The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NFM4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK122714 - Homo sapiens cDNA FLJ16206 fis, clone CTONG2019590, highly similar to Adenylate cyclase type 4 (EC 4.6.1.1). AK126468 - Homo sapiens cDNA FLJ44504 fis, clone UTERU3001240, highly similar to Adenylate cyclase, type IV (EC 4.6.1.1). AK056745 - Homo sapiens cDNA FLJ32183 fis, clone PLACE6001886, highly similar to ADENYLATE CYCLASE, TYPE IV (EC 4.6.1.1). AF086230 - Homo sapiens full length insert cDNA clone ZD17A07. AF088070 - Homo sapiens full length insert cDNA clone ZD90F02. BC015982 - Homo sapiens adenylate cyclase 4, mRNA (cDNA clone IMAGE:4070784), partial cds. BX537489 - Homo sapiens mRNA; cDNA DKFZp686G1462 (from clone DKFZp686G1462). AK131333 - Homo sapiens cDNA FLJ16344 fis, clone TESTI2032643, moderately similar to ADENYLATE CYCLASE, TYPE IV (EC 4.6.1.1). AF497516 - Homo sapiens adenylate cyclase type IV (ADCY4) mRNA, complete cds. BC117473 - Homo sapiens adenylate cyclase 4, mRNA (cDNA clone MGC:151082 IMAGE:40126024), complete cds. BC143947 - Homo sapiens cDNA clone IMAGE:9052465. BX248285 - human full-length cDNA clone CS0DI063YK23 of Placenta of Homo sapiens (human). JD337169 - Sequence 318193 from Patent EP1572962. BC117475 - Homo sapiens adenylate cyclase 4, mRNA (cDNA clone MGC:151084 IMAGE:40126026), complete cds. JD539324 - Sequence 520348 from Patent EP1572962. JD026348 - Sequence 7372 from Patent EP1572962. JD029254 - Sequence 10278 from Patent EP1572962. BC027943 - Homo sapiens adenylate cyclase 4, mRNA (cDNA clone IMAGE:5204105), with apparent retained intron.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8NFM4 (Reactome details) participates in the following event(s):
R-HSA-163617 G alpha (s) activates adenylate cyclase R-HSA-170672 Galpha-olf:GTP binds to adenylate cyclase and activates it R-HSA-392064 G alpha (z) inhibits adenylate cyclase R-HSA-392206 G alpha (i) inhibits adenylate cyclase R-HSA-170674 Dissociation of the Gi alpha:G olf complex R-HSA-170677 The G alpha-olf:GDP:Adenylate cyclase complex dissociates R-HSA-170685 Adenylaye cyclase increases the GTPase activity of G alpha-olf R-HSA-170686 Adenylate cyclase increases the GTPase activity of Gi alpha R-HSA-170671 G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex R-HSA-111930 Adenylate cyclase produces cAMP R-HSA-392129 Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate R-HSA-5610727 GPR161 promotes cAMP production in a G alpha(s)-dependent manner R-HSA-164377 Activated Adenylate cyclase catalyses cAMP synthesis R-HSA-170676 Adenylate cyclase converts ATP into cyclic AMP R-HSA-170666 Adenylate cyclase increases the GTPase activity of G alpha-olf R-HSA-163359 Glucagon signaling in metabolic regulation R-HSA-418555 G alpha (s) signalling events R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-170660 Adenylate cyclase activating pathway R-HSA-418597 G alpha (z) signalling events R-HSA-170670 Adenylate cyclase inhibitory pathway R-HSA-418594 G alpha (i) signalling events R-HSA-163685 Energy Metabolism R-HSA-388396 GPCR downstream signalling R-HSA-445717 Aquaporin-mediated transport R-HSA-112040 G-protein mediated events R-HSA-997269 Inhibition of adenylate cyclase pathway R-HSA-163615 PKA activation R-HSA-5610787 Hedgehog 'off' state R-HSA-164378 PKA activation in glucagon signalling R-HSA-1430728 Metabolism R-HSA-372790 Signaling by GPCR R-HSA-382551 Transport of small molecules R-HSA-111885 Opioid Signalling R-HSA-991365 Activation of GABAB receptors R-HSA-111931 PKA-mediated phosphorylation of CREB R-HSA-5358351 Signaling by Hedgehog R-HSA-162582 Signal Transduction R-HSA-977444 GABA B receptor activation R-HSA-111933 Calmodulin induced events R-HSA-977443 GABA receptor activation R-HSA-111997 CaM pathway R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-111996 Ca-dependent events R-HSA-1489509 DAG and IP3 signaling R-HSA-112315 Transmission across Chemical Synapses R-HSA-112043 PLC beta mediated events R-HSA-9006925 Intracellular signaling by second messengers R-HSA-112316 Neuronal System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
