ID:ADCY9_HUMAN DESCRIPTION: RecName: Full=Adenylate cyclase type 9; EC=4.6.1.1; AltName: Full=ATP pyrophosphate-lyase 9; AltName: Full=Adenylate cyclase type IX; AltName: Full=Adenylyl cyclase 9; FUNCTION: May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity). CATALYTIC ACTIVITY: ATP = 3',5'-cyclic AMP + diphosphate. COFACTOR: Binds 2 magnesium ions per subunit. ENZYME REGULATION: Insensitive to calcium/calmodulin, forskolin and somatostatin. Stimulated by beta-adrenergic receptor activation. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in multiple cells of the lung, with expression highest in airway smooth muscle. SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. SIMILARITY: Contains 2 guanylate cyclase domains. SEQUENCE CAUTION: Sequence=AAC24201.1; Type=Frameshift; Positions=1252; Sequence=BAA25446.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60503
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC151229 - Homo sapiens adenylate cyclase 9, mRNA (cDNA clone MGC:166903 IMAGE:9007273), complete cds. AB011092 - Homo sapiens KIAA0520 mRNA for KIAA0520 protein. BC136657 - Homo sapiens adenylate cyclase 9, mRNA (cDNA clone MGC:168270 IMAGE:9020647), complete cds. BC136658 - Homo sapiens adenylate cyclase 9, mRNA (cDNA clone MGC:168271 IMAGE:9020648), complete cds. AF036927 - Homo sapiens adenylyl cyclase type IX mRNA, complete cds. AJ133123 - Homo sapiens mRNA for adenylyl cyclase type IX. BC151207 - Homo sapiens adenylate cyclase 9, mRNA (cDNA clone MGC:164747 IMAGE:40147127), complete cds. DQ005545 - Homo sapiens adenylyl cyclase type 9 (ADCY9) mRNA, complete cds. DQ008441 - Homo sapiens adenylyl cyclase type 9 mRNA, complete cds. KJ896379 - Synthetic construct Homo sapiens clone ccsbBroadEn_05773 ADCY9 gene, encodes complete protein. KR711973 - Synthetic construct Homo sapiens clone CCSBHm_00033288 ADCY9 (ADCY9) mRNA, encodes complete protein. AB384489 - Synthetic construct DNA, clone: pF1KA0520, Homo sapiens ADCY9 gene for adenylate cyclase type 9, complete cds, without stop codon, in Flexi system. BC068612 - Homo sapiens cDNA clone IMAGE:30331160. JD443480 - Sequence 424504 from Patent EP1572962. JD047846 - Sequence 28870 from Patent EP1572962. JD378318 - Sequence 359342 from Patent EP1572962. JD363797 - Sequence 344821 from Patent EP1572962. JD067478 - Sequence 48502 from Patent EP1572962. JD236977 - Sequence 218001 from Patent EP1572962. JD089764 - Sequence 70788 from Patent EP1572962. JD172965 - Sequence 153989 from Patent EP1572962. JD143158 - Sequence 124182 from Patent EP1572962. JB025513 - Sequence 61 from Patent EP2505645. JD162989 - Sequence 144013 from Patent EP1572962. JD409745 - Sequence 390769 from Patent EP1572962. JD120096 - Sequence 101120 from Patent EP1572962. JD493111 - Sequence 474135 from Patent EP1572962. JD438577 - Sequence 419601 from Patent EP1572962. AK022108 - Homo sapiens cDNA FLJ12046 fis, clone HEMBB1001962. DQ584147 - Homo sapiens piRNA piR-51259, complete sequence.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O60503 (Reactome details) participates in the following event(s):
R-HSA-163617 G alpha (s) activates adenylate cyclase R-HSA-170672 Galpha-olf:GTP binds to adenylate cyclase and activates it R-HSA-392064 G alpha (z) inhibits adenylate cyclase R-HSA-392206 G alpha (i) inhibits adenylate cyclase R-HSA-170674 Dissociation of the Gi alpha:G olf complex R-HSA-170677 The G alpha-olf:GDP:Adenylate cyclase complex dissociates R-HSA-170685 Adenylaye cyclase increases the GTPase activity of G alpha-olf R-HSA-170686 Adenylate cyclase increases the GTPase activity of Gi alpha R-HSA-170671 G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex R-HSA-111930 Adenylate cyclase produces cAMP R-HSA-392129 Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate R-HSA-5610727 GPR161 promotes cAMP production in a G alpha(s)-dependent manner R-HSA-164377 Activated Adenylate cyclase catalyses cAMP synthesis R-HSA-170676 Adenylate cyclase converts ATP into cyclic AMP R-HSA-170666 Adenylate cyclase increases the GTPase activity of G alpha-olf R-HSA-163359 Glucagon signaling in metabolic regulation R-HSA-418555 G alpha (s) signalling events R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-170660 Adenylate cyclase activating pathway R-HSA-418597 G alpha (z) signalling events R-HSA-170670 Adenylate cyclase inhibitory pathway R-HSA-418594 G alpha (i) signalling events R-HSA-163685 Energy Metabolism R-HSA-388396 GPCR downstream signalling R-HSA-445717 Aquaporin-mediated transport R-HSA-112040 G-protein mediated events R-HSA-997269 Inhibition of adenylate cyclase pathway R-HSA-163615 PKA activation R-HSA-5610787 Hedgehog 'off' state R-HSA-164378 PKA activation in glucagon signalling R-HSA-1430728 Metabolism R-HSA-372790 Signaling by GPCR R-HSA-382551 Transport of small molecules R-HSA-111885 Opioid Signalling R-HSA-991365 Activation of GABAB receptors R-HSA-111931 PKA-mediated phosphorylation of CREB R-HSA-5358351 Signaling by Hedgehog R-HSA-162582 Signal Transduction R-HSA-977444 GABA B receptor activation R-HSA-111933 Calmodulin induced events R-HSA-977443 GABA receptor activation R-HSA-111997 CaM pathway R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-111996 Ca-dependent events R-HSA-1489509 DAG and IP3 signaling R-HSA-112315 Transmission across Chemical Synapses R-HSA-112043 PLC beta mediated events R-HSA-9006925 Intracellular signaling by second messengers R-HSA-112316 Neuronal System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
