ID:AGK_HUMAN DESCRIPTION: RecName: Full=Acylglycerol kinase, mitochondrial; Short=hAGK; EC=2.7.1.107; EC=2.7.1.94; AltName: Full=Multiple substrate lipid kinase; Short=HsMuLK; Short=MuLK; Short=Multi-substrate lipid kinase; Flags: Precursor; FUNCTION: Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth. CATALYTIC ACTIVITY: ATP + acylglycerol = ADP + acyl-sn-glycerol 3- phosphate. CATALYTIC ACTIVITY: ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl- sn-glycerol 3-phosphate. COFACTOR: Magnesium. PATHWAY: Lipid metabolism; glycerolipid metabolism. SUBCELLULAR LOCATION: Mitochondrion membrane. TISSUE SPECIFICITY: Highly expressed in muscle, heart, kidney and brain. DISEASE: Defects in AGK are the cause of mitochondrial DNA depletion syndrome type 10 (MTDPS10) [MIM:212350]. An autosomal recessive mitochondrial disorder characterized by congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, exercise intolerance, and lactic acidosis. Mental development is normal, but affected individuals may die early from cardiomyopathy. DISEASE: Defects in AGK are the cause of cataract, congenital, autosomal recessive type 5 (CATC5) [MIM:614691]. CATC5 consists of an opacification of the crystalline lens of the eye becoming evident at birth. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. MISCELLANEOUS: Overexpressed in prostate cancer, suggesting that it may play a role in initiation and progression of prostate cancer, processes in which LPA plays key roles. SIMILARITY: Contains 1 DAGKc domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 111331 - NAD kinase/diacylglycerol kinase-like
ModBase Predicted Comparative 3D Structure on Q53H12
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0008152 metabolic process GO:0016310 phosphorylation GO:0045039 protein import into mitochondrial inner membrane GO:0046474 glycerophospholipid biosynthetic process GO:0046486 glycerolipid metabolic process GO:0046513 ceramide biosynthetic process GO:0046834 lipid phosphorylation
Cellular Component: GO:0005739 mitochondrion GO:0005741 mitochondrial outer membrane GO:0005743 mitochondrial inner membrane GO:0005758 mitochondrial intermembrane space GO:0005829 cytosol GO:0016020 membrane GO:0031305 integral component of mitochondrial inner membrane GO:0042721 mitochondrial inner membrane protein insertion complex GO:0043231 intracellular membrane-bounded organelle
Descriptions from all associated GenBank mRNAs
LF207097 - JP 2014500723-A/14600: Polycomb-Associated Non-Coding RNAs. AK304502 - Homo sapiens cDNA FLJ61206 complete cds, highly similar to Homo sapiens multiple substrate lipid kinase (MULK), mRNA. AK299131 - Homo sapiens cDNA FLJ59963 complete cds, highly similar to Homo sapiens multiple substrate lipid kinase (MULK), mRNA. AK001704 - Homo sapiens cDNA FLJ10842 fis, clone NT2RP4001343. AK222769 - Homo sapiens mRNA for multi-substrate lipid kinase variant, clone: HEP00214. AJ278150 - Homo sapiens mRNA for putative lipid kinase. BC022777 - Homo sapiens acylglycerol kinase, mRNA (cDNA clone MGC:8807 IMAGE:3913448), complete cds. CU692704 - Synthetic construct Homo sapiens gateway clone IMAGE:100018247 5' read AGK mRNA. KJ899183 - Synthetic construct Homo sapiens clone ccsbBroadEn_08577 AGK gene, encodes complete protein. KJ905501 - Synthetic construct Homo sapiens clone ccsbBroadEn_15107 AGK gene, encodes complete protein. MA442674 - JP 2018138019-A/14600: Polycomb-Associated Non-Coding RNAs. BC009775 - Homo sapiens acylglycerol kinase, mRNA (cDNA clone IMAGE:4092662), complete cds. KJ906243 - Synthetic construct Homo sapiens clone ccsbBroadEn_15913 AGK gene, encodes complete protein. LF361911 - JP 2014500723-A/169414: Polycomb-Associated Non-Coding RNAs. MA597488 - JP 2018138019-A/169414: Polycomb-Associated Non-Coding RNAs. BC040877 - Homo sapiens cDNA clone IMAGE:5724291, **** WARNING: chimeric clone ****. LF361931 - JP 2014500723-A/169434: Polycomb-Associated Non-Coding RNAs. JD120694 - Sequence 101718 from Patent EP1572962. JD188461 - Sequence 169485 from Patent EP1572962. JD038876 - Sequence 19900 from Patent EP1572962. JD386530 - Sequence 367554 from Patent EP1572962. JD475933 - Sequence 456957 from Patent EP1572962. JD079340 - Sequence 60364 from Patent EP1572962. JD047359 - Sequence 28383 from Patent EP1572962. JD432016 - Sequence 413040 from Patent EP1572962. JD317726 - Sequence 298750 from Patent EP1572962. JD286499 - Sequence 267523 from Patent EP1572962. MA597508 - JP 2018138019-A/169434: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q53H12 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
