ID:AKAP4_HUMAN DESCRIPTION: RecName: Full=A-kinase anchor protein 4; Short=AKAP-4; AltName: Full=A-kinase anchor protein 82 kDa; Short=AKAP 82; Short=hAKAP82; AltName: Full=Major sperm fibrous sheath protein; Short=HI; AltName: Full=Protein kinase A-anchoring protein 4; Short=PRKA4; Flags: Precursor; FUNCTION: Major structural component of sperm fibrous sheath. Plays a role in sperm motility. SUBUNIT: Interacts with PRKAR1A and PRKAR2A (By similarity). SUBCELLULAR LOCATION: Cell projection, cilium, flagellum. Note=Localizes to the principle piece of the sperm flagellum. TISSUE SPECIFICITY: Testis specific; only expressed in round spermatids. DEVELOPMENTAL STAGE: Post-meiotic phase of spermatogenesis. DOMAIN: RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer (By similarity). SIMILARITY: Belongs to the AKAP110 family. SEQUENCE CAUTION: Sequence=CAA75494.1; Type=Frameshift; Positions=Several;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5JQC9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0051018 protein kinase A binding
Biological Process: GO:0007165 signal transduction GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007338 single fertilization GO:0008104 protein localization GO:0010738 regulation of protein kinase A signaling GO:0030030 cell projection organization GO:0030317 flagellated sperm motility GO:0044458 motile cilium assembly GO:0045184 establishment of protein localization
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
