Human Gene ABT1 (ENST00000274849.3_4) from GENCODE V47lift37
  Description: activator of basal transcription 1 (from RefSeq NM_013375.4)
Gencode Transcript: ENST00000274849.3_4
Gencode Gene: ENSG00000146109.5_7
Transcript (Including UTRs)
   Position: hg19 chr6:26,597,181-26,600,967 Size: 3,787 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr6:26,597,211-26,598,873 Size: 1,663 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:26,597,181-26,600,967)mRNA (may differ from genome)Protein (272 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ABT1_HUMAN
DESCRIPTION: RecName: Full=Activator of basal transcription 1; Short=hABT1; AltName: Full=Basal transcriptional activator;
FUNCTION: Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity).
SUBUNIT: Interacts with ESF1/ABTAP (By similarity). Interacts with IGHMBP2.
SUBCELLULAR LOCATION: Nucleus (By similarity). Nucleus, nucleolus (By similarity).
SIMILARITY: Belongs to the ESF2/ABP1 family.
SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ABT1
Diseases sorted by gene-association score: neuronal intranuclear inclusion disease (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.46 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 458.79 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.6030-0.187 Picture PostScript Text
3' UTR -576.802094-0.275 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012677 - Nucleotide-bd_a/b_plait

SCOP Domains:
54928 - RNA-binding domain, RBD

ModBase Predicted Comparative 3D Structure on Q9ULW3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0005515 protein binding

Biological Process:
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0021522 spinal cord motor neuron differentiation
GO:0034462 small-subunit processome assembly

Cellular Component:
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  LF384908 - JP 2014500723-A/192411: Polycomb-Associated Non-Coding RNAs.
BC066313 - Homo sapiens activator of basal transcription 1, mRNA (cDNA clone MGC:87175 IMAGE:5272771), complete cds.
AB027258 - Homo sapiens mRNA for basal transcriptional activator hABT1, complete cds.
CU690582 - Synthetic construct Homo sapiens gateway clone IMAGE:100021279 5' read ABT1 mRNA.
AB463399 - Synthetic construct DNA, clone: pF1KB8209, Homo sapiens ABT1 gene for activator of basal transcription 1, without stop codon, in Flexi system.
CU688138 - Synthetic construct Homo sapiens gateway clone IMAGE:100021109 5' read ABT1 mRNA.
KJ893698 - Synthetic construct Homo sapiens clone ccsbBroadEn_03092 ABT1 gene, encodes complete protein.
KJ898725 - Synthetic construct Homo sapiens clone ccsbBroadEn_08119 ABT1 gene, encodes complete protein.
EU446795 - Synthetic construct Homo sapiens clone IMAGE:100070322; IMAGE:100012004; FLH257212.01L activator of basal transcription 1 (ABT1) gene, encodes complete protein.
LF331304 - JP 2014500723-A/138807: Polycomb-Associated Non-Coding RNAs.
LF331303 - JP 2014500723-A/138806: Polycomb-Associated Non-Coding RNAs.
LF331302 - JP 2014500723-A/138805: Polycomb-Associated Non-Coding RNAs.
LF331301 - JP 2014500723-A/138804: Polycomb-Associated Non-Coding RNAs.
JD391244 - Sequence 372268 from Patent EP1572962.
JD401105 - Sequence 382129 from Patent EP1572962.
JD276046 - Sequence 257070 from Patent EP1572962.
LF331300 - JP 2014500723-A/138803: Polycomb-Associated Non-Coding RNAs.
JD392376 - Sequence 373400 from Patent EP1572962.
JD453815 - Sequence 434839 from Patent EP1572962.
JD528414 - Sequence 509438 from Patent EP1572962.
JD110365 - Sequence 91389 from Patent EP1572962.
JD492760 - Sequence 473784 from Patent EP1572962.
JD314632 - Sequence 295656 from Patent EP1572962.
JD354848 - Sequence 335872 from Patent EP1572962.
JD113940 - Sequence 94964 from Patent EP1572962.
JD092863 - Sequence 73887 from Patent EP1572962.
MA620485 - JP 2018138019-A/192411: Polycomb-Associated Non-Coding RNAs.
MA566881 - JP 2018138019-A/138807: Polycomb-Associated Non-Coding RNAs.
MA566880 - JP 2018138019-A/138806: Polycomb-Associated Non-Coding RNAs.
MA566879 - JP 2018138019-A/138805: Polycomb-Associated Non-Coding RNAs.
MA566878 - JP 2018138019-A/138804: Polycomb-Associated Non-Coding RNAs.
MA566877 - JP 2018138019-A/138803: Polycomb-Associated Non-Coding RNAs.
BC048812 - Homo sapiens activator of basal transcription 1, mRNA (cDNA clone MGC:51778 IMAGE:5574755), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: ABT1_HUMAN, ENST00000274849.1, ENST00000274849.2, NM_013375, Q9ULW3, uc317jgp.1, uc317jgp.2
UCSC ID: ENST00000274849.3_4
RefSeq Accession: NM_013375.4
Protein: Q9ULW3 (aka ABT1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.