Human Gene AK3 (ENST00000381809.8_7) from GENCODE V47lift37
  Description: adenylate kinase 3, transcript variant 1 (from RefSeq NM_016282.4)
Gencode Transcript: ENST00000381809.8_7
Gencode Gene: ENSG00000147853.17_10
Transcript (Including UTRs)
   Position: hg19 chr9:4,709,556-4,741,202 Size: 31,647 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr9:4,712,976-4,741,087 Size: 28,112 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:4,709,556-4,741,202)mRNA (may differ from genome)Protein (227 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KAD3_HUMAN
DESCRIPTION: RecName: Full=GTP:AMP phosphotransferase, mitochondrial; EC=2.7.4.10; AltName: Full=Adenylate kinase 3; Short=AK 3; AltName: Full=Adenylate kinase 3 alpha-like 1;
CATALYTIC ACTIVITY: NTP + AMP = NDP + ADP.
SUBUNIT: Monomer (By similarity).
SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
SIMILARITY: Belongs to the adenylate kinase family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 48.25 RPKM in Muscle - Skeletal
Total median expression: 1444.11 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -60.00115-0.522 Picture PostScript Text
3' UTR -1001.603420-0.293 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006259 - Adenyl_kin_sub
IPR000850 - Adenylate_kin
IPR007862 - Adenylate_kinase_lid-dom

Pfam Domains:
PF00406 - Adenylate kinase
PF05191 - Adenylate kinase, active site lid
PF13207 - AAA domain
PF13238 - AAA domain

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases
57774 - Microbial and mitochondrial ADK, insert "zinc finger" domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1ZD8 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9UIJ7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016776 phosphotransferase activity, phosphate group as acceptor
GO:0019205 nucleobase-containing compound kinase activity
GO:0046899 nucleoside triphosphate adenylate kinase activity
GO:0004017 adenylate kinase activity

Biological Process:
GO:0006139 nucleobase-containing compound metabolic process
GO:0007596 blood coagulation
GO:0016310 phosphorylation
GO:0046033 AMP metabolic process
GO:0046039 GTP metabolic process
GO:0046041 ITP metabolic process
GO:0046051 UTP metabolic process

Cellular Component:
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix


-  Descriptions from all associated GenBank mRNAs
  KJ893758 - Synthetic construct Homo sapiens clone ccsbBroadEn_03152 AK3 gene, encodes complete protein.
KJ905465 - Synthetic construct Homo sapiens clone ccsbBroadEn_15057 AK3 gene, encodes complete protein.
BC128429 - Homo sapiens cDNA clone IMAGE:40118648.
AF100785 - Homo sapiens GTP:AMP phosphotransferase mRNA, complete cds; nuclear gene encoding mitochondrial product.
AK001553 - Homo sapiens cDNA FLJ10691 fis, clone NT2RP3000359, highly similar to GTP:AMP PHOSPHOTRANSFERASE MITOCHONDRIAL (EC 2.7.4.10).
AK027534 - Homo sapiens cDNA FLJ14628 fis, clone NT2RP2000329, highly similar to GTP:AMP PHOSPHOTRANSFERASE MITOCHONDRIAL (EC 2.7.4.10).
BC013771 - Homo sapiens adenylate kinase 3, mRNA (cDNA clone MGC:21124 IMAGE:4385034), complete cds.
AF183419 - Homo sapiens GTP:AMP phosphotransferase mRNA, complete cds; nuclear gene for mitochondrial product.
AK124824 - Homo sapiens cDNA FLJ42834 fis, clone BRCAN2019002, highly similar to GTP:AMP phosphotransferase mitochondrial (EC 2.7.4.10).
AK098205 - Homo sapiens cDNA FLJ40886 fis, clone UTERU2000663, highly similar to GTP:AMP phosphotransferase mitochondrial (EC 2.7.4.10).
AK001951 - Homo sapiens cDNA FLJ11089 fis, clone PLACE1005305, highly similar to GTP:AMP PHOSPHOTRANSFERASE MITOCHONDRIAL (EC 2.7.4.10).
AK298200 - Homo sapiens cDNA FLJ58032 complete cds, highly similar to GTP:AMP phosphotransferase mitochondrial (EC 2.7.4.10).
AF086913 - Homo sapiens GTP:ATP phosphotransferase mRNA, complete cds.
AB021870 - Homo sapiens hAK3alpha mRNA for adenylate kinase 3 alpha, complete cds.
DQ891660 - Synthetic construct clone IMAGE:100004290; FLH179055.01X; RZPDo839C04130D adenylate kinase 3 (AK3) gene, encodes complete protein.
DQ894847 - Synthetic construct Homo sapiens clone IMAGE:100009307; FLH179051.01L; RZPDo839C04129D adenylate kinase 3 (AK3) gene, encodes complete protein.
BX640794 - Homo sapiens mRNA; cDNA DKFZp686M14193 (from clone DKFZp686M14193).
JD311731 - Sequence 292755 from Patent EP1572962.
JD456810 - Sequence 437834 from Patent EP1572962.
JD293118 - Sequence 274142 from Patent EP1572962.
JD293119 - Sequence 274143 from Patent EP1572962.
JD234087 - Sequence 215111 from Patent EP1572962.
JD234086 - Sequence 215110 from Patent EP1572962.
JD090905 - Sequence 71929 from Patent EP1572962.
JD550254 - Sequence 531278 from Patent EP1572962.
JD550253 - Sequence 531277 from Patent EP1572962.
JD428254 - Sequence 409278 from Patent EP1572962.
JD528144 - Sequence 509168 from Patent EP1572962.
JD064043 - Sequence 45067 from Patent EP1572962.
JD441177 - Sequence 422201 from Patent EP1572962.
JD441176 - Sequence 422200 from Patent EP1572962.
JD556160 - Sequence 537184 from Patent EP1572962.
JD244449 - Sequence 225473 from Patent EP1572962.
JD301974 - Sequence 282998 from Patent EP1572962.
JD502049 - Sequence 483073 from Patent EP1572962.
JD305923 - Sequence 286947 from Patent EP1572962.
JD267046 - Sequence 248070 from Patent EP1572962.
JD194304 - Sequence 175328 from Patent EP1572962.
JD075210 - Sequence 56234 from Patent EP1572962.
JD348977 - Sequence 330001 from Patent EP1572962.
JD315151 - Sequence 296175 from Patent EP1572962.
JD309396 - Sequence 290420 from Patent EP1572962.
JD102315 - Sequence 83339 from Patent EP1572962.
JD296675 - Sequence 277699 from Patent EP1572962.
JD565473 - Sequence 546497 from Patent EP1572962.
JD206589 - Sequence 187613 from Patent EP1572962.
JD299711 - Sequence 280735 from Patent EP1572962.
JD239823 - Sequence 220847 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-7219 - adenosine ribonucleotides de novo biosynthesis
PWY-841 - purine nucleotides de novo biosynthesis
PWY66-409 - superpathway of purine nucleotide salvage

Reactome (by CSHL, EBI, and GO)

Protein Q9UIJ7 (Reactome details) participates in the following event(s):

R-HSA-1008248 Adenylate Kinase 3 is a GTP-AMP phosphotransferase
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-109582 Hemostasis

-  Other Names for This Gene
  Alternate Gene Symbols: AK3 , AK3L1, AK6, AKL3L, B4DP58, D3DRI1, E7ET30, ENST00000381809.1, ENST00000381809.2, ENST00000381809.3, ENST00000381809.4, ENST00000381809.5, ENST00000381809.6, ENST00000381809.7, KAD3_HUMAN, NM_016282, Q5VYW6, Q9H576, Q9HC01, Q9NPB4, Q9UIJ7, uc318qmf.1, uc318qmf.2
UCSC ID: ENST00000381809.8_7
RefSeq Accession: NM_016282.4
Protein: Q9UIJ7 (aka KAD3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.