Human Gene AGO1 (ENST00000373204.6_4) from GENCODE V47lift37
Description: argonaute RISC component 1, transcript variant 1 (from RefSeq NM_012199.5)
Gencode Transcript: ENST00000373204.6_4
Gencode Gene: ENSG00000092847.14_13
Transcript (Including UTRs)
Position: hg19 chr1:36,348,810-36,396,133 Size: 47,324 Total Exon Count: 19 Strand: +
Coding Region
Position: hg19 chr1:36,349,023-36,385,208 Size: 36,186 Coding Exon Count: 19
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: AGO1_HUMAN
DESCRIPTION: RecName: Full=Protein argonaute-1; Short=Argonaute1; Short=hAgo1; AltName: Full=Eukaryotic translation initiation factor 2C 1; Short=eIF-2C 1; Short=eIF2C 1; AltName: Full=Putative RNA-binding protein Q99;
FUNCTION: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).SUBUNIT: Interacts with DDB1, DDX5, DDX6, DHX30, DHX36, DDX47, DICER1, EIF2C2/AGO2, ELAVL1, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, MOV10, PABPC1, PRMT5, RBM4, SART3, TNRC6B, UPF1 and YBX1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with LIMD1, WTIP and AJUBA.INTERACTION: Q9UPY3:DICER1; NbExp=2; IntAct=EBI-527363, EBI-395506; O15397:IPO8; NbExp=2; IntAct=EBI-527363, EBI-358808;SUBCELLULAR LOCATION: Cytoplasm, P-body.SIMILARITY: Belongs to the argonaute family. Ago subfamily.SIMILARITY: Contains 1 PAZ domain.SIMILARITY: Contains 1 Piwi domain.
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR014811 - DUF1785
IPR003100 - PAZ
IPR003165 - Piwi
IPR012337 - RNaseH-like_dom
Pfam Domains: PF02170 - PAZ domain
PF02171 - Piwi domain
PF08699 - Argonaute linker 1 domain
PF16486 - N-terminal domain of argonaute
PF16487 - Mid domain of argonaute
PF16488 - Argonaute linker 2 domain
SCOP Domains: 101690 - PAZ domain
53098 - Ribonuclease H-like
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q9UL18
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK001622 - Homo sapiens cDNA FLJ10760 fis, clone NT2RP3004618, highly similar to Eukaryotic translation initiation factor 2C 1.JD060486 - Sequence 41510 from Patent EP1572962.AF093097 - Homo sapiens putative RNA-binding protein Q99 mRNA, complete cds.BC063275 - Homo sapiens eukaryotic translation initiation factor 2C, 1, mRNA (cDNA clone MGC:71487 IMAGE:30344513), complete cds.AK314148 - Homo sapiens cDNA, FLJ94852, highly similar to Homo sapiens eukaryotic translation initiation factor 2C, 1 (EIF2C1), mRNA.JD409007 - Sequence 390031 from Patent EP1572962.JD484920 - Sequence 465944 from Patent EP1572962.JD443987 - Sequence 425011 from Patent EP1572962.KJ898629 - Synthetic construct Homo sapiens clone ccsbBroadEn_08023 EIF2C1 gene, encodes complete protein.AB385028 - Synthetic construct DNA, clone: pF1KB5078, Homo sapiens EIF2C1 gene for eukaryotic translation initiation factor 2C 1, complete cds, without stop codon, in Flexi system.CR936823 - Homo sapiens mRNA; cDNA DKFZp686M13167 (from clone DKFZp686M13167).DQ595629 - Homo sapiens piRNA piR-61741, complete sequence.AK002003 - Homo sapiens cDNA FLJ11141 fis, clone PLACE1006531.JD380716 - Sequence 361740 from Patent EP1572962.JD304876 - Sequence 285900 from Patent EP1572962.JD516890 - Sequence 497914 from Patent EP1572962.JD309419 - Sequence 290443 from Patent EP1572962.JD340316 - Sequence 321340 from Patent EP1572962.JD481896 - Sequence 462920 from Patent EP1572962.JD236883 - Sequence 217907 from Patent EP1572962.JD390374 - Sequence 371398 from Patent EP1572962.JD052497 - Sequence 33521 from Patent EP1572962.JD084450 - Sequence 65474 from Patent EP1572962.JD184506 - Sequence 165530 from Patent EP1572962.AK027611 - Homo sapiens cDNA FLJ14705 fis, clone NT2RP3000562, highly similar to Homo sapiens putative RNA-binding protein Q99 mRNA.JD124455 - Sequence 105479 from Patent EP1572962.JD493231 - Sequence 474255 from Patent EP1572962.JD438547 - Sequence 419571 from Patent EP1572962.JD237784 - Sequence 218808 from Patent EP1572962.JD185983 - Sequence 167007 from Patent EP1572962.JD262969 - Sequence 243993 from Patent EP1572962.JD218923 - Sequence 199947 from Patent EP1572962.JD220541 - Sequence 201565 from Patent EP1572962.JD340423 - Sequence 321447 from Patent EP1572962.JD382226 - Sequence 363250 from Patent EP1572962.JD434872 - Sequence 415896 from Patent EP1572962.JD359527 - Sequence 340551 from Patent EP1572962.JD120109 - Sequence 101133 from Patent EP1572962.JD087788 - Sequence 68812 from Patent EP1572962.JD288940 - Sequence 269964 from Patent EP1572962.JD165361 - Sequence 146385 from Patent EP1572962.JD518508 - Sequence 499532 from Patent EP1572962.JD323747 - Sequence 304771 from Patent EP1572962.JD467113 - Sequence 448137 from Patent EP1572962.JD229806 - Sequence 210830 from Patent EP1572962.JD297977 - Sequence 279001 from Patent EP1572962.JD547433 - Sequence 528457 from Patent EP1572962.JD214826 - Sequence 195850 from Patent EP1572962.JD359550 - Sequence 340574 from Patent EP1572962.JD430817 - Sequence 411841 from Patent EP1572962.JD543904 - Sequence 524928 from Patent EP1572962.JD494536 - Sequence 475560 from Patent EP1572962.JD262884 - Sequence 243908 from Patent EP1572962.JD339850 - Sequence 320874 from Patent EP1572962.JD329517 - Sequence 310541 from Patent EP1572962.JD172813 - Sequence 153837 from Patent EP1572962.JD435236 - Sequence 416260 from Patent EP1572962.JD281057 - Sequence 262081 from Patent EP1572962.JD146996 - Sequence 128020 from Patent EP1572962.JD171954 - Sequence 152978 from Patent EP1572962.JD526940 - Sequence 507964 from Patent EP1572962.JD074797 - Sequence 55821 from Patent EP1572962.JD474860 - Sequence 455884 from Patent EP1572962.JD077175 - Sequence 58199 from Patent EP1572962.JD348345 - Sequence 329369 from Patent EP1572962.JD525967 - Sequence 506991 from Patent EP1572962.JD319148 - Sequence 300172 from Patent EP1572962.JD275119 - Sequence 256143 from Patent EP1572962.JD500775 - Sequence 481799 from Patent EP1572962.JD259230 - Sequence 240254 from Patent EP1572962.JD295197 - Sequence 276221 from Patent EP1572962.JD082148 - Sequence 63172 from Patent EP1572962.AK000326 - Homo sapiens cDNA FLJ20319 fis, clone HEP08731.DQ595010 - Homo sapiens piRNA piR-61122, complete sequence.JD215107 - Sequence 196131 from Patent EP1572962.JD521987 - Sequence 503011 from Patent EP1572962.JD201658 - Sequence 182682 from Patent EP1572962.JD458960 - Sequence 439984 from Patent EP1572962.JD193953 - Sequence 174977 from Patent EP1572962.JD422804 - Sequence 403828 from Patent EP1572962.JD193954 - Sequence 174978 from Patent EP1572962.JD422805 - Sequence 403829 from Patent EP1572962.JD193955 - Sequence 174979 from Patent EP1572962.JD193956 - Sequence 174980 from Patent EP1572962.JD193959 - Sequence 174983 from Patent EP1572962.JD193961 - Sequence 174985 from Patent EP1572962.DQ577919 - Homo sapiens piRNA piR-46031, complete sequence.JD135054 - Sequence 116078 from Patent EP1572962.JD135055 - Sequence 116079 from Patent EP1572962.JD473129 - Sequence 454153 from Patent EP1572962.JD378969 - Sequence 359993 from Patent EP1572962.JD072573 - Sequence 53597 from Patent EP1572962.JD154384 - Sequence 135408 from Patent EP1572962.JD171192 - Sequence 152216 from Patent EP1572962.JD502132 - Sequence 483156 from Patent EP1572962.JD343979 - Sequence 325003 from Patent EP1572962.JD206541 - Sequence 187565 from Patent EP1572962.JD298713 - Sequence 279737 from Patent EP1572962.JD480576 - Sequence 461600 from Patent EP1572962.U92986 - Homo sapiens clone DT1P1C6 mRNA, CAG repeat region.JD343395 - Sequence 324419 from Patent EP1572962.JD066744 - Sequence 47768 from Patent EP1572962.JD046637 - Sequence 27661 from Patent EP1572962.JD324597 - Sequence 305621 from Patent EP1572962.JD251003 - Sequence 232027 from Patent EP1572962.JD380449 - Sequence 361473 from Patent EP1572962.JD167869 - Sequence 148893 from Patent EP1572962.JD508061 - Sequence 489085 from Patent EP1572962.JD068318 - Sequence 49342 from Patent EP1572962.JD236398 - Sequence 217422 from Patent EP1572962.JD447899 - Sequence 428923 from Patent EP1572962.JD252357 - Sequence 233381 from Patent EP1572962.LF206617 - JP 2014500723-A/14120: Polycomb-Associated Non-Coding RNAs.AK125879 - Homo sapiens cDNA FLJ43891 fis, clone TESTI4009454.DQ571915 - Homo sapiens piRNA piR-40027, complete sequence.AK025726 - Homo sapiens cDNA: FLJ22073 fis, clone HEP11868.JD070579 - Sequence 51603 from Patent EP1572962.JD203764 - Sequence 184788 from Patent EP1572962.JD505558 - Sequence 486582 from Patent EP1572962.LF356595 - JP 2014500723-A/164098: Polycomb-Associated Non-Coding RNAs.LF356594 - JP 2014500723-A/164097: Polycomb-Associated Non-Coding RNAs.MA442194 - JP 2018138019-A/14120: Polycomb-Associated Non-Coding RNAs.MA592172 - JP 2018138019-A/164098: Polycomb-Associated Non-Coding RNAs.MA592171 - JP 2018138019-A/164097: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: AGO1_HUMAN, EIF2C1, ENST00000373204.1, ENST00000373204.2, ENST00000373204.3, ENST00000373204.4, ENST00000373204.5, NM_012199, Q5TA57, Q6P4S0, Q9UL18, uc318kos.1, uc318kos.2UCSC ID: ENST00000373204.6_4RefSeq Accession: NM_001317122.2
Protein: Q9UL18
(aka AGO1_HUMAN)
Gene Model Information
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.