ID:AKP13_HUMAN DESCRIPTION: RecName: Full=A-kinase anchor protein 13; Short=AKAP-13; AltName: Full=AKAP-Lbc; AltName: Full=Breast cancer nuclear receptor-binding auxiliary protein; AltName: Full=Guanine nucleotide exchange factor Lbc; AltName: Full=Human thyroid-anchoring protein 31; AltName: Full=Lymphoid blast crisis oncogene; Short=LBC oncogene; AltName: Full=Non-oncogenic Rho GTPase-specific GTP exchange factor; AltName: Full=Protein kinase A-anchoring protein 13; Short=PRKA13; AltName: Full=p47; FUNCTION: Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element- specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. SUBUNIT: Binds cAMP-dependent protein kinase (PKA) and to the RII- alpha regulatory subunit of PKA. Interacts with ESR1, ESR2, THRA, PPARA, RHOA and NME2. INTERACTION: P03372:ESR1; NbExp=3; IntAct=EBI-1373806, EBI-78473; P21980:TGM2; NbExp=4; IntAct=EBI-1373806, EBI-727668; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Membrane. TISSUE SPECIFICITY: Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen- responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb transcript in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Transcripts of between 6-9 kb are also expressed in myeloid and lymphoid lineages, a variety of epithelial tissues, and in skeletal muscle. DOMAIN: Both the DH and PH domains are required for transforming activity. SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 phorbol-ester/DAG-type zinc finger. SEQUENCE CAUTION: Sequence=AAC50065.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAC50065.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAD21311.1; Type=Frameshift; Positions=2614, 2647; Sequence=AAD40799.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAD40799.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAL40923.1; Type=Frameshift; Positions=2614, 2647;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q12802
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004691 cAMP-dependent protein kinase activity GO:0004871 signal transducer activity GO:0005078 MAP-kinase scaffold activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0005515 protein binding GO:0017048 Rho GTPase binding GO:0032947 protein complex scaffold GO:0046872 metal ion binding GO:0051018 protein kinase A binding
Biological Process: GO:0006468 protein phosphorylation GO:0007186 G-protein coupled receptor signaling pathway GO:0007507 heart development GO:0010611 regulation of cardiac muscle hypertrophy GO:0035023 regulation of Rho protein signal transduction GO:0035025 positive regulation of Rho protein signal transduction GO:0035556 intracellular signal transduction GO:0043065 positive regulation of apoptotic process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043406 positive regulation of MAP kinase activity GO:0045859 regulation of protein kinase activity GO:0051056 regulation of small GTPase mediated signal transduction GO:0051168 nuclear export GO:0055007 cardiac muscle cell differentiation GO:0060297 regulation of sarcomere organization GO:0060348 bone development GO:0071875 adrenergic receptor signaling pathway GO:0086023 adrenergic receptor signaling pathway involved in heart process GO:1900169 regulation of glucocorticoid mediated signaling pathway
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
