ID:ACOT8_HUMAN DESCRIPTION: RecName: Full=Acyl-coenzyme A thioesterase 8; EC=3.1.2.27; AltName: Full=Acyl-CoA thioesterase 8; AltName: Full=Choloyl-coenzyme A thioesterase; AltName: Full=HIV-Nef-associated acyl-CoA thioesterase; AltName: Full=PTE-2; AltName: Full=Peroxisomal acyl-coenzyme A thioester hydrolase 1; Short=PTE-1; AltName: Full=Peroxisomal long-chain acyl-CoA thioesterase 1; AltName: Full=Thioesterase II; Short=hACTE-III; Short=hACTEIII; Short=hTE; FUNCTION: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N- acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation. CATALYTIC ACTIVITY: Choloyl-CoA + H(2)O = cholate + CoA. SUBUNIT: Interacts with HIV-1 Nef. INTERACTION: P04601:nef (xeno); NbExp=5; IntAct=EBI-1237371, EBI-6164028; SUBCELLULAR LOCATION: Peroxisome. TISSUE SPECIFICITY: Detected in a T-cell line (at protein level). Ubiquitous. INDUCTION: Regulated by peroxisome proliferator (such as Clofibrate), via the peroxisome proliferator-activated receptors (PPARs) (By similarity). SIMILARITY: Belongs to the C/M/P thioester hydrolase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14734
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006625 protein targeting to peroxisome GO:0006637 acyl-CoA metabolic process GO:0006699 bile acid biosynthetic process GO:0007031 peroxisome organization GO:0009062 fatty acid catabolic process GO:0016032 viral process GO:0016559 peroxisome fission GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase GO:0036109 alpha-linolenic acid metabolic process GO:0043649 dicarboxylic acid catabolic process GO:0045225 negative regulation of CD4 biosynthetic process
Protein O14734 (Reactome details) participates in the following event(s):
R-HSA-193385 Hydrolysis of choloyl-CoA to cholate and CoASH R-HSA-390304 acetyl-CoA + H2O => acetate + CoASH R-HSA-2066779 Conversion of DHA-CoA to docosahexaenoic acid (DHA) R-HSA-9033233 PEX5S,L binds cargo proteins containing PTS1 R-HSA-5690042 Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA R-HSA-9033236 PEX5S,L:Cargo binds PEX13:PEX14 of PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Complex) R-HSA-9033241 Peroxisomal protein import R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-389887 Beta-oxidation of pristanoyl-CoA R-HSA-2046106 alpha-linolenic acid (ALA) metabolism R-HSA-390247 Beta-oxidation of very long chain fatty acids R-HSA-392499 Metabolism of proteins R-HSA-192105 Synthesis of bile acids and bile salts R-HSA-390918 Peroxisomal lipid metabolism R-HSA-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-194068 Bile acid and bile salt metabolism R-HSA-8978868 Fatty acid metabolism R-HSA-8957322 Metabolism of steroids R-HSA-556833 Metabolism of lipids R-HSA-1430728 Metabolism
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Common Gene Haplotype Alleles 
