Human Gene ADRM1 (ENST00000253003.7_5) from GENCODE V47lift37
  Description: ADRM1 26S proteasome ubiquitin receptor, transcript variant 2 (from RefSeq NM_175573.2)
Gencode Transcript: ENST00000253003.7_5
Gencode Gene: ENSG00000130706.13_10
Transcript (Including UTRs)
   Position: hg19 chr20:60,878,053-60,883,918 Size: 5,866 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr20:60,878,625-60,883,817 Size: 5,193 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:60,878,053-60,883,918)mRNA (may differ from genome)Protein (407 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ADRM1_HUMAN
DESCRIPTION: RecName: Full=Proteasomal ubiquitin receptor ADRM1; AltName: Full=110 kDa cell membrane glycoprotein; Short=Gp110; AltName: Full=Adhesion-regulating molecule 1; Short=ARM-1; AltName: Full=Proteasome regulatory particle non-ATPase 13; Short=hRpn13; AltName: Full=Rpn13 homolog;
FUNCTION: Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity.
SUBUNIT: Interacts with PSMD1, ubiquitin and UCHL5.
INTERACTION: Q9Y5K5:UCHL5; NbExp=7; IntAct=EBI-954387, EBI-1051183;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
DOMAIN: The PH domain mediates interactions with PSMD1 and ubiquitin. Preferential binding to the proximal subunit of K48- linked diubiquitin allows UCHL5 access to the distal subunit (By similarity).
SIMILARITY: Belongs to the ADRM1 family.
SIMILARITY: Contains 1 PH domain.
CAUTION: Although initially described as a cell membrane glycoprotein, ADRM1 is intracellular and non-glycosylated, and has probably no direct role in cell adhesion.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D001564 Benzo(a)pyrene
  • C006253 pirinixic acid
  • C495626 14-deoxy-11,12-didehydroandrographolide
  • C016403 2,4-dinitrotoluene
  • C023514 2,6-dinitrotoluene
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • C068805 4-hydroxycoumarin
  • D000643 Ammonium Chloride
  • D002945 Cisplatin
  • D019327 Copper Sulfate
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 78.92 RPKM in Testis
Total median expression: 1574.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.6054-0.307 Picture PostScript Text
3' UTR -17.20101-0.170 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006773 - 26S_Psome_Ubiquitin-recp_Rpn13

Pfam Domains:
PF04683 - Proteasome complex subunit Rpn13 ubiquitin receptor
PF16550 - UCH-binding domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2KQZ - NMR MuPIT 2KR0 - NMR MuPIT 2L5V - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q16186
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0002020 protease binding
GO:0005515 protein binding
GO:0043130 ubiquitin binding
GO:0061133 endopeptidase activator activity
GO:0070628 proteasome binding

Biological Process:
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0010950 positive regulation of endopeptidase activity
GO:0016579 protein deubiquitination
GO:0043248 proteasome assembly

Cellular Component:
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008541 proteasome regulatory particle, lid subcomplex
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AK307459 - Homo sapiens cDNA, FLJ97407.
JD076266 - Sequence 57290 from Patent EP1572962.
BC017245 - Homo sapiens adhesion regulating molecule 1, mRNA (cDNA clone MGC:29536 IMAGE:4890786), complete cds.
BC093021 - Homo sapiens cDNA clone IMAGE:30340071, containing frame-shift errors.
BC003059 - Homo sapiens cDNA clone IMAGE:2987785, containing frame-shift errors.
AK297567 - Homo sapiens cDNA FLJ56666 complete cds, highly similar to Adhesion-regulating molecule 1 precursor.
D64154 - Homo sapiens mRNA for Mr 110,000 antigen, complete cds.
CR749213 - Homo sapiens mRNA; cDNA DKFZp686G2045 (from clone DKFZp686G2045).
CU677879 - Synthetic construct Homo sapiens gateway clone IMAGE:100017643 5' read ADRM1 mRNA.
AB590265 - Synthetic construct DNA, clone: pFN21AE1491, Homo sapiens ADRM1 gene for adhesion regulating molecule 1, without stop codon, in Flexi system.
DQ893320 - Synthetic construct clone IMAGE:100005950; FLH196140.01X; RZPDo839E01154D adhesion regulating molecule 1 (ADRM1) gene, encodes complete protein.
DQ896635 - Synthetic construct Homo sapiens clone IMAGE:100011095; FLH196136.01L; RZPDo839E01153D adhesion regulating molecule 1 (ADRM1) gene, encodes complete protein.
KJ898340 - Synthetic construct Homo sapiens clone ccsbBroadEn_07734 ADRM1 gene, encodes complete protein.
AK054985 - Homo sapiens cDNA FLJ30423 fis, clone BRACE2008867, highly similar to 110 KD CELL MEMBRANE GLYCOPROTEIN.
BC010733 - Homo sapiens, clone IMAGE:3897044, mRNA, partial cds.
JD398189 - Sequence 379213 from Patent EP1572962.
JD127849 - Sequence 108873 from Patent EP1572962.
JD138688 - Sequence 119712 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q16186 (Reactome details) participates in the following event(s):

R-HSA-5665871 ADRM1 binds 26S proteasome
R-HSA-5665854 ADRM1:26S proteaseome binds UCHL5
R-HSA-5689539 ADRM1:26S proteaseome binds USP14
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
R-HSA-5688426 Deubiquitination
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: A0PKB1, ADRM1_HUMAN, ENST00000253003.1, ENST00000253003.2, ENST00000253003.3, ENST00000253003.4, ENST00000253003.5, ENST00000253003.6, GP110, NM_175573, Q16186, Q96FJ7, Q9H1P2, uc317fjp.1, uc317fjp.2
UCSC ID: ENST00000253003.7_5
RefSeq Accession: NM_007002.4
Protein: Q16186 (aka ADRM1_HUMAN or ADRM_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.