ID:ADR1_HUMAN DESCRIPTION: RecName: Full=Adiponectin receptor protein 1; AltName: Full=Progestin and adipoQ receptor family member I; FUNCTION: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin. SUBUNIT: May form homomultimer and heteromultimers. INTERACTION: Self; NbExp=3; IntAct=EBI-1632076, EBI-1632076; Q9UKG1:APPL1; NbExp=6; IntAct=EBI-1632076, EBI-741243; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles. TISSUE SPECIFICITY: Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine. DOMAIN: The N-terminus is known to be cytoplasmic while the C- terminus is known to be extracellular. SIMILARITY: Belongs to the ADIPOR family. SEQUENCE CAUTION: Sequence=AAD34040.1; Type=Frameshift; Positions=369;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96A54
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
