The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60266
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF087963 - Homo sapiens full length insert cDNA clone YU49D08. BC020148 - Homo sapiens cDNA clone IMAGE:4341424, containing frame-shift errors. AK075424 - Homo sapiens cDNA PSEC0115 fis, clone PLACE1000086, highly similar to ADENYLATE CYCLASE, OLFACTIVE TYPE (EC 4.6.1.1). AK095173 - Homo sapiens cDNA FLJ37854 fis, clone BRSSN2014610, highly similar to Adenylate cyclase type 3 (EC 4.6.1.1). AB011083 - Homo sapiens mRNA for KIAA0511 protein, partial cds. AK027857 - Homo sapiens cDNA FLJ14951 fis, clone PLACE3000020, highly similar to Adenylate cyclase type 3 (EC 4.6.1.1). AK122926 - Homo sapiens cDNA FLJ16612 fis, clone TESTI4012010, highly similar to Adenylate cyclase type 3 (EC 4.6.1.1). AF033861 - Homo sapiens type III adenylyl cyclase (AC-III) mRNA, complete cds. JD344606 - Sequence 325630 from Patent EP1572962. JD162858 - Sequence 143882 from Patent EP1572962. JD076539 - Sequence 57563 from Patent EP1572962. JD162602 - Sequence 143626 from Patent EP1572962. JD202089 - Sequence 183113 from Patent EP1572962. JD445931 - Sequence 426955 from Patent EP1572962. JD552112 - Sequence 533136 from Patent EP1572962. BC126235 - Homo sapiens adenylate cyclase 3, mRNA (cDNA clone MGC:161513 IMAGE:8991951), complete cds. BC144119 - Homo sapiens adenylate cyclase 3, mRNA (cDNA clone MGC:177656 IMAGE:9052639), complete cds. JD037018 - Sequence 18042 from Patent EP1572962. JD164167 - Sequence 145191 from Patent EP1572962. JD020400 - Sequence 1424 from Patent EP1572962. JD437317 - Sequence 418341 from Patent EP1572962. KJ890630 - Synthetic construct Homo sapiens clone ccsbBroadEn_00024 ADCY3 gene, encodes complete protein. HQ258684 - Synthetic construct Homo sapiens clone IMAGE:100072714 adenylate cyclase 3 (ADCY3) gene, encodes complete protein. JD021497 - Sequence 2521 from Patent EP1572962. JD032099 - Sequence 13123 from Patent EP1572962. DQ579852 - Homo sapiens piRNA piR-47964, complete sequence. DQ571701 - Homo sapiens piRNA piR-31813, complete sequence. JD555535 - Sequence 536559 from Patent EP1572962. JD436408 - Sequence 417432 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O60266 (Reactome details) participates in the following event(s):
R-HSA-163617 G alpha (s) activates adenylate cyclase R-HSA-170672 Galpha-olf:GTP binds to adenylate cyclase and activates it R-HSA-392064 G alpha (z) inhibits adenylate cyclase R-HSA-392206 G alpha (i) inhibits adenylate cyclase R-HSA-170674 Dissociation of the Gi alpha:G olf complex R-HSA-170677 The G alpha-olf:GDP:Adenylate cyclase complex dissociates R-HSA-442715 Activation of Adenylate Cyclase R-HSA-170685 Adenylaye cyclase increases the GTPase activity of G alpha-olf R-HSA-170686 Adenylate cyclase increases the GTPase activity of Gi alpha R-HSA-170671 G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex R-HSA-111930 Adenylate cyclase produces cAMP R-HSA-392129 Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate R-HSA-5610727 GPR161 promotes cAMP production in a G alpha(s)-dependent manner R-HSA-164377 Activated Adenylate cyclase catalyses cAMP synthesis R-HSA-170676 Adenylate cyclase converts ATP into cyclic AMP R-HSA-170666 Adenylate cyclase increases the GTPase activity of G alpha-olf R-HSA-163359 Glucagon signaling in metabolic regulation R-HSA-418555 G alpha (s) signalling events R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-170660 Adenylate cyclase activating pathway R-HSA-418597 G alpha (z) signalling events R-HSA-170670 Adenylate cyclase inhibitory pathway R-HSA-418594 G alpha (i) signalling events R-HSA-442720 CREB phosphorylation through the activation of Adenylate Cyclase R-HSA-163685 Energy Metabolism R-HSA-388396 GPCR downstream signalling R-HSA-445717 Aquaporin-mediated transport R-HSA-112040 G-protein mediated events R-HSA-997269 Inhibition of adenylate cyclase pathway R-HSA-163615 PKA activation R-HSA-438064 Post NMDA receptor activation events R-HSA-5610787 Hedgehog 'off' state R-HSA-164378 PKA activation in glucagon signalling R-HSA-1430728 Metabolism R-HSA-372790 Signaling by GPCR R-HSA-382551 Transport of small molecules R-HSA-111885 Opioid Signalling R-HSA-991365 Activation of GABAB receptors R-HSA-111931 PKA-mediated phosphorylation of CREB R-HSA-442755 Activation of NMDA receptor and postsynaptic events R-HSA-5358351 Signaling by Hedgehog R-HSA-162582 Signal Transduction R-HSA-977444 GABA B receptor activation R-HSA-111933 Calmodulin induced events R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-977443 GABA receptor activation R-HSA-111997 CaM pathway R-HSA-112315 Transmission across Chemical Synapses R-HSA-111996 Ca-dependent events R-HSA-1489509 DAG and IP3 signaling R-HSA-112316 Neuronal System R-HSA-112043 PLC beta mediated events R-HSA-9006925 Intracellular signaling by second messengers
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
