Human Gene AGTR1 (ENST00000349243.8_8) from GENCODE V47lift37
  Description: angiotensin II receptor type 1, transcript variant 4 (from RefSeq NM_031850.4)
Gencode Transcript: ENST00000349243.8_8
Gencode Gene: ENSG00000144891.19_8
Transcript (Including UTRs)
   Position: hg19 chr3:148,415,690-148,460,790 Size: 45,101 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr3:148,458,823-148,459,902 Size: 1,080 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:148,415,690-148,460,790)mRNA (may differ from genome)Protein (359 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q53YY0_HUMAN
DESCRIPTION: SubName: Full=Angiotensin II receptor, type 1; SubName: Full=Angiotensin II receptor, type 1, isoform CRA_b; SubName: Full=cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA;
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: AGTR1
Diseases sorted by gene-association score: renal tubular dysgenesis* (1146), hypertension, essential* (292), renal dysplasia* (200), cardiovascular disease risk factor )* (100), renal tubular dysgenesis, agtr1-related* (100), nephrosclerosis (21), hyperaldosteronism (17), iga glomerulonephritis (15), ureteral obstruction (14), diastolic heart failure (14), hypertensive heart disease (13), renal artery disease (12), silent myocardial infarction (11), malignant hypertension (10), mitral valve disease (10), nonarteritic anterior ischemic optic neuropathy (9), congestive heart failure (9), congenital hepatic fibrosis (9), vesicoureteral reflux (8), renal fibrosis (8), cerebrovascular disease (8), renovascular hypertension (7), anuria (7), posterior urethral valves (7), microvascular complications of diabetes 3 (7), portal hypertension (7), familial hypertension (7), familial hyperaldosteronism (7), kidney disease (6), fibromuscular dysplasia (6), aortic coarctation (6), meningococcal infection (6), marfan syndrome (6), conn's syndrome (6), oligohydramnios (5), myocardial stunning (5), coronary artery disease (5), in situ carcinoma (5), acute mountain sickness (5), ischemic optic neuropathy (5), renal hypertension (5), orthostatic intolerance (4), heart disease (4), myocardial infarction (4), end stage renal failure (3), diabetes mellitus, insulin-dependent (3), artery disease (3), atrial fibrillation (3), pre-eclampsia (3), chronic kidney failure (2), diabetes mellitus, noninsulin-dependent (2), microvascular complications of diabetes 5 (2), stroke, ischemic (2), preeclampsia/eclampsia 1 (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 30.18 RPKM in Adipose - Subcutaneous
Total median expression: 202.53 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -138.60356-0.389 Picture PostScript Text
3' UTR -189.10888-0.213 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR000190 - ATII_AT1_rcpt
IPR000248 - ATII_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx

SCOP Domains:
47954 - Cyclin-like
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q53YY0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004945 angiotensin type II receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0019229 regulation of vasoconstriction
GO:0038166 angiotensin-activated signaling pathway

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  D13814 - Homo sapiens mRNA for angiotensin II type 1b receptor, complete cds.
JD183543 - Sequence 164567 from Patent EP1572962.
AK291541 - Homo sapiens cDNA FLJ75705 complete cds, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA.
BC068494 - Homo sapiens angiotensin II receptor, type 1, mRNA (cDNA clone MGC:87211 IMAGE:30337806), complete cds.
BC022447 - Homo sapiens angiotensin II receptor, type 1, mRNA (cDNA clone MGC:25987 IMAGE:4799755), complete cds.
JD518159 - Sequence 499183 from Patent EP1572962.
JD263872 - Sequence 244896 from Patent EP1572962.
M87290 - Human angiotensin II type 1 receptor mRNA, complete cds.
JD439554 - Sequence 420578 from Patent EP1572962.
S77410 - Homo sapiens type 1 angiotensin II receptor mRNA, complete cds.
X65699 - H.sapiens mRNA for angiotensin II receptor.
JD215245 - Sequence 196269 from Patent EP1572962.
M93394 - Human angiotensin II type-1 receptor (AT1) mRNA, complete cds.
JD350633 - Sequence 331657 from Patent EP1572962.
AB463409 - Synthetic construct DNA, clone: pF1KB7156, Homo sapiens AGTR1 gene for angiotensin II receptor, type 1, without stop codon, in Flexi system.
DQ892388 - Synthetic construct clone IMAGE:100005018; FLH185855.01X; RZPDo839F10148D angiotensin II receptor, type 1 (AGTR1) gene, encodes complete protein.
DQ895601 - Synthetic construct Homo sapiens clone IMAGE:100010061; FLH185851.01L; RZPDo839F10147D angiotensin II receptor, type 1 (AGTR1) gene, encodes complete protein.
KJ896398 - Synthetic construct Homo sapiens clone ccsbBroadEn_05792 AGTR1 gene, encodes complete protein.
KJ896399 - Synthetic construct Homo sapiens clone ccsbBroadEn_05793 AGTR1 gene, encodes complete protein.
KR711421 - Synthetic construct Homo sapiens clone CCSBHm_00023494 AGTR1 (AGTR1) mRNA, encodes complete protein.
KR711422 - Synthetic construct Homo sapiens clone CCSBHm_00023495 AGTR1 (AGTR1) mRNA, encodes complete protein.
KR711423 - Synthetic construct Homo sapiens clone CCSBHm_00023496 AGTR1 (AGTR1) mRNA, encodes complete protein.
KR711424 - Synthetic construct Homo sapiens clone CCSBHm_00023497 AGTR1 (AGTR1) mRNA, encodes complete protein.
JD534485 - Sequence 515509 from Patent EP1572962.
JD385529 - Sequence 366553 from Patent EP1572962.
JD315814 - Sequence 296838 from Patent EP1572962.
JD174382 - Sequence 155406 from Patent EP1572962.
JD063568 - Sequence 44592 from Patent EP1572962.
JD061645 - Sequence 42669 from Patent EP1572962.
JD090713 - Sequence 71737 from Patent EP1572962.
JD508417 - Sequence 489441 from Patent EP1572962.
JD548536 - Sequence 529560 from Patent EP1572962.
JD410326 - Sequence 391350 from Patent EP1572962.
JD046423 - Sequence 27447 from Patent EP1572962.
JD273297 - Sequence 254321 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_ace2Pathway - Angiotensin-converting enzyme 2 regulates heart function
h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling

-  Other Names for This Gene
  Alternate Gene Symbols: AGTR1 , D3DNG9, ENST00000349243.1, ENST00000349243.2, ENST00000349243.3, ENST00000349243.4, ENST00000349243.5, ENST00000349243.6, ENST00000349243.7, hCG_2022206 , NM_031850, Q53YY0, Q53YY0_HUMAN, uc317xuo.1, uc317xuo.2
UCSC ID: ENST00000349243.8_8
RefSeq Accession: NM_000685.5
Protein: Q53YY0

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.