Human Gene ADRB2 (ENST00000305988.6_4) from GENCODE V47lift37
  Description: adrenoceptor beta 2 (from RefSeq NM_000024.6)
Gencode Transcript: ENST00000305988.6_4
Gencode Gene: ENSG00000169252.6_5
Transcript (Including UTRs)
   Position: hg19 chr5:148,206,174-148,208,186 Size: 2,013 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr5:148,206,395-148,207,636 Size: 1,242 Coding Exon Count: 1 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:148,206,174-148,208,186)mRNA (may differ from genome)Protein (413 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ADRB2
Diseases sorted by gene-association score: asthma* (313), obesity* (256), asthma susceptibility, adrb2-related* (100), obesity susceptibility, adrb2-related* (41), status asthmaticus (17), ocular hypotension (10), pulmonary disease, chronic obstructive (10), pain disorder (9), perinephritis (8), whim syndrome (8), meningococcal infection (8), congestive heart failure (8), thyrotoxic periodic paralysis (7), asthenopia (6), interstitial cystitis (6), acute mountain sickness (6), aortic coarctation (5), pollen allergy (5), heart disease (5), orthostatic intolerance (5), acute insulin response (5), bronchial disease (4), hypertension, essential (4), atopy (3), cystic fibrosis (2), dilated cardiomyopathy (2), myocardial infarction (2), respiratory system disease (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.71 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 191.68 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -81.60221-0.369 Picture PostScript Text
3' UTR -125.92550-0.229 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  M15169 - Human beta-2-adrenergic receptor mRNA, complete cds.
LF212749 - JP 2014500723-A/20252: Polycomb-Associated Non-Coding RNAs.
LF211071 - JP 2014500723-A/18574: Polycomb-Associated Non-Coding RNAs.
AK313151 - Homo sapiens cDNA, FLJ93644, highly similar to Homo sapiens adrenergic, beta-2-, receptor, surface (ADRB2), mRNA.
BC012481 - Homo sapiens adrenergic, beta-2-, receptor, surface, mRNA (cDNA clone MGC:21367 IMAGE:4538187), complete cds.
AK223025 - Homo sapiens mRNA for Adrenergic, beta-2-, receptor, surface variant, clone: JTH06683.
BC073856 - Homo sapiens adrenergic, beta-2-, receptor, surface, mRNA (cDNA clone MGC:90247 IMAGE:5217922), complete cds.
BC063486 - Homo sapiens adrenergic, beta-2-, receptor, surface, mRNA (cDNA clone MGC:74793 IMAGE:5241774), complete cds.
X04827 - Human mRNA for brain beta-adrenergic receptor.
JD252938 - Sequence 233962 from Patent EP1572962.
JD097381 - Sequence 78405 from Patent EP1572962.
JD053866 - Sequence 34890 from Patent EP1572962.
AB590698 - Synthetic construct DNA, clone: pFN21AE1887, Homo sapiens ADRB2 gene for adrenergic, beta-2-, receptor, surface, without stop codon, in Flexi system.
KJ896392 - Synthetic construct Homo sapiens clone ccsbBroadEn_05786 ADRB2 gene, encodes complete protein.
KR711409 - Synthetic construct Homo sapiens clone CCSBHm_00023432 ADRB2 (ADRB2) mRNA, encodes complete protein.
KR711410 - Synthetic construct Homo sapiens clone CCSBHm_00023433 ADRB2 (ADRB2) mRNA, encodes complete protein.
KJ534762 - Homo sapiens clone ADRB2_iso-A_adult-A03 adrenoceptor beta 2 surface isoform A (ADRB2) mRNA, partial cds, alternatively spliced.
AY136741 - Homo sapiens beta 2 adrenergic receptor (ADRB2) mRNA, complete cds.
LF343739 - JP 2014500723-A/151242: Polycomb-Associated Non-Coding RNAs.
JD509513 - Sequence 490537 from Patent EP1572962.
JD079808 - Sequence 60832 from Patent EP1572962.
JD288448 - Sequence 269472 from Patent EP1572962.
JD163899 - Sequence 144923 from Patent EP1572962.
JD141446 - Sequence 122470 from Patent EP1572962.
JD163617 - Sequence 144641 from Patent EP1572962.
JD429846 - Sequence 410870 from Patent EP1572962.
JD359278 - Sequence 340302 from Patent EP1572962.
JD208045 - Sequence 189069 from Patent EP1572962.
MA579316 - JP 2018138019-A/151242: Polycomb-Associated Non-Coding RNAs.
MA448326 - JP 2018138019-A/20252: Polycomb-Associated Non-Coding RNAs.
MA446648 - JP 2018138019-A/18574: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_cftrPathway - Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway
h_plcePathway - Phospholipase C-epsilon pathway
h_gcrPathway - Corticosteroids and cardioprotection

-  Other Names for This Gene
  Alternate Gene Symbols: ADRB2 , ENST00000305988.1, ENST00000305988.2, ENST00000305988.3, ENST00000305988.4, ENST00000305988.5, NM_000024, uc317nsr.1, uc317nsr.2, X5DQM5, X5DQM5_HUMAN
UCSC ID: ENST00000305988.6_4
RefSeq Accession: NM_000024.6

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.