Human Gene ADCY7 (ENST00000673801.1_3) from GENCODE V47lift37
  Description: adenylate cyclase 7, transcript variant 1 (from RefSeq NM_001114.5)
Gencode Transcript: ENST00000673801.1_3
Gencode Gene: ENSG00000121281.13_15
Transcript (Including UTRs)
   Position: hg19 chr16:50,300,462-50,352,046 Size: 51,585 Total Exon Count: 26 Strand: +
Coding Region
   Position: hg19 chr16:50,322,091-50,349,416 Size: 27,326 Coding Exon Count: 25 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:50,300,462-50,352,046)mRNA (may differ from genome)Protein (1080 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ADCY7_HUMAN
DESCRIPTION: RecName: Full=Adenylate cyclase type 7; EC=4.6.1.1; AltName: Full=ATP pyrophosphate-lyase 7; AltName: Full=Adenylate cyclase type VII; AltName: Full=Adenylyl cyclase 7;
FUNCTION: This is a membrane-bound, calcium-inhibitable adenylyl cyclase.
CATALYTIC ACTIVITY: ATP = 3',5'-cyclic AMP + diphosphate.
COFACTOR: Binds 2 magnesium ions per subunit (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
SIMILARITY: Contains 2 guanylate cyclase domains.
SEQUENCE CAUTION: Sequence=BAA05021.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D001564 Benzo(a)pyrene
  • D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
  • C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
  • D015124 8-Bromo Cyclic Adenosine Monophosphate
  • D015766 Albendazole
  • D002110 Caffeine
  • D002220 Carbamazepine
  • D002251 Carbon Tetrachloride
  • D002737 Chloroprene
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -195.60398-0.491 Picture PostScript Text
3' UTR -804.402630-0.306 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001054 - A/G_cyclase
IPR018297 - A/G_cyclase_CS
IPR009398 - Adenylate_cyclase-like

Pfam Domains:
PF00211 - Adenylate and Guanylate cyclase catalytic domain
PF06327 - Domain of Unknown Function (DUF1053)
PF16214 - Adenylyl cyclase N-terminal extracellular and transmembrane region

SCOP Domains:
55073 - Nucleotide cyclase

ModBase Predicted Comparative 3D Structure on P51828
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004016 adenylate cyclase activity
GO:0004383 guanylate cyclase activity
GO:0005524 ATP binding
GO:0016829 lyase activity
GO:0016849 phosphorus-oxygen lyase activity
GO:0046872 metal ion binding

Biological Process:
GO:0003091 renal water homeostasis
GO:0006171 cAMP biosynthetic process
GO:0006182 cGMP biosynthetic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction
GO:0060135 maternal process involved in female pregnancy
GO:0071361 cellular response to ethanol
GO:0071377 cellular response to glucagon stimulus

Cellular Component:
GO:0005886 plasma membrane
GO:0008074 guanylate cyclase complex, soluble
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK093706 - Homo sapiens cDNA FLJ36387 fis, clone THYMU2008799, highly similar to Adenylate cyclase type 7 (EC 4.6.1.1).
BC028085 - Homo sapiens cDNA clone IMAGE:5218193, **** WARNING: chimeric clone ****.
BC039891 - Homo sapiens adenylate cyclase 7, mRNA (cDNA clone IMAGE:5211601), complete cds.
D25538 - Homo sapiens KIAA0037 mRNA.
BC098566 - Homo sapiens cDNA clone IMAGE:30924798, containing frame-shift errors.
BC126271 - Homo sapiens adenylate cyclase 7, mRNA (cDNA clone MGC:161549 IMAGE:8991987), complete cds.
BC144120 - Homo sapiens cDNA clone IMAGE:9052640, containing frame-shift errors.
AB383721 - Synthetic construct DNA, clone: pF1KSDA0037, Homo sapiens ADCY7 gene for adenylate cyclase type 7, complete cds, without stop codon, in Flexi system.
JD492525 - Sequence 473549 from Patent EP1572962.
JD492526 - Sequence 473550 from Patent EP1572962.
JD373213 - Sequence 354237 from Patent EP1572962.
JD373214 - Sequence 354238 from Patent EP1572962.
JD266832 - Sequence 247856 from Patent EP1572962.
JD391404 - Sequence 372428 from Patent EP1572962.
JD119591 - Sequence 100615 from Patent EP1572962.
JD209938 - Sequence 190962 from Patent EP1572962.
JD525427 - Sequence 506451 from Patent EP1572962.
JD193931 - Sequence 174955 from Patent EP1572962.
JD368858 - Sequence 349882 from Patent EP1572962.
DL492459 - Novel nucleic acids.
DL490936 - Novel nucleic acids.
JD081765 - Sequence 62789 from Patent EP1572962.
JD067269 - Sequence 48293 from Patent EP1572962.
JD436184 - Sequence 417208 from Patent EP1572962.
JD057094 - Sequence 38118 from Patent EP1572962.
JD120478 - Sequence 101502 from Patent EP1572962.
JD234657 - Sequence 215681 from Patent EP1572962.
JD185648 - Sequence 166672 from Patent EP1572962.
JD178837 - Sequence 159861 from Patent EP1572962.
JD522120 - Sequence 503144 from Patent EP1572962.
JD282194 - Sequence 263218 from Patent EP1572962.
JD558563 - Sequence 539587 from Patent EP1572962.
JD057634 - Sequence 38658 from Patent EP1572962.
JD153920 - Sequence 134944 from Patent EP1572962.
JD340036 - Sequence 321060 from Patent EP1572962.
JD484212 - Sequence 465236 from Patent EP1572962.
JD462578 - Sequence 443602 from Patent EP1572962.
JD565180 - Sequence 546204 from Patent EP1572962.
JD300391 - Sequence 281415 from Patent EP1572962.
JD049208 - Sequence 30232 from Patent EP1572962.
JD184621 - Sequence 165645 from Patent EP1572962.
JD302211 - Sequence 283235 from Patent EP1572962.
JD232791 - Sequence 213815 from Patent EP1572962.
JD548530 - Sequence 529554 from Patent EP1572962.
JD534715 - Sequence 515739 from Patent EP1572962.
JD535239 - Sequence 516263 from Patent EP1572962.
JD409036 - Sequence 390060 from Patent EP1572962.
JD307353 - Sequence 288377 from Patent EP1572962.
JD469693 - Sequence 450717 from Patent EP1572962.
JD067060 - Sequence 48084 from Patent EP1572962.
JD301469 - Sequence 282493 from Patent EP1572962.
JD306215 - Sequence 287239 from Patent EP1572962.
JD447757 - Sequence 428781 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P51828 (Reactome details) participates in the following event(s):

R-HSA-163617 G alpha (s) activates adenylate cyclase
R-HSA-170672 Galpha-olf:GTP binds to adenylate cyclase and activates it
R-HSA-392064 G alpha (z) inhibits adenylate cyclase
R-HSA-392206 G alpha (i) inhibits adenylate cyclase
R-HSA-170674 Dissociation of the Gi alpha:G olf complex
R-HSA-170677 The G alpha-olf:GDP:Adenylate cyclase complex dissociates
R-HSA-170685 Adenylaye cyclase increases the GTPase activity of G alpha-olf
R-HSA-170686 Adenylate cyclase increases the GTPase activity of Gi alpha
R-HSA-170671 G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex
R-HSA-111930 Adenylate cyclase produces cAMP
R-HSA-392129 Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
R-HSA-5610727 GPR161 promotes cAMP production in a G alpha(s)-dependent manner
R-HSA-164377 Activated Adenylate cyclase catalyses cAMP synthesis
R-HSA-170676 Adenylate cyclase converts ATP into cyclic AMP
R-HSA-170666 Adenylate cyclase increases the GTPase activity of G alpha-olf
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-418555 G alpha (s) signalling events
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-170660 Adenylate cyclase activating pathway
R-HSA-418597 G alpha (z) signalling events
R-HSA-170670 Adenylate cyclase inhibitory pathway
R-HSA-418594 G alpha (i) signalling events
R-HSA-163685 Energy Metabolism
R-HSA-388396 GPCR downstream signalling
R-HSA-445717 Aquaporin-mediated transport
R-HSA-112040 G-protein mediated events
R-HSA-997269 Inhibition of adenylate cyclase pathway
R-HSA-163615 PKA activation
R-HSA-5610787 Hedgehog 'off' state
R-HSA-164378 PKA activation in glucagon signalling
R-HSA-1430728 Metabolism
R-HSA-372790 Signaling by GPCR
R-HSA-382551 Transport of small molecules
R-HSA-111885 Opioid Signalling
R-HSA-991365 Activation of GABAB receptors
R-HSA-111931 PKA-mediated phosphorylation of CREB
R-HSA-5358351 Signaling by Hedgehog
R-HSA-162582 Signal Transduction
R-HSA-977444 GABA B receptor activation
R-HSA-111933 Calmodulin induced events
R-HSA-977443 GABA receptor activation
R-HSA-111997 CaM pathway
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-111996 Ca-dependent events
R-HSA-1489509 DAG and IP3 signaling
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112043 PLC beta mediated events
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-112316 Neuronal System

-  Other Names for This Gene
  Alternate Gene Symbols: A0AVA6, ADCY7 , ADCY7_HUMAN, KIAA0037 , NM_001114, P51828, uc329xjs.1, uc329xjs.2
UCSC ID: ENST00000673801.1_3
RefSeq Accession: NM_001114.5
Protein: P51828 (aka ADCY7_HUMAN or CYA7_HUMAN)

-  Gene Model Information
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-  Methods, Credits, and Use Restrictions
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