Human Gene ADRB1 (ENST00000369295.4_4) from GENCODE V47lift37
  Description: adrenoceptor beta 1 (from RefSeq NM_000684.3)
Gencode Transcript: ENST00000369295.4_4
Gencode Gene: ENSG00000043591.6_8
Transcript (Including UTRs)
   Position: hg19 chr10:115,803,625-115,806,663 Size: 3,039 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr10:115,803,892-115,805,325 Size: 1,434 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:115,803,625-115,806,663)mRNA (may differ from genome)Protein (477 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ADRB1_HUMAN
DESCRIPTION: RecName: Full=Beta-1 adrenergic receptor; AltName: Full=Beta-1 adrenoreceptor; Short=Beta-1 adrenoceptor;
FUNCTION: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
SUBUNIT: Interacts with GOPC, MAGI3 and DLG4.
INTERACTION: Q86UL8:MAGI2; NbExp=2; IntAct=EBI-991009, EBI-311035; Q5TCQ9:MAGI3; NbExp=5; IntAct=EBI-991009, EBI-310506;
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression.
DOMAIN: The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor.
PTM: Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/adrb1/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ADRB1
Diseases sorted by gene-association score: coronary artery disease (31), heart disease (24), congestive heart failure (15), ocular hypotension (13), peripartum cardiomyopathy (12), orthostatic intolerance (12), acute myocardial infarction (11), dilated cardiomyopathy (9), systolic heart failure (9), atrial fibrillation (8), nephrosclerosis (7), meningococcal infection (7), chagas disease (6), intermittent explosive disorder (6), cardiomyopathy (5), aortic coarctation (5), ventricular tachycardia, catecholaminergic polymorphic, 1 (3), long qt syndrome (2), obesity (2), hypertension, essential (2), myocardial infarction (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.15 RPKM in Heart - Left Ventricle
Total median expression: 83.82 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -129.30267-0.484 Picture PostScript Text
3' UTR -367.201338-0.274 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR000507 - Adrgc_rcpt_B1
IPR002233 - Adrnrgc_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx
PF10323 - Serpentine type 7TM GPCR chemoreceptor Srv
PF10328 - Serpentine type 7TM GPCR chemoreceptor Srx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on P08588
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004939 beta-adrenergic receptor activity
GO:0004940 beta1-adrenergic receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0030165 PDZ domain binding
GO:0031694 alpha-2A adrenergic receptor binding
GO:0046982 protein heterodimerization activity
GO:0051379 epinephrine binding
GO:0051380 norepinephrine binding

Biological Process:
GO:0001659 temperature homeostasis
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0002024 diet induced thermogenesis
GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007267 cell-cell signaling
GO:0009409 response to cold
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0031649 heat generation
GO:0040015 negative regulation of multicellular organism growth
GO:0042596 fear response
GO:0043547 positive regulation of GTPase activity
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045823 positive regulation of heart contraction
GO:0050873 brown fat cell differentiation
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway

Cellular Component:
GO:0005768 endosome
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  JD186849 - Sequence 167873 from Patent EP1572962.
JC506674 - Sequence 42 from Patent EP2733220.
JC737786 - Sequence 42 from Patent WO2014075939.
JC506688 - Sequence 56 from Patent EP2733220.
JC737800 - Sequence 56 from Patent WO2014075939.
HV708923 - JP 2012506450-A/21: Methods for treating eye disorders.
JA482048 - Sequence 31 from Patent WO2011072091.
JE980340 - Sequence 31 from Patent EP2862929.
J03019 - Human beta-1-adrenergic receptor mRNA, complete cds.
JD549764 - Sequence 530788 from Patent EP1572962.
JD554693 - Sequence 535717 from Patent EP1572962.
BC169224 - Synthetic construct Homo sapiens clone IMAGE:9093416 beta-1-adrenergic receptor (ADRB1) gene, partial cds.
BC169225 - Synthetic construct Homo sapiens clone IMAGE:9093417 beta-1-adrenergic receptor (ADRB1) gene, partial cds.
BC169226 - Synthetic construct Homo sapiens clone IMAGE:9093418 beta-1-adrenergic receptor (ADRB1) gene, partial cds.
BC169227 - Synthetic construct Homo sapiens clone IMAGE:9093419 beta-1-adrenergic receptor (ADRB1) gene, partial cds.
JD417188 - Sequence 398212 from Patent EP1572962.
JD163545 - Sequence 144569 from Patent EP1572962.
JD529926 - Sequence 510950 from Patent EP1572962.
JD456547 - Sequence 437571 from Patent EP1572962.
U29690 - Human beta1-adrenergic receptor mRNA, 3'untranslated region.
JD501340 - Sequence 482364 from Patent EP1572962.
JD096682 - Sequence 77706 from Patent EP1572962.
AF272890 - Homo sapiens beta-1 adrenergic receptor mRNA, 3' UTR.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P08588 (Reactome details) participates in the following event(s):

R-HSA-390674 Beta adrenoceptors bind catecholamines
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-390696 Adrenoceptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-375280 Amine ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ADRB1 , ADRB1R, ADRB1_HUMAN, B0LPE2, B1AR, ENST00000369295.1, ENST00000369295.2, ENST00000369295.3, NM_000684, P08588, Q5T5Y4, Q9UKG7, Q9UKG8, uc318hma.1, uc318hma.2
UCSC ID: ENST00000369295.4_4
RefSeq Accession: NM_000684.3
Protein: P08588 (aka ADRB1_HUMAN or B1AR_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.