ID:ADAM2_HUMAN DESCRIPTION: RecName: Full=Disintegrin and metalloproteinase domain-containing protein 2; Short=ADAM 2; AltName: Full=Cancer/testis antigen 15; Short=CT15; AltName: Full=Fertilin subunit beta; AltName: Full=PH-30; Short=PH30; AltName: Full=PH30-beta; Flags: Precursor; FUNCTION: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues. DOMAIN: A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding. PTM: The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa. MISCELLANEOUS: In mammals, exists as a heterodimer composed of an alpha and beta subunits. In human, fertilin subunit alpha is a pseudogene. SIMILARITY: Contains 1 disintegrin domain. SIMILARITY: Contains 1 EGF-like domain. SIMILARITY: Contains 1 peptidase M12B domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99965
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
