The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43306
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BX537664 - Homo sapiens mRNA; cDNA DKFZp779F075 (from clone DKFZp779F075). BC064923 - Homo sapiens adenylate cyclase 6, mRNA (cDNA clone IMAGE:6141275). AB007882 - Homo sapiens KIAA0422 mRNA. JD206095 - Sequence 187119 from Patent EP1572962. JD065666 - Sequence 46690 from Patent EP1572962. JD054148 - Sequence 35172 from Patent EP1572962. AF250226 - Homo sapiens adenylyl cyclase type VI mRNA, complete cds. JD223070 - Sequence 204094 from Patent EP1572962. JD369194 - Sequence 350218 from Patent EP1572962. JD182743 - Sequence 163767 from Patent EP1572962. JD219339 - Sequence 200363 from Patent EP1572962. JD329997 - Sequence 311021 from Patent EP1572962. JD328171 - Sequence 309195 from Patent EP1572962. JD460279 - Sequence 441303 from Patent EP1572962. JD453996 - Sequence 435020 from Patent EP1572962. JD559837 - Sequence 540861 from Patent EP1572962. JD548620 - Sequence 529644 from Patent EP1572962. JD166859 - Sequence 147883 from Patent EP1572962. JD054968 - Sequence 35992 from Patent EP1572962. JD299402 - Sequence 280426 from Patent EP1572962. JD182019 - Sequence 163043 from Patent EP1572962. JD119439 - Sequence 100463 from Patent EP1572962. JD124041 - Sequence 105065 from Patent EP1572962. JD233264 - Sequence 214288 from Patent EP1572962. JD442216 - Sequence 423240 from Patent EP1572962. JD384836 - Sequence 365860 from Patent EP1572962. JD255296 - Sequence 236320 from Patent EP1572962. JD566334 - Sequence 547358 from Patent EP1572962. JD157464 - Sequence 138488 from Patent EP1572962. JD483562 - Sequence 464586 from Patent EP1572962. JD182798 - Sequence 163822 from Patent EP1572962. JD142193 - Sequence 123217 from Patent EP1572962. JD076968 - Sequence 57992 from Patent EP1572962. JD515510 - Sequence 496534 from Patent EP1572962. JD551856 - Sequence 532880 from Patent EP1572962. JD438181 - Sequence 419205 from Patent EP1572962. JD178461 - Sequence 159485 from Patent EP1572962. JD368754 - Sequence 349778 from Patent EP1572962. JD089020 - Sequence 70044 from Patent EP1572962. JD115795 - Sequence 96819 from Patent EP1572962. JD195690 - Sequence 176714 from Patent EP1572962. JD431743 - Sequence 412767 from Patent EP1572962. JD263215 - Sequence 244239 from Patent EP1572962. JD431590 - Sequence 412614 from Patent EP1572962. JD225104 - Sequence 206128 from Patent EP1572962. JD215837 - Sequence 196861 from Patent EP1572962. JD251151 - Sequence 232175 from Patent EP1572962. JD549791 - Sequence 530815 from Patent EP1572962. JD357265 - Sequence 338289 from Patent EP1572962. JD202535 - Sequence 183559 from Patent EP1572962. JD257565 - Sequence 238589 from Patent EP1572962. JD114586 - Sequence 95610 from Patent EP1572962. JD532435 - Sequence 513459 from Patent EP1572962. JD069653 - Sequence 50677 from Patent EP1572962. JD485468 - Sequence 466492 from Patent EP1572962. JD060797 - Sequence 41821 from Patent EP1572962. JD231042 - Sequence 212066 from Patent EP1572962. JD282315 - Sequence 263339 from Patent EP1572962. JD091883 - Sequence 72907 from Patent EP1572962. AB383879 - Synthetic construct DNA, clone: pF1KSDA0422, Homo sapiens ADCY6 gene for adenylate cyclase type 6, complete cds, without stop codon, in Flexi system. AK294446 - Homo sapiens cDNA FLJ57105 complete cds, highly similar to Adenylate cyclase type 6 (EC 4.6.1.1). U65474 - Homo sapiens adenylyl cyclase type VI mRNA, partial cds. AK225224 - Homo sapiens mRNA for adenylate cyclase 6 isoform b variant, clone: COL06070. JD195847 - Sequence 176871 from Patent EP1572962. LQ980384 - Sequence 30 from Patent WO2013050532.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O43306 (Reactome details) participates in the following event(s):
R-HSA-400097 G-beta:G-gamma inhibits Adenylate cyclase R-HSA-381704 G(s):GTP activates Adenylyl cyclase R-HSA-163617 G alpha (s) activates adenylate cyclase R-HSA-170672 Galpha-olf:GTP binds to adenylate cyclase and activates it R-HSA-392064 G alpha (z) inhibits adenylate cyclase R-HSA-392206 G alpha (i) inhibits adenylate cyclase R-HSA-170674 Dissociation of the Gi alpha:G olf complex R-HSA-170677 The G alpha-olf:GDP:Adenylate cyclase complex dissociates R-HSA-170685 Adenylaye cyclase increases the GTPase activity of G alpha-olf R-HSA-170686 Adenylate cyclase increases the GTPase activity of Gi alpha R-HSA-170671 G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex R-HSA-111930 Adenylate cyclase produces cAMP R-HSA-392129 Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate R-HSA-381607 Activated Adenylyl cyclase synthesizes cyclic AMP R-HSA-5610727 GPR161 promotes cAMP production in a G alpha(s)-dependent manner R-HSA-164377 Activated Adenylate cyclase catalyses cAMP synthesis R-HSA-170676 Adenylate cyclase converts ATP into cyclic AMP R-HSA-170666 Adenylate cyclase increases the GTPase activity of G alpha-olf R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion R-HSA-163359 Glucagon signaling in metabolic regulation R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-418555 G alpha (s) signalling events R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-170660 Adenylate cyclase activating pathway R-HSA-418597 G alpha (z) signalling events R-HSA-170670 Adenylate cyclase inhibitory pathway R-HSA-418594 G alpha (i) signalling events R-HSA-422356 Regulation of insulin secretion R-HSA-163685 Energy Metabolism R-HSA-388396 GPCR downstream signalling R-HSA-445717 Aquaporin-mediated transport R-HSA-112040 G-protein mediated events R-HSA-997269 Inhibition of adenylate cyclase pathway R-HSA-163615 PKA activation R-HSA-1430728 Metabolism R-HSA-5610787 Hedgehog 'off' state R-HSA-164378 PKA activation in glucagon signalling R-HSA-372790 Signaling by GPCR R-HSA-382551 Transport of small molecules R-HSA-111885 Opioid Signalling R-HSA-991365 Activation of GABAB receptors R-HSA-111931 PKA-mediated phosphorylation of CREB R-HSA-5358351 Signaling by Hedgehog R-HSA-162582 Signal Transduction R-HSA-977444 GABA B receptor activation R-HSA-111933 Calmodulin induced events R-HSA-977443 GABA receptor activation R-HSA-111997 CaM pathway R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-111996 Ca-dependent events R-HSA-1489509 DAG and IP3 signaling R-HSA-112315 Transmission across Chemical Synapses R-HSA-112043 PLC beta mediated events R-HSA-9006925 Intracellular signaling by second messengers R-HSA-112316 Neuronal System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
