Human Gene ADM (ENST00000278175.10_5) from GENCODE V47lift37
  Description: adrenomedullin (from RefSeq NM_001124.3)
Gencode Transcript: ENST00000278175.10_5
Gencode Gene: ENSG00000148926.10_8
Transcript (Including UTRs)
   Position: hg19 chr11:10,326,620-10,328,944 Size: 2,325 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr11:10,327,248-10,328,188 Size: 941 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:10,326,620-10,328,944)mRNA (may differ from genome)Protein (185 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
ReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ADML_HUMAN
DESCRIPTION: RecName: Full=ADM; Contains: RecName: Full=Adrenomedullin; Short=AM; Contains: RecName: Full=Proadrenomedullin N-20 terminal peptide; AltName: Full=ProAM N-terminal 20 peptide; Short=PAMP; Short=ProAM-N20; Flags: Precursor;
FUNCTION: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.
SIMILARITY: Belongs to the adrenomedullin family.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/adm/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ADM
Diseases sorted by gene-association score: malignant hypertension (13), pheochromocytoma (12), pulmonary hypertension (12), adrenomyeloneuropathy (10), congestive heart failure (10), renal hypertension (8), cardiogenic shock (8), acute pyelonephritis (8), macular holes (7), cerebrovascular disease (7), vitreoretinopathy, neovascular inflammatory (7), renovascular hypertension (6), heart disease (6), kawasaki disease (5), myeloproliferative syndrome, transient (5), hypertension, essential (4), idiopathic edema (3), arteriosclerosis (2), myocardial infarction (2), asthma (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 349.07 RPKM in Cells - Cultured fibroblasts
Total median expression: 1414.37 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -55.00178-0.309 Picture PostScript Text
3' UTR -248.60756-0.329 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001710 - Adrenomedullin
IPR021116 - Procalcitonin/adrenomedullin

Pfam Domains:
PF00214 - Calcitonin / CGRP / IAPP family

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2FLY - NMR 2L7S - NMR MuPIT


ModBase Predicted Comparative 3D Structure on P35318
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0031700 adrenomedullin receptor binding

Biological Process:
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001843 neural tube closure
GO:0002026 regulation of the force of heart contraction
GO:0002031 G-protein coupled receptor internalization
GO:0003073 regulation of systemic arterial blood pressure
GO:0006171 cAMP biosynthetic process
GO:0006701 progesterone biosynthetic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0007507 heart development
GO:0007565 female pregnancy
GO:0007568 aging
GO:0008015 blood circulation
GO:0008209 androgen metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009409 response to cold
GO:0009611 response to wounding
GO:0010033 response to organic substance
GO:0010460 positive regulation of heart rate
GO:0010469 regulation of receptor activity
GO:0019731 antibacterial humoral response
GO:0019933 cAMP-mediated signaling
GO:0030816 positive regulation of cAMP metabolic process
GO:0031100 animal organ regeneration
GO:0031102 neuron projection regeneration
GO:0031623 receptor internalization
GO:0032496 response to lipopolysaccharide
GO:0032868 response to insulin
GO:0035809 regulation of urine volume
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042594 response to starvation
GO:0043065 positive regulation of apoptotic process
GO:0043116 negative regulation of vascular permeability
GO:0045766 positive regulation of angiogenesis
GO:0045906 negative regulation of vasoconstriction
GO:0046879 hormone secretion
GO:0048589 developmental growth
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0051384 response to glucocorticoid
GO:0055074 calcium ion homeostasis
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060712 spongiotrophoblast layer development
GO:0097084 vascular smooth muscle cell development
GO:0097647 amylin receptor signaling pathway
GO:1990410 adrenomedullin receptor signaling pathway
GO:2001214 positive regulation of vasculogenesis
GO:0001878 response to yeast
GO:0019732 antifungal humoral response

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  LF212142 - JP 2014500723-A/19645: Polycomb-Associated Non-Coding RNAs.
AK312893 - Homo sapiens cDNA, FLJ93337, Homo sapiens adrenomedullin (ADM), mRNA.
BC015961 - Homo sapiens adrenomedullin, mRNA (cDNA clone MGC:1811 IMAGE:3506276), complete cds.
D14874 - Homo sapiens mRNA for adrenomedullin precursor, complete cds.
E09705 - cDNA encoding human adrenomedullin.
JD371192 - Sequence 352216 from Patent EP1572962.
LF213098 - JP 2014500723-A/20601: Polycomb-Associated Non-Coding RNAs.
KJ896386 - Synthetic construct Homo sapiens clone ccsbBroadEn_05780 ADM gene, encodes complete protein.
BT006902 - Homo sapiens adrenomedullin mRNA, complete cds.
CR541995 - Homo sapiens full open reading frame cDNA clone RZPDo834A0935D for gene ADM, adrenomedullin; complete cds, incl. stopcodon.
JD392886 - Sequence 373910 from Patent EP1572962.
JD079795 - Sequence 60819 from Patent EP1572962.
JD218649 - Sequence 199673 from Patent EP1572962.
JD480840 - Sequence 461864 from Patent EP1572962.
JD237237 - Sequence 218261 from Patent EP1572962.
JD450547 - Sequence 431571 from Patent EP1572962.
JD469608 - Sequence 450632 from Patent EP1572962.
JD566352 - Sequence 547376 from Patent EP1572962.
JD561761 - Sequence 542785 from Patent EP1572962.
MA447719 - JP 2018138019-A/19645: Polycomb-Associated Non-Coding RNAs.
MA448675 - JP 2018138019-A/20601: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P35318 (Reactome details) participates in the following event(s):

R-HSA-420214 The adrenomedullin receptor can bind adrenomedullin and intermedin
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-419812 Calcitonin-like ligand receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ADML_HUMAN, AM, B2R793, D3DQV3, ENST00000278175.1, ENST00000278175.2, ENST00000278175.3, ENST00000278175.4, ENST00000278175.5, ENST00000278175.6, ENST00000278175.7, ENST00000278175.8, ENST00000278175.9, NM_001124, P35318, Q6FGW2, uc317jnx.1, uc317jnx.2
UCSC ID: ENST00000278175.10_5
RefSeq Accession: NM_001124.3
Protein: P35318 (aka ADML_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.