ID:AIP_HUMAN DESCRIPTION: RecName: Full=AH receptor-interacting protein; Short=AIP; AltName: Full=Aryl-hydrocarbon receptor-interacting protein; AltName: Full=HBV X-associated protein 2; Short=XAP-2; AltName: Full=Immunophilin homolog ARA9; FUNCTION: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. FUNCTION: Cellular negative regulator of the hepatitis B virus (HBV) X protein. SUBUNIT: Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex. INTERACTION: Q92985:IRF7; NbExp=2; IntAct=EBI-704197, EBI-968267; O00408:PDE2A; NbExp=6; IntAct=EBI-704197, EBI-1785967; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver. DISEASE: Defects in AIP are a cause of growth hormone-secreting pituitary adenoma (GHSPA) [MIM:102200]; also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma. DISEASE: Defects in AIP are a cause of ACTH-secreting pituitary adenoma (ASPA) [MIM:219090]; also known as pituitary Cushing disease. A pituary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. DISEASE: Defects in AIP are a cause of prolactin-secreting pituitary adenoma (PSPA) [MIM:600634]; also known as prolactinoma. Prolactin-secreting pituitary adenoma is the most common type of hormonally active pituitary adenoma. SIMILARITY: Contains 1 PPIase FKBP-type domain. SIMILARITY: Contains 2 TPR repeats. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/AIP";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00170
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003712 transcription cofactor activity GO:0003713 transcription coactivator activity GO:0004871 signal transducer activity GO:0005515 protein binding GO:0008134 transcription factor binding GO:0017162 aryl hydrocarbon receptor binding GO:0036004 GAF domain binding GO:0051082 unfolded protein binding
Biological Process: GO:0006626 protein targeting to mitochondrion GO:0006805 xenobiotic metabolic process GO:0010738 regulation of protein kinase A signaling GO:0022417 protein maturation by protein folding GO:0035722 interleukin-12-mediated signaling pathway GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
