Human Gene ADO (ENST00000373783.3_4) from GENCODE V47lift37
  Description: 2-aminoethanethiol dioxygenase (from RefSeq NM_032804.6)
Gencode Transcript: ENST00000373783.3_4
Gencode Gene: ENSG00000181915.6_8
Transcript (Including UTRs)
   Position: hg19 chr10:64,564,480-64,568,239 Size: 3,760 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr10:64,564,820-64,565,632 Size: 813 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:64,564,480-64,568,239)mRNA (may differ from genome)Protein (270 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: AEDO_HUMAN
DESCRIPTION: RecName: Full=2-aminoethanethiol dioxygenase; EC=1.13.11.19; AltName: Full=Cysteamine dioxygenase;
CATALYTIC ACTIVITY: 2-aminoethanethiol + O(2) = hypotaurine.
COFACTOR: Iron (By similarity).
SEQUENCE CAUTION: Sequence=BAB55123.1; Type=Erroneous initiation;
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/C10orf2";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ADO
Diseases sorted by gene-association score: acrodysostosis (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 31.84 RPKM in Testis
Total median expression: 351.50 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -197.60340-0.581 Picture PostScript Text
3' UTR -694.202607-0.266 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012864 - Cysteamine_dioxygenase
IPR014710 - RmlC-like_jellyroll
IPR011051 - RmlC_Cupin

Pfam Domains:
PF07847 - PCO_ADO

SCOP Domains:
51182 - RmlC-like cupins
51649 - RuBisCo, C-terminal domain

ModBase Predicted Comparative 3D Structure on Q96SZ5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016491 oxidoreductase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872 metal ion binding
GO:0047800 cysteamine dioxygenase activity
GO:0051213 dioxygenase activity

Biological Process:
GO:0000098 sulfur amino acid catabolic process
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005739 mitochondrion
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  LF208781 - JP 2014500723-A/16284: Polycomb-Associated Non-Coding RNAs.
AK127694 - Homo sapiens cDNA FLJ45793 fis, clone NT2RI2009233.
BC018660 - Homo sapiens 2-aminoethanethiol (cysteamine) dioxygenase, mRNA (cDNA clone MGC:24535 IMAGE:4104391), complete cds.
BC028589 - Homo sapiens 2-aminoethanethiol (cysteamine) dioxygenase, mRNA (cDNA clone MGC:27038 IMAGE:4838951), complete cds.
JD538249 - Sequence 519273 from Patent EP1572962.
BC067740 - Homo sapiens 2-aminoethanethiol (cysteamine) dioxygenase, mRNA (cDNA clone MGC:86991 IMAGE:5295674), complete cds.
JD077363 - Sequence 58387 from Patent EP1572962.
JD473989 - Sequence 455013 from Patent EP1572962.
JD191184 - Sequence 172208 from Patent EP1572962.
AK027453 - Homo sapiens cDNA FLJ14547 fis, clone NT2RM2001637.
LF322765 - JP 2014500723-A/130268: Polycomb-Associated Non-Coding RNAs.
JD078842 - Sequence 59866 from Patent EP1572962.
JD159564 - Sequence 140588 from Patent EP1572962.
JD200945 - Sequence 181969 from Patent EP1572962.
JD399313 - Sequence 380337 from Patent EP1572962.
JD317289 - Sequence 298313 from Patent EP1572962.
JD060759 - Sequence 41783 from Patent EP1572962.
JD215319 - Sequence 196343 from Patent EP1572962.
JD058687 - Sequence 39711 from Patent EP1572962.
JD036460 - Sequence 17484 from Patent EP1572962.
JD555532 - Sequence 536556 from Patent EP1572962.
JD376540 - Sequence 357564 from Patent EP1572962.
JD554184 - Sequence 535208 from Patent EP1572962.
JD550668 - Sequence 531692 from Patent EP1572962.
JD521363 - Sequence 502387 from Patent EP1572962.
JD436288 - Sequence 417312 from Patent EP1572962.
JD145835 - Sequence 126859 from Patent EP1572962.
JD368513 - Sequence 349537 from Patent EP1572962.
AL049319 - Homo sapiens mRNA; cDNA DKFZp564C046 (from clone DKFZp564C046).
JD456137 - Sequence 437161 from Patent EP1572962.
JD306102 - Sequence 287126 from Patent EP1572962.
JD166566 - Sequence 147590 from Patent EP1572962.
JD296432 - Sequence 277456 from Patent EP1572962.
JD359971 - Sequence 340995 from Patent EP1572962.
JD224351 - Sequence 205375 from Patent EP1572962.
JD475480 - Sequence 456504 from Patent EP1572962.
LF322764 - JP 2014500723-A/130267: Polycomb-Associated Non-Coding RNAs.
LF322763 - JP 2014500723-A/130266: Polycomb-Associated Non-Coding RNAs.
JD248480 - Sequence 229504 from Patent EP1572962.
JD553059 - Sequence 534083 from Patent EP1572962.
MA558342 - JP 2018138019-A/130268: Polycomb-Associated Non-Coding RNAs.
MA558341 - JP 2018138019-A/130267: Polycomb-Associated Non-Coding RNAs.
MA558340 - JP 2018138019-A/130266: Polycomb-Associated Non-Coding RNAs.
MA444358 - JP 2018138019-A/16284: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-7850 - taurine biosynthesis II

Reactome (by CSHL, EBI, and GO)

Protein Q96SZ5 (Reactome details) participates in the following event(s):

R-HSA-6814153 ADO oxidises 2AET to HTAU
R-HSA-1614558 Degradation of cysteine and homocysteine
R-HSA-1614635 Sulfur amino acid metabolism
R-HSA-71291 Metabolism of nitrogenous molecules
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: AEDO_HUMAN, B1AL29, C10orf22, ENST00000373783.1, ENST00000373783.2, NM_032804, Q96SZ5, uc318lbc.1, uc318lbc.2
UCSC ID: ENST00000373783.3_4
RefSeq Accession: NM_032804.6
Protein: Q96SZ5 (aka AEDO_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.