ID:FETUA_HUMAN DESCRIPTION: RecName: Full=Alpha-2-HS-glycoprotein; AltName: Full=Alpha-2-Z-globulin; AltName: Full=Ba-alpha-2-glycoprotein; AltName: Full=Fetuin-A; Contains: RecName: Full=Alpha-2-HS-glycoprotein chain A; Contains: RecName: Full=Alpha-2-HS-glycoprotein chain B; Flags: Precursor; FUNCTION: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. SUBUNIT: Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond. INTERACTION: P00519:ABL1; NbExp=1; IntAct=EBI-1223374, EBI-375543; O88736:Hsd17b7 (xeno); NbExp=1; IntAct=EBI-1223374, EBI-2552537; SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins. PTM: Phosphorylation sites are present in the extracellular medium. PTM: O- and N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan at Asn-156: Hex5HexNAc4; N-glycan heterogeneity at Asn-176: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor). POLYMORPHISM: There are two common alleles, AHSG*1 and AHSG*2. AHSG*1 has Thr-248/Thr-256; AHSG*2 has Met-248/Ser-256. SIMILARITY: Belongs to the fetuin family. SIMILARITY: Contains 2 cystatin fetuin-A-type domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P02765
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001501 skeletal system development GO:0001503 ossification GO:0002576 platelet degranulation GO:0006907 pinocytosis GO:0006953 acute-phase response GO:0010951 negative regulation of endopeptidase activity GO:0030500 regulation of bone mineralization GO:0030502 negative regulation of bone mineralization GO:0042326 negative regulation of phosphorylation GO:0043312 neutrophil degranulation GO:0043687 post-translational protein modification GO:0044267 cellular protein metabolic process GO:0046627 negative regulation of insulin receptor signaling pathway GO:0050727 regulation of inflammatory response GO:0050766 positive regulation of phagocytosis GO:0070168 negative regulation of biomineral tissue development
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
