ID:AES_HUMAN DESCRIPTION: RecName: Full=Amino-terminal enhancer of split; Short=Amino enhancer of split; AltName: Full=Gp130-associated protein GAM; AltName: Full=Protein ESP1; AltName: Full=Protein GRG; FUNCTION: Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. SUBUNIT: Homooligomer and heterooligomer with other family members. Binds TCF7 (By similarity). Binds the NF-kappa-B subunit RELA. Interacts with PHF12. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver. DOMAIN: Lacks the C-terminal WD repeats. PTM: Ubiquitinated by XIAP/BIRC4. SIMILARITY: Belongs to the WD repeat Groucho/TLE family. SEQUENCE CAUTION: Sequence=AAC35517.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q08117
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003714 transcription corepressor activity GO:0005515 protein binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001501 skeletal system development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0009887 animal organ morphogenesis GO:0010629 negative regulation of gene expression GO:0016055 Wnt signaling pathway GO:0031668 cellular response to extracellular stimulus GO:0032091 negative regulation of protein binding GO:0040008 regulation of growth GO:0045892 negative regulation of transcription, DNA-templated GO:0060761 negative regulation of response to cytokine stimulus GO:0070555 response to interleukin-1 GO:0090090 negative regulation of canonical Wnt signaling pathway GO:2000210 positive regulation of anoikis
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
