JP 2018138019-A/146195: Polycomb-Associated Non-Coding RNAs. MA574270 - JP 2018138019-A/146196: Polycomb-Associated Non-Coding RNAs. MA574273 - JP 2018138019-A/146199: Polycomb-Associated Non-Coding RNAs. MA574285 - JP 2018138019-A/146211: Polycomb-Associated Non-Coding RNAs. MA574286 - JP 2018138019-A/146212: Polycomb-Associated Non-Coding RNAs. MA574294 - JP 2018138019-A/146220: Polycomb-Associated Non-Coding RNAs. MA574295 - JP 2018138019-A/146221: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein O15440 (Reactome details) participates in the following event(s): R-HSA-2142859 Growing HA is extruded from the cell by ABCC5 R-HSA-1454916 The ABCC family mediates organic anion transport R-HSA-2142850 Hyaluronan biosynthesis and export R-HSA-382556 ABC-family proteins mediated transport R-HSA-2142845 Hyaluronan metabolism R-HSA-382551 Transport of small molecules R-HSA-1630316 Glycosaminoglycan metabolism R-HSA-71387 Metabolism of carbohydrates R-HSA-1430728 Metabolism

Other Names for This Gene


	Alternate Gene Symbols: B9EIQ2, ENST00000334444.1, ENST00000334444.10, ENST00000334444.2, ENST00000334444.3, ENST00000334444.4, ENST00000334444.5, ENST00000334444.6, ENST00000334444.7, ENST00000334444.8, ENST00000334444.9, MRP5, MRP5_HUMAN, NM_005688, O14517, O15440, Q29ZA9, Q29ZB1, Q86UX3, Q86W30, Q9UN85, Q9UNP5, Q9UQC3, uc317tys.1, uc317tys.2 UCSC ID: ENST00000334444.11_7 RefSeq Accession: NM_005688.4 Protein: O15440 (aka MRP5_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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