Human Gene AGR2 (ENST00000419304.7_7) from GENCODE V47lift37

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Description: anterior gradient 2, protein disulphide isomerase family member (from RefSeq NM_006408.4)
Gencode Transcript: ENST00000419304.7_7
Gencode Gene: ENSG00000106541.12_9
Transcript (Including UTRs)
Position: hg19 chr7:16,831,435-16,844,623 Size: 13,189 Total Exon Count: 8 Strand: -
Coding Region
Position: hg19 chr7:16,832,532-16,841,420 Size: 8,889 Coding Exon Count: 7

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr7:16,831,435-16,844,623)			mRNA (may differ from genome)		Protein (175 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: AGR2 Diseases sorted by gene-association score: pancreatic ductal adenocarcinoma (3)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D004997 Ethinyl Estradiol D013739 Testosterone D013749 Tetrachlorodibenzodioxin D015056 1-Methyl-3-isobutylxanthine C031903 1-UFT protocol C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone C023514 2,6-dinitrotoluene D015124 8-Bromo Cyclic Adenosine Monophosphate D017632 Asbestos, Serpentine more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 177.92 RPKM in Stomach Total median expression: 570.65 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-22.20	72	-0.308	Picture	PostScript	Text
3' UTR	-267.00	1097	-0.243	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR012336 - Thioredoxin-like_fold

Pfam Domains:
PF13899 - Thioredoxin-like

SCOP Domains:
52833 - Thioredoxin-like

ModBase Predicted Comparative 3D Structure on Q4JM46


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Biological Process: GO:0048546 digestive tract morphogenesis GO:0048639 positive regulation of developmental growth GO:0060480 lung goblet cell differentiation GO:0070254 mucus secretion Cellular Component: GO:0005783 endoplasmic reticulum

Descriptions from all associated GenBank mRNAs


	AF038452 - Homo sapiens secreted cement gland protein XAG-2 homolog (hAG-2/I) mRNA, 3' untranslated region. AF115926 - Homo sapiens XAG-2 homolog long protein (HPC8) mRNA, complete cds. JD417819 - Sequence 398843 from Patent EP1572962. JD486595 - Sequence 467619 from Patent EP1572962. JD307609 - Sequence 288633 from Patent EP1572962. JD037211 - Sequence 18235 from Patent EP1572962. JD541196 - Sequence 522220 from Patent EP1572962. JD254526 - Sequence 235550 from Patent EP1572962. JD379411 - Sequence 360435 from Patent EP1572962. JD359529 - Sequence 340553 from Patent EP1572962. AF038451 - Homo sapiens secreted cement gland protein XAG-2 homolog (hAG-2/R) mRNA, complete cds. JD043078 - Sequence 24102 from Patent EP1572962. JD046642 - Sequence 27666 from Patent EP1572962. JD298302 - Sequence 279326 from Patent EP1572962. AF007791 - Homo sapiens secreted cement gland protein XAG-2 homolog (hAG-2/C) mRNA, complete cds. FJ224307 - Homo sapiens epididymis secretory protein Li 116 (HEL-S-116) mRNA, complete cds. AK223067 - Homo sapiens mRNA for anterior gradient 2 homolog, clone: KAT02605. AF088867 - Homo sapiens putative secreted protein XAG mRNA, complete cds. AF087879 - Homo sapiens GOB-4 mRNA, complete cds. AY359009 - Homo sapiens clone DNA59485 AGR2 (UNQ515) mRNA, complete cds. BC015503 - Homo sapiens anterior gradient homolog 2 (Xenopus laevis), mRNA (cDNA clone MGC:9112 IMAGE:3852448), complete cds. KJ767790 - Homo sapiens anterior gradient 2 splice variant D (AGR2) mRNA sequence, alternatively spliced. KJ767791 - Homo sapiens anterior gradient 2 splice variant E (AGR2) mRNA sequence, alternatively spliced. KJ767792 - Homo sapiens anterior gradient 2 splice variant F (AGR2) mRNA sequence, alternatively spliced. KJ767789 - Homo sapiens anterior gradient 2 splice variant C (AGR2) mRNA, complete cds, alternatively spliced. KJ767793 - Homo sapiens anterior gradient 2 splice variant H (AGR2) mRNA sequence, alternatively spliced. LQ244814 - Sequence 1 from Patent WO2016040321. LY511474 - KR 1020170058960-A/1: BLOCKING MONOCLONAL ANTIBODIES TO AGR2 AND ITS RECEPTOR C4.4A. LZ992903 - JP 2017534251-A/1: BLOCKING MONOCLONAL ANTIBODIES TO AGR2 AND ITS RECEPTOR C4.4A. AK312942 - Homo sapiens cDNA, FLJ93394, highly similar to Homo sapiens anterior gradient 2 homolog (Xenopus laevis) (AGR2), mRNA. BT007048 - Homo sapiens anterior gradient 2 homolog (Xenepus laevis) mRNA, complete cds. DQ890645 - Synthetic construct clone IMAGE:100003275; FLH164743.01X; RZPDo839B06158D anterior gradient 2 homolog (Xenopus laevis) (AGR2) gene, encodes complete protein. DQ893825 - Synthetic construct Homo sapiens clone IMAGE:100008285; FLH164739.01L; RZPDo839B06157D anterior gradient 2 homolog (Xenopus laevis) (AGR2) gene, encodes complete protein. AK124419 - Homo sapiens cDNA FLJ42428 fis, clone BLADE2004628. AK296721 - Homo sapiens cDNA FLJ57522 complete cds, weakly similar to Anterior gradient protein 2 homolog precursor.

Other Names for This Gene


	Alternate Gene Symbols: AGR2 , ENST00000419304.1, ENST00000419304.2, ENST00000419304.3, ENST00000419304.4, ENST00000419304.5, ENST00000419304.6, hCG_19292 , HEL-S-116 , NM_006408, Q4JM46, Q4JM46_HUMAN, tcag7.197 , uc319ovy.1, uc319ovy.2 UCSC ID: ENST00000419304.7_7 RefSeq Accession: NM_006408.4 Protein: Q4JM46

Gene Model Information


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Methods, Credits, and Use Restrictions


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