ID:ACSL3_HUMAN DESCRIPTION: RecName: Full=Long-chain-fatty-acid--CoA ligase 3; EC=6.2.1.3; AltName: Full=Long-chain acyl-CoA synthetase 3; Short=LACS 3; FUNCTION: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins). CATALYTIC ACTIVITY: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. COFACTOR: Magnesium (By similarity). SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity). SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95573
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001676 long-chain fatty acid metabolic process GO:0006629 lipid metabolic process GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0007420 brain development GO:0007584 response to nutrient GO:0008152 metabolic process GO:0014070 response to organic cyclic compound GO:0034379 very-low-density lipoprotein particle assembly GO:0035338 long-chain fatty-acyl-CoA biosynthetic process GO:0042998 positive regulation of Golgi to plasma membrane protein transport GO:0044539 long-chain fatty acid import GO:0051047 positive regulation of secretion GO:2001247 positive regulation of phosphatidylcholine biosynthetic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
