ID:ELYS_HUMAN DESCRIPTION: RecName: Full=Protein ELYS; AltName: Full=Embryonic large molecule derived from yolk sac; AltName: Full=Protein MEL-28; AltName: Full=Putative AT-hook-containing transcription factor 1; FUNCTION: Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. SUBUNIT: Associates with the Nup107-160 subcomplex of the NPC. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus matrix (By similarity). Chromosome, centromere, kinetochore. Nucleus, nucleoplasm. Nucleus, nuclear pore complex. Note=Localizes to the nuclear pore complex (NPC) throughout interphase. Localizes to the kinetochore from prophase, and this appears to require the Nup107- 160 subcomplex of the NPC. Localizes to the periphery of chromatin from late anaphase. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the ELYS family. SIMILARITY: Contains 1 A.T hook DNA-binding domain. SEQUENCE CAUTION: Sequence=AAN65622.1; Type=Frameshift; Positions=Several; Sequence=AAQ13621.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB78516.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WYP5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding
Biological Process: GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007049 cell cycle GO:0015031 protein transport GO:0032465 regulation of cytokinesis GO:0051028 mRNA transport GO:0051292 nuclear pore complex assembly GO:0051301 cell division
AY157619 - Homo sapiens ELYS transcription factor-like protein TMBS62 (TMBS62) mRNA, complete cds. AB059277 - Homo sapiens mRNA for transcription factor ELYS, complete cds. BC156054 - Synthetic construct Homo sapiens clone IMAGE:100062330, MGC:190464 AT hook containing transcription factor 1 (AHCTF1) mRNA, encodes complete protein. BC012307 - Homo sapiens AT hook containing transcription factor 1, mRNA (cDNA clone IMAGE:3867738), partial cds. AL832213 - Homo sapiens mRNA; cDNA DKFZp686P072 (from clone DKFZp686P072). BC047361 - Homo sapiens AT hook containing transcription factor 1, mRNA (cDNA clone IMAGE:5278498). AF173978 - Homo sapiens MSTP108 (MST108) mRNA, complete cds. JD051506 - Sequence 32530 from Patent EP1572962. AL080144 - Homo sapiens mRNA; cDNA DKFZp434N093 (from clone DKFZp434N093); partial cds. AL833491 - Homo sapiens mRNA; cDNA DKFZp686I2429 (from clone DKFZp686I2429). AK091364 - Homo sapiens cDNA FLJ34045 fis, clone FCBBF2007095, highly similar to AT-hook-containing transcription factor 1. AX746937 - Sequence 462 from Patent EP1308459. BC030564 - Homo sapiens AT hook containing transcription factor 1, mRNA (cDNA clone IMAGE:4446957). AK095398 - Homo sapiens cDNA FLJ38079 fis, clone CTONG2016056, highly similar to AT-hook-containing transcription factor 1. AK091510 - Homo sapiens cDNA FLJ34191 fis, clone FCBBF3017918. AX747030 - Sequence 555 from Patent EP1308459. AK122844 - Homo sapiens cDNA FLJ16456 fis, clone BRAWH3009013, highly similar to AT-hook-containing transcription factor 1. LF205488 - JP 2014500723-A/12991: Polycomb-Associated Non-Coding RNAs. LF321136 - JP 2014500723-A/128639: Polycomb-Associated Non-Coding RNAs. LF321137 - JP 2014500723-A/128640: Polycomb-Associated Non-Coding RNAs. MA441065 - JP 2018138019-A/12991: Polycomb-Associated Non-Coding RNAs. MA556713 - JP 2018138019-A/128639: Polycomb-Associated Non-Coding RNAs. MA556714 - JP 2018138019-A/128640: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8WYP5 (Reactome details) participates in the following event(s):
R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
