Human Gene ABHD16A (ENST00000395952.8_7) from GENCODE V47lift37
  Description: abhydrolase domain containing 16A, phospholipase, transcript variant 1 (from RefSeq NM_021160.3)
Gencode Transcript: ENST00000395952.8_7
Gencode Gene: ENSG00000204427.12_10
Transcript (Including UTRs)
   Position: hg19 chr6:31,654,732-31,671,101 Size: 16,370 Total Exon Count: 20 Strand: -
Coding Region
   Position: hg19 chr6:31,654,989-31,671,058 Size: 16,070 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:31,654,732-31,671,101)mRNA (may differ from genome)Protein (558 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ABHGA_HUMAN
DESCRIPTION: RecName: Full=Abhydrolase domain-containing protein 16A; EC=3.-.-.-; AltName: Full=HLA-B-associated transcript 5; AltName: Full=Protein G5;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the AB hydrolase superfamily. ABHD16 family.
SEQUENCE CAUTION: Sequence=CAI17808.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAI18401.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAM26084.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAM45793.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ABHD16A
Diseases sorted by gene-association score: coronary artery aneurysm (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.25 RPKM in Testis
Total median expression: 202.08 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.5043-0.547 Picture PostScript Text
3' UTR -65.60257-0.255 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026604 - ABHD16

Pfam Domains:
PF00561 - alpha/beta hydrolase fold

SCOP Domains:
53474 - alpha/beta-Hydrolases

ModBase Predicted Comparative 3D Structure on O95870
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0047372 acylglycerol lipase activity
GO:0004622 lysophospholipase activity

Biological Process:
GO:0052651 monoacylglycerol catabolic process
GO:1905344 prostaglandin catabolic process

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AF193047 - Homo sapiens PP199 mRNA, complete cds.
BC031839 - Homo sapiens HLA-B associated transcript 5, mRNA (cDNA clone MGC:24847 IMAGE:4931559), complete cds.
AK055255 - Homo sapiens cDNA FLJ30693 fis, clone FCBBF2000685, highly similar to HLA-B-associated transcript 5.
AK023194 - Homo sapiens cDNA FLJ13132 fis, clone NT2RP3003008.
AK025398 - Homo sapiens cDNA: FLJ21745 fis, clone COLF5038.
AK001207 - Homo sapiens cDNA FLJ10345 fis, clone NT2RM2000984.
AK289469 - Homo sapiens cDNA FLJ77631 complete cds, highly similar to Homo sapiens HLA-B associated transcript 5 (BAT5), mRNA.
AK297235 - Homo sapiens cDNA FLJ50806 complete cds, highly similar to HLA-B-associated transcript 5.
JD289963 - Sequence 270987 from Patent EP1572962.
JD452456 - Sequence 433480 from Patent EP1572962.
JD234434 - Sequence 215458 from Patent EP1572962.
JD328853 - Sequence 309877 from Patent EP1572962.
JD063360 - Sequence 44384 from Patent EP1572962.
JD436057 - Sequence 417081 from Patent EP1572962.
JD023521 - Sequence 4545 from Patent EP1572962.
JD034204 - Sequence 15228 from Patent EP1572962.
AK297712 - Homo sapiens cDNA FLJ53140 complete cds, highly similar to HLA-B-associated transcript 5.
JD382804 - Sequence 363828 from Patent EP1572962.
DQ891325 - Synthetic construct clone IMAGE:100003955; FLH171100.01X; RZPDo839F01100D HLA-B associated transcript 5 (BAT5) gene, encodes complete protein.
KJ897794 - Synthetic construct Homo sapiens clone ccsbBroadEn_07188 ABHD16A gene, encodes complete protein.
DQ894509 - Synthetic construct Homo sapiens clone IMAGE:100008969; FLH171096.01L; RZPDo839F0199D HLA-B associated transcript 5 (BAT5) gene, encodes complete protein.
AB529165 - Synthetic construct DNA, clone: pF1KE1036, Homo sapiens BAT5 gene for HLA-B associated transcript 5, without stop codon, in Flexi system.
AK308573 - Homo sapiens cDNA, FLJ98614.
CU689246 - Synthetic construct Homo sapiens gateway clone IMAGE:100019865 5' read BAT5 mRNA.
AK303496 - Homo sapiens cDNA FLJ54975 complete cds.
JD459133 - Sequence 440157 from Patent EP1572962.
JD391666 - Sequence 372690 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A2BEY3, ABHD16A , ABHGA_HUMAN, B7Z4R6, BAT5 , ENST00000395952.1, ENST00000395952.2, ENST00000395952.3, ENST00000395952.4, ENST00000395952.5, ENST00000395952.6, ENST00000395952.7, G5, NG26, NM_021160, O95870, PP199, Q5SRR1, Q5SRR2, Q8WYH0, Q9NW33, uc318xwh.1, uc318xwh.2
UCSC ID: ENST00000395952.8_7
RefSeq Accession: NM_021160.3
Protein: O95870 (aka ABHGA_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.