Human Gene ADCYAP1 (ENST00000450565.8_4) from GENCODE V47lift37
  Description: adenylate cyclase activating polypeptide 1, transcript variant 1 (from RefSeq NM_001099733.2)
Gencode Transcript: ENST00000450565.8_4
Gencode Gene: ENSG00000141433.13_7
Transcript (Including UTRs)
   Position: hg19 chr18:904,872-912,173 Size: 7,302 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr18:905,388-909,636 Size: 4,249 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:904,872-912,173)mRNA (may differ from genome)Protein (176 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PACA_HUMAN
DESCRIPTION: RecName: Full=Pituitary adenylate cyclase-activating polypeptide; Short=PACAP; Contains: RecName: Full=PACAP-related peptide; AltName: Full=PRP-48; Contains: RecName: Full=Pituitary adenylate cyclase-activating polypeptide 27; Short=PACAP-27; Short=PACAP27; Contains: RecName: Full=Pituitary adenylate cyclase-activating polypeptide 38; Short=PACAP-38; Short=PACAP38; Flags: Precursor;
FUNCTION: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells.
SUBUNIT: Interacts with ADCYAP1R1 (via N-terminal extracellular domain).
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the glucagon family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ADCYAP1
Diseases sorted by gene-association score: persian gulf syndrome (18), sudden infant death syndrome (12), holoprosencephaly 3 (11), post-traumatic stress disorder (7), pheochromocytoma (2), migraine with or without aura 1 (2), parkinson disease, late-onset (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D019256 Cadmium Chloride
  • D020889 Rolipram
  • C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester
  • D015056 1-Methyl-3-isobutylxanthine
  • D015655 1-Methyl-4-phenylpyridinium
  • D019796 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
  • C095284 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • D000082 Acetaminophen
  • D000143 Acids
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.75 RPKM in Brain - Hypothalamus
Total median expression: 43.14 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -81.20191-0.425 Picture PostScript Text
3' UTR -666.402537-0.263 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000532 - Glucagon_GIP_secretin_VIP

Pfam Domains:
PF00123 - Peptide hormone

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1GEA - NMR 2D2P - NMR MuPIT 2JOD - NMR MuPIT


ModBase Predicted Comparative 3D Structure on P18509
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005057 signal transducer activity, downstream of receptor
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding
GO:0016521 pituitary adenylate cyclase activating polypeptide activity
GO:0031858 pituitary adenylate cyclase-activating polypeptide receptor binding
GO:0051428 peptide hormone receptor binding

Biological Process:
GO:0001541 ovarian follicle development
GO:0001662 behavioral fear response
GO:0001821 histamine secretion
GO:0001932 regulation of protein phosphorylation
GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus
GO:0002878 negative regulation of acute inflammatory response to non-antigenic stimulus
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0007267 cell-cell signaling
GO:0007399 nervous system development
GO:0007565 female pregnancy
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0010469 regulation of receptor activity
GO:0010628 positive regulation of gene expression
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0010976 positive regulation of neuron projection development
GO:0019233 sensory perception of pain
GO:0019933 cAMP-mediated signaling
GO:0021983 pituitary gland development
GO:0030073 insulin secretion
GO:0031175 neuron projection development
GO:0032755 positive regulation of interleukin-6 production
GO:0032880 regulation of protein localization
GO:0034260 negative regulation of GTPase activity
GO:0042594 response to starvation
GO:0043267 negative regulation of potassium ion transport
GO:0043547 positive regulation of GTPase activity
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045471 response to ethanol
GO:0045786 negative regulation of cell cycle
GO:0045860 positive regulation of protein kinase activity
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046034 ATP metabolic process
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060078 regulation of postsynaptic membrane potential
GO:0060124 positive regulation of growth hormone secretion
GO:0060253 negative regulation of glial cell proliferation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070445 regulation of oligodendrocyte progenitor proliferation
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production
GO:0090274 positive regulation of somatostatin secretion

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0043195 terminal bouton


-  Descriptions from all associated GenBank mRNAs
  AB537500 - Homo sapiens ADCYAP1 mRNA for testis specific precursor of PACAP, partial cds.
AK294233 - Homo sapiens cDNA FLJ56302 complete cds, highly similar to Pituitary adenylate cyclase-activating polypeptide precursor.
JD020867 - Sequence 1891 from Patent EP1572962.
AK313050 - Homo sapiens cDNA, FLJ93525, Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary)(ADCYAP1), mRNA.
JD033403 - Sequence 14427 from Patent EP1572962.
BC101803 - Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary), mRNA (cDNA clone MGC:126852 IMAGE:8069309), complete cds.
BC093837 - Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary), mRNA (cDNA clone MGC:120872 IMAGE:7939682), complete cds.
KJ890631 - Synthetic construct Homo sapiens clone ccsbBroadEn_00025 ADCYAP1 gene, encodes complete protein.
E02722 - DNA encoding human PACAP 38.
E05208 - cDNA encoding human PACAP protein.
S83513 - pituitary adenylate cyclase activating polypeptide [human, mRNA, 1940 nt].
E02721 - DNA encoding human PACAP 38.
JD557127 - Sequence 538151 from Patent EP1572962.
JD565190 - Sequence 546214 from Patent EP1572962.
JD114382 - Sequence 95406 from Patent EP1572962.
JD553343 - Sequence 534367 from Patent EP1572962.
JD416507 - Sequence 397531 from Patent EP1572962.
JD244928 - Sequence 225952 from Patent EP1572962.
JD134302 - Sequence 115326 from Patent EP1572962.
JD422064 - Sequence 403088 from Patent EP1572962.
JD160159 - Sequence 141183 from Patent EP1572962.
JD119558 - Sequence 100582 from Patent EP1572962.
JD025202 - Sequence 6226 from Patent EP1572962.
JD034545 - Sequence 15569 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P18509 (Reactome details) participates in the following event(s):

R-HSA-187678 TRKA activation by PACAP type 1 receptor
R-HSA-420131 The PACAP receptor binds PACAP
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-187024 NGF-independant TRKA activation
R-HSA-187015 Activation of TRKA receptors
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-418555 G alpha (s) signalling events
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-166520 Signaling by NTRKs
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2R7N4, ENST00000450565.1, ENST00000450565.2, ENST00000450565.3, ENST00000450565.4, ENST00000450565.5, ENST00000450565.6, ENST00000450565.7, NM_001099733, P18509, PACA_HUMAN, Q52LQ0, uc320rza.1, uc320rza.2
UCSC ID: ENST00000450565.8_4
RefSeq Accession: NM_001099733.2
Protein: P18509 (aka PACA_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.