ID:ATS16_HUMAN DESCRIPTION: RecName: Full=A disintegrin and metalloproteinase with thrombospondin motifs 16; Short=ADAM-TS 16; Short=ADAM-TS16; Short=ADAMTS-16; EC=3.4.24.-; Flags: Precursor; COFACTOR: Binds 1 zinc ion per subunit (By similarity). SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity). TISSUE SPECIFICITY: Expressed in fetal lung and kidney and in adult prostate and ovary. DOMAIN: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix (By similarity). DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. PTM: The precursor is cleaved by a furin endopeptidase (By similarity). SIMILARITY: Contains 1 disintegrin domain. SIMILARITY: Contains 1 peptidase M12B domain. SIMILARITY: Contains 1 PLAC domain. SIMILARITY: Contains 6 TSP type-1 domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TE57
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001658 branching involved in ureteric bud morphogenesis GO:0003073 regulation of systemic arterial blood pressure GO:0006508 proteolysis GO:0048232 male gamete generation GO:1902017 regulation of cilium assembly
Cellular Component: GO:0005576 extracellular region
Descriptions from all associated GenBank mRNAs
AK127746 - Homo sapiens cDNA FLJ45846 fis, clone OCBBF2007039, highly similar to ADAMTS-16 precursor (EC 3.4.24.-). AJ315734 - Homo sapiens mRNA for metalloprotease disintegrin 16 (ADAMTS16 gene). AB462933 - Synthetic construct DNA, clone: pF1KB7299, Homo sapiens ADAMTS16 gene for ADAM metallopeptidase with thrombospondin type 1 motif, 16, without stop codon, in Flexi system. BC140297 - Synthetic construct Homo sapiens clone IMAGE:100014303, MGC:173246 ADAM metallopeptidase with thrombospondin type 1 motif, 16 (ADAMTS16) mRNA, encodes complete protein. AB095949 - Homo sapiens mRNA for KIAA2029 protein. DQ266047 - Homo sapiens ADAMTS16s alternative splice form mRNA, complete cds. AK122980 - Homo sapiens cDNA FLJ16731 fis, clone BNGH42000994, highly similar to ADAMTS-16 precursor (EC 3.4.24.-). AM983533 - Homo sapiens partial mRNA for ADAM metallopeptidase with thrombospondin type 1 motif, 16 (ADAMTS16 gene), isolated from fetal kidney.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8TE57 (Reactome details) participates in the following event(s):
R-HSA-5173192 POFUT2 transfers fucose to TSR domain-containing proteins R-HSA-5173005 B3GALTL transfers glucose to O-fucosyl-proteins R-HSA-1592310 Aggrecan degradation by ADAMTSs R-NUL-2533988 Aggrecan degradation by ADAMTS4,ADAMTS5 R-HSA-5173214 O-glycosylation of TSR domain-containing proteins R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS) R-HSA-1474228 Degradation of the extracellular matrix R-HSA-5173105 O-linked glycosylation R-HSA-3906995 Diseases associated with O-glycosylation of proteins R-HSA-1474244 Extracellular matrix organization R-HSA-597592 Post-translational protein modification R-HSA-3781865 Diseases of glycosylation R-HSA-392499 Metabolism of proteins R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
